Marine sponge: a sustainable biotechnological production?
Cancer is a disease with extensive worldwide incidence. Most tumors become invasive and metastatic over time; and additionally, the development of drug resistance of the cells due to the multiple forms of treatment is used intensively. Therefore, in recent decades, search for new bioactive substances with potential for development of new anticancer drugs has been stimulated. This pursuit has revealed that marine organisms, mainly sponges, offer a wide range of compounds with dierent activities, including anti-proliferative potential, useful in the development of antitumor drugs. In sustainable pharmaceutical production is required to produce large amount of biomass and avoid overexploitation of the species used. Thereby, strategies for in vitro production of interest metabolites are required. In this review, the major attempts of biotechnological production used in drug development from marine sponges and genetic, molecular and cell cycle found in the scientic literature are shown.
| Main Authors: | , , , |
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| Format: | Digital revista |
| Language: | spa |
| Published: |
Universidad Nacional de Colombia - Sede Medellín - Facultad de Ciencias
2014
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| Online Access: | https://revistas.unal.edu.co/index.php/rfc/article/view/50740 |
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