Histopathological diagnostic approach in Saguinus leucopus with cronic chagasic cardiomyopathy in rehabilitation and re-introduction programs

Histopathological diagnostic approach in Saguinus leucopus with cronic chagasic cardiomyopathy in rehabilitation and re-introduction programs

Saguinus leucopus is an endemic primate in Colombia considered vulnerable, furthermore with the most restricted geographical distribution between Saguinus spp.. It is known as a natural reservoir of Trypanosoma cruzi since it shares geographic distribution with the vectors Rhodnious prolixus and Triatoma dimidiate . However, this primate does not develop chronic chagasic cardiomyopathy in a natural way. Nevertheless, a histopathological chronic chagasic cardiomyopathy approach diagnosis should be established in S. leucopus in rehabilitation centers and for reintroduction programs, when they have been diagnosed to be infected by Trypanosoma spp. with haemograms. Simultaneously, when death occurs in the same colony and necropsy shows cardiomegaly and splenomegaly. In these cases, heart histopathology could display myocarditis with lymphomonocitary infiltration, limited to myocardium, with negative CD 19 but positive CD3 and CD68. These findings, together with the observation of cardiomyocytes containing rod-forms of 2 microns in diameter, enclosed into a "pod" with homogeneous eosinophilic thickness are characteristic of "pseudocysts", the typical amastigotes in "Chagasic cardiomyopathy" caused by T. cruzi .

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Main Authors: Acero Mondragón, Edward Javier, Maldonado Arango, María Inés, Angulo Calderón, Nohora Mercedes
Format: Digital revista
Language:spa
Published: Universidad de Ciencias Aplicadas y Ambientales U.D.C.A 2012
Online Access:https://revistas.udca.edu.co/index.php/ruadc/article/view/801
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id rev-ruadc-co-article-801
record_format ojs
institution UDCA CO
collection OJS
country Colombia
countrycode CO
component Revista
access En linea
databasecode rev-ruadc-co
tag revista
region America del Sur
libraryname Biblioteca de la UDCA de Colombia
language spa
format Digital
author Acero Mondragón, Edward Javier
Maldonado Arango, María Inés
Angulo Calderón, Nohora Mercedes
spellingShingle Acero Mondragón, Edward Javier
Maldonado Arango, María Inés
Angulo Calderón, Nohora Mercedes
Histopathological diagnostic approach in Saguinus leucopus with cronic chagasic cardiomyopathy in rehabilitation and re-introduction programs
author_facet Acero Mondragón, Edward Javier
Maldonado Arango, María Inés
Angulo Calderón, Nohora Mercedes
author_sort Acero Mondragón, Edward Javier
title Histopathological diagnostic approach in Saguinus leucopus with cronic chagasic cardiomyopathy in rehabilitation and re-introduction programs
title_short Histopathological diagnostic approach in Saguinus leucopus with cronic chagasic cardiomyopathy in rehabilitation and re-introduction programs
title_full Histopathological diagnostic approach in Saguinus leucopus with cronic chagasic cardiomyopathy in rehabilitation and re-introduction programs
title_fullStr Histopathological diagnostic approach in Saguinus leucopus with cronic chagasic cardiomyopathy in rehabilitation and re-introduction programs
title_full_unstemmed Histopathological diagnostic approach in Saguinus leucopus with cronic chagasic cardiomyopathy in rehabilitation and re-introduction programs
title_sort histopathological diagnostic approach in saguinus leucopus with cronic chagasic cardiomyopathy in rehabilitation and re-introduction programs
description Saguinus leucopus is an endemic primate in Colombia considered vulnerable, furthermore with the most restricted geographical distribution between Saguinus spp.. It is known as a natural reservoir of Trypanosoma cruzi since it shares geographic distribution with the vectors Rhodnious prolixus and Triatoma dimidiate . However, this primate does not develop chronic chagasic cardiomyopathy in a natural way. Nevertheless, a histopathological chronic chagasic cardiomyopathy approach diagnosis should be established in S. leucopus in rehabilitation centers and for reintroduction programs, when they have been diagnosed to be infected by Trypanosoma spp. with haemograms. Simultaneously, when death occurs in the same colony and necropsy shows cardiomegaly and splenomegaly. In these cases, heart histopathology could display myocarditis with lymphomonocitary infiltration, limited to myocardium, with negative CD 19 but positive CD3 and CD68. These findings, together with the observation of cardiomyocytes containing rod-forms of 2 microns in diameter, enclosed into a "pod" with homogeneous eosinophilic thickness are characteristic of "pseudocysts", the typical amastigotes in "Chagasic cardiomyopathy" caused by T. cruzi .
publisher Universidad de Ciencias Aplicadas y Ambientales U.D.C.A
publishDate 2012
url https://revistas.udca.edu.co/index.php/ruadc/article/view/801
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spelling rev-ruadc-co-article-8012021-07-13T07:56:06Z Histopathological diagnostic approach in Saguinus leucopus with cronic chagasic cardiomyopathy in rehabilitation and re-introduction programs Aproximación diagnóstica histopatológica a la cardiomiopatía chagásica crónica en Saguinus leucopus dentro de programas de rehabilitación y reintroducción Acero Mondragón, Edward Javier Maldonado Arango, María Inés Angulo Calderón, Nohora Mercedes S. leucopus T. cruzi Cardiomiopatia chagásica S. leucopus T. cruzi Chagasic cardiomyopathy Saguinus leucopus is an endemic primate in Colombia considered vulnerable, furthermore with the most restricted geographical distribution between Saguinus spp.. It is known as a natural reservoir of Trypanosoma cruzi since it shares geographic distribution with the vectors Rhodnious prolixus and Triatoma dimidiate . However, this primate does not develop chronic chagasic cardiomyopathy in a natural way. Nevertheless, a histopathological chronic chagasic cardiomyopathy approach diagnosis should be established in S. leucopus in rehabilitation centers and for reintroduction programs, when they have been diagnosed to be infected by Trypanosoma spp. with haemograms. Simultaneously, when death occurs in the same colony and necropsy shows cardiomegaly and splenomegaly. In these cases, heart histopathology could display myocarditis with lymphomonocitary infiltration, limited to myocardium, with negative CD 19 but positive CD3 and CD68. These findings, together with the observation of cardiomyocytes containing rod-forms of 2 microns in diameter, enclosed into a "pod" with homogeneous eosinophilic thickness are characteristic of "pseudocysts", the typical amastigotes in "Chagasic cardiomyopathy" caused by T. cruzi . Saguinus leucopus es un primate endémico de Colombia considerado vulnerable, además, con la distribución geográfica más restringida entre Saguinus sp. Así mismo, es reconocido como reservorio natural de Trypanosoma cruzi, por compartir la distribución geográfica con vectores, como Rhodnious prolixus y Triatoma dimidiata ; sin embargo, el primate no presenta cardiomiopatía chagásica crónica de manera natural. Aproximaciones histopatológicas para diagnosticar cardiomiopatía chagásica crónica en S. leucopus, se deben establecer cuando en programas de rehabilitación y de reintroducción se hallen en los cuadros hemáticos Trypanosomas spp., paralelamente con decesos en las mismas colonias y que en las necropsias se demuestre cardiomegalias y esplenomegalias. Allí, la histopatología en corazón puede demostrar miocarditis, circunscrita al miocardio con infiltrado linfomonocitario inmunifenotipificado CD 19 negativo, pero CD3 y CD68 positivo, hallazgos que, junto a los cardiomiocitos conteniendo formas bastoniformes de 2 micras de diámetro, encerradas en una "vaina" eosinófila de grosor homogéneo, son característicos de "pseudoquistes" amastigóticos miocárdicos de cardiomiopatia chagásica, propios de los causados por la especie T. cruzi . Universidad de Ciencias Aplicadas y Ambientales U.D.C.A 2012-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/html https://revistas.udca.edu.co/index.php/ruadc/article/view/801 10.31910/rudca.v15.n1.2012.801 Revista U.D.C.A Actualidad & Divulgación Científica; Vol. 15 No. 1 (2012): Revista U.D.C.A Actualidad & Divulgación Científica. Enero-Junio; 43-48 Revista U.D.C.A Actualidad & Divulgación Científica; Vol. 15 Núm. 1 (2012): Revista U.D.C.A Actualidad & Divulgación Científica. Enero-Junio; 43-48 Revista U.D.C.A Actualidad & Divulgación Científica; v. 15 n. 1 (2012): Revista U.D.C.A Actualidad & Divulgación Científica. Enero-Junio; 43-48 2619-2551 0123-4226 10.31910/rudca.v15.n1.2012 spa https://revistas.udca.edu.co/index.php/ruadc/article/view/801/889 https://revistas.udca.edu.co/index.php/ruadc/article/view/801/890 /*ref*/ALMEIDA, E.A.; NAVARRO, M.R.; GUARIENTO, M.E.; CARVALHAL, S.S. 1992. Infecção experimental de macacos Cebus apella . pelo Trypanosoma cruzi . Avaliação clínica, eletrocardiográfica. Rev. Soc. Bras. Med. Trop. 25:7-12. /*ref*/ARBOLEDA, F.; QUINTANA, H. 2007. Histopatología de la enfermedad de Chagas. En: Rosas, F.; Vanegas, D.; Cabrales, M. eds. Enfermedad de Chagas. 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