Flourensia fiebrigii (Asterales: Asteraceae), source of antipathogenic metabolites
Verni, Cecilia; Alva, Mariana; Muruaga, Nora; Borkosky, Susana; Car tagena, Elena; Bardón, Alicia. 2011. “Flourensia fiebrigii (Asterales: Asteraceae), source of antipathogenic metabolites”. Lilloa 48 (1). This paper deals with the spectroscopic study of extracts from the shrub Flourensia fiebrigii and its activity against mature biofilm of two pathogenic bacteria. We employed an international collection of Staphylococcus aureus strain and a methicillin-resistant S. aureus strain. In order to propose anti-pathogenic metabolites of low toxicity to freshwater species, we determined the activity of the extracts against the snail Biomphalaria peregrina. The UV, FT-IR, 1H-NMR and 13C spectroscopic studies of the extracts from the aerial parts of F. fiebrigii revealed the presence of prenylated flavonoids. The dewaxed CHCl3 extract showed the highest biofilm disrupting activity at 50 µg/mL against the methicillin-resistant strain (65%), while the crude CHCl3 extract showed a 60% of reduction at 100 µg/mL. The active extract doses against the pathogenic S. aureus strains resulted not toxic to B. peregrina.
| Main Authors: | , , , , , |
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| Format: | Digital revista |
| Language: | spa |
| Published: |
Fundación Miguel Lillo
2011
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| Online Access: | http://www.lillo.org.ar/journals/index.php/lilloa/article/view/427 |
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