Aqueous extract of Pseudoelephantopus spicatus regulates blood glucose levels.

Currently, the field of phytopharmacology has demonstrated the antidiabetic potential of several traditional plants, among which is the Pseudoelephantopus spicatus, whose studies demonstrating its hypoglycemic effect are little known. For this reason in the present study its glycemic regulating effect was evaluated in a rat model. The experiments were carried out as a pilot test and validated in the kinetics of 0, 1, 2, 6, and 24 hours by means of five experimental groups (control, diabetics induced with alloxan, diabetics treated with metformin, and diabetics treated with Pseudoelephantopus spicatus extract with doses of 250 and 500 mg/kg). The treatments were applied for 1, 5, and 21 days. The results show that alloxan at 120 mg/kg induced Diabetes mellitus in 100% of the rats. The extract at 250 and 500 mg/kg achieved a significant reduction in blood glucose levels compared to diabetic rats, without showing significant differences between doses. The reduction of blood glucose levels caused by metformin at 500 mg/kg and the different doses of the extract did not show significant differences. According to the study findings, Pseudoelephantopus spicatus extract induces a hypoglycemic effect in rats.