Chemopreventive effect of cooked chickpea on colon carcinogenesis evolution in AOM/DSS-Induced Balb/c Mice

Chickpeas are one of the most widely consumed legumes worldwide and they might prevent diseases such as cancer. Therefore, this study evaluates the chemopreventive effect of chickpea (Cicer arietinum L.) on the evolution of colon carcinogenesis induced with azoxymethane (AOM) and dextran sodium sulfate (DSS) in a mice model at 1, 7, and 14 weeks after induction. Accordingly, the expression of biomarkers—such as argyrophilic nucleolar organizing regions (AgNOR), cell proliferation nuclear antigen (PCNA), β-catenin, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2)—was assessed in the colon of BALB/c mice fed diets supplemented with 10 and 20% cooked chickpea (CC). The results showed that a 20% CC diet significantly reduced tumors and biomarkers of proliferation and inflammation in AOM/DSS-induced colon cancer mice. Moreover, body weight loss decreased and the disease activity index (DAI) was lower than the positive control. Lastly, tumor reduction was more evident at week 7 in the groups fed a 20% CC diet. In conclusion, both diets (10% and 20% CC) exert a chemopreventive effect.

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Bibliographic Details
Main Authors: Cid Gallegos, María Stephanie autora, Jiménez Martínez, Cristian Doctora autor 22504, Sánchez Chino, Xariss Miryam Doctora autora 14483, Madrigal Bujaidar, Eduardo autor, Vásquez Garzón, Verónica R. autora, Baltiérrez Hoyos, Rafael autor, Álvarez González, Isela autora
Format: Texto biblioteca
Language:eng
Subjects:Carcinogénesis de cólon, Garbanzos, Quimioprevención, Azoximetano, Dextran sulfato de sodio, Medicina preventiva, Artfrosur,
Online Access:https://doi.org/10.3390/plants12122317
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