Leukoencephalomalacia in equine on the West coast of Uruguay
Three outbreaks of equine leukoencephalomalacia diagnosed by the Northwest Regional Laboratory DILAVE "Miguel C. Rubino" are described. All of them occurred in summer and early spring associated with ingestion of corn. In the first two outbreaks only one equine was affected respectively, while in the third one, 7 of 15 animals showed symptoms and died (morbidity and mortality 47%); being the lethality 100% in the three situations. The main gross lesions were observed in the central nervous system with multifocal yellow areas of softening, cavitation and hemorrhage on the white matter, mainly in the thalamus, hippocampus, caudate nucleus and brainstem areas. At the histopathology areas of malacia and vacuolation of white matter, surrounded by edema and hemorrhage with degenerative changes in the vascular endothelium were found. One of the affected animals had degenerative lesions in the liver, consistent with periacinar hemorrhagic necrosis and vacuolation ofmidzonal hepatocytes. In the third outbreak, it was detennined the concentration of fumonisins in the com through a competitive ELISA, with a result of 6,91 J1g/g.
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Sociedad de Medicina Veterinaria del Uruguay (SMVU)
2013
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rev-smvu-uy-article-2202019-10-30T18:50:38Z Leukoencephalomalacia in equine on the West coast of Uruguay Leucoencefalomalacia en equinos en el litoral oeste de Uruguay Rivero, R. Collazo, S. Ugarte, E. Nan, F. Mazzolini, Y. Matto, C. Leucoencefalomalacia equina Micotoxinas Fusarium Equine Leukoencephalomalacia Micotoxins Fusarium Three outbreaks of equine leukoencephalomalacia diagnosed by the Northwest Regional Laboratory DILAVE "Miguel C. Rubino" are described. All of them occurred in summer and early spring associated with ingestion of corn. In the first two outbreaks only one equine was affected respectively, while in the third one, 7 of 15 animals showed symptoms and died (morbidity and mortality 47%); being the lethality 100% in the three situations. The main gross lesions were observed in the central nervous system with multifocal yellow areas of softening, cavitation and hemorrhage on the white matter, mainly in the thalamus, hippocampus, caudate nucleus and brainstem areas. At the histopathology areas of malacia and vacuolation of white matter, surrounded by edema and hemorrhage with degenerative changes in the vascular endothelium were found. One of the affected animals had degenerative lesions in the liver, consistent with periacinar hemorrhagic necrosis and vacuolation ofmidzonal hepatocytes. In the third outbreak, it was detennined the concentration of fumonisins in the com through a competitive ELISA, with a result of 6,91 J1g/g. Se describen tres focos de leucoencefalomalacia en equinos diagnosticados por el Laboratorio Regional Noroeste DILAVE "Miguel C. Rubino". Los mismos se presentaron en verano y primavera temprana, asociados al consumo de maíz. En los dos primeros focos se afectó un solo equino, mientras que en el tercero de 15 animales enfermaron y murieron 7 (morbilidad y mortalidad 47%), siendo en los tres brotes la letalidad del 100%. Las lesiones macroscópicas más destacadas se observaron en el sistema nervioso central con áreas amarillas multifocales de reblandecimiento, cavitación y hemorragias, afectando la sustancia blanca principalmente a nivel del tálamo, hipocampo, núcleo caudado y áreas del tronco encefálico. En la histopatología del sistema nervioso central se encontraron áreas de malacia y vacuolización de la sustancia blanca, rodeadas por edema y hemorragias con cambios degenerativos en el endotelio vascular. En el hígado de uno de los animales examinados, había lesiones degenerativas, consistentes con necrosis periacinar hemorrágica y vacuolización de los hepatocitos mediozonales. En el tercer foco como complemento al diagnóstico, se realizó la determinación de la presencia de fumonisinas en el maíz a través de la técnica de ELISA competitivo, con un resultado de 6,91 Ilg/g. Sociedad de Medicina Veterinaria del Uruguay (SMVU) 2013-03-01 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed article. Artículo evaluado por pares. Artigo revisado por pares. application/pdf https://www.revistasmvu.com.uy/index.php/smvu/article/view/220 Veterinaria (Montevideo); Vol. 49 No. 189 (2013): March; 39-45 Veterinaria (Montevideo); Vol. 49 Núm. 189 (2013): Marzo; 39-45 Veterinaria (Montevideo); v. 49 n. 189 (2013): Março; 39-45 1688-4809 0376-4362 spa https://www.revistasmvu.com.uy/index.php/smvu/article/view/220/145 Derechos de autor 2013 Sociedad de Medicina Veterinaria del Uruguay |
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Biblioteca de la Facultad de Veterinaria de la UDELAR de UY |
| language |
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Digital |
| author |
Rivero, R. Collazo, S. Ugarte, E. Nan, F. Mazzolini, Y. Matto, C. |
| spellingShingle |
Rivero, R. Collazo, S. Ugarte, E. Nan, F. Mazzolini, Y. Matto, C. Leukoencephalomalacia in equine on the West coast of Uruguay |
| author_facet |
Rivero, R. Collazo, S. Ugarte, E. Nan, F. Mazzolini, Y. Matto, C. |
| author_sort |
Rivero, R. |
| title |
Leukoencephalomalacia in equine on the West coast of Uruguay |
| title_short |
Leukoencephalomalacia in equine on the West coast of Uruguay |
| title_full |
Leukoencephalomalacia in equine on the West coast of Uruguay |
| title_fullStr |
Leukoencephalomalacia in equine on the West coast of Uruguay |
| title_full_unstemmed |
Leukoencephalomalacia in equine on the West coast of Uruguay |
| title_sort |
leukoencephalomalacia in equine on the west coast of uruguay |
| description |
Three outbreaks of equine leukoencephalomalacia diagnosed by the Northwest Regional Laboratory DILAVE "Miguel C. Rubino" are described. All of them occurred in summer and early spring associated with ingestion of corn. In the first two outbreaks only one equine was affected respectively, while in the third one, 7 of 15 animals showed symptoms and died (morbidity and mortality 47%); being the lethality 100% in the three situations. The main gross lesions were observed in the central nervous system with multifocal yellow areas of softening, cavitation and hemorrhage on the white matter, mainly in the thalamus, hippocampus, caudate nucleus and brainstem areas. At the histopathology areas of malacia and vacuolation of white matter, surrounded by edema and hemorrhage with degenerative changes in the vascular endothelium were found. One of the affected animals had degenerative lesions in the liver, consistent with periacinar hemorrhagic necrosis and vacuolation ofmidzonal hepatocytes. In the third outbreak, it was detennined the concentration of fumonisins in the com through a competitive ELISA, with a result of 6,91 J1g/g. |
| publisher |
Sociedad de Medicina Veterinaria del Uruguay (SMVU) |
| publishDate |
2013 |
| url |
https://www.revistasmvu.com.uy/index.php/smvu/article/view/220 |
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