Gαi proteins are indispensable for hearing
Abstract: From invertebrates to mammals, Gαi proteins act together with their common binding partner Gpsm2 to govern cell polarization and planar organization in virtually any polarized cell. Recently, we demonstrated that Gαi3-deficiency in pre-hearing murine cochleae pointed to a role of Gαi3 for asymmetric migration of the kinocilium as well as the orientation and shape of the stereociliary ("hair") bundle, a requirement for the progression of mature hearing. We found that the lack of Gαi3 impairs stereociliary elongation and hair bundle shape in high-frequency cochlear regions, linked to elevated hearing thresholds for high-frequency sound. How these morphological defects translate into hearing phenotypes is not clear.
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Format: | Artículo biblioteca |
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2018
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Subjects: | GENES, AUDICION, PROTEINAS, SORDERA, PERDIDA AUDITIVA, MODIFICIACION GENETICA, |
Online Access: | https://repositorio.uca.edu.ar/handle/123456789/8692 |
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oai:ucacris:123456789-86922019-09-07T04:13:20Z Gαi proteins are indispensable for hearing Beer-Hammer, Sandra Lee, Sze Chim Mauriac, Stephanie A. Leiss, Veronika Groh, Isabel A. M. Novakovic, Ana Piekorz, Roland P. Bucher, Kirsten Chen, Chengfang Ni, Kun Singer, Wibke Harasztosi, Csaba Schimmang, Thomas Zimmermann, Ulrike Pfeffer, Klaus Birnbaumer, Lutz Forge, Andrew Montcouquiol, Mireille Knipper, Marlies Nürnberg, Bernd Rüttiger, Lukas GENES AUDICION PROTEINAS SORDERA PERDIDA AUDITIVA MODIFICIACION GENETICA Abstract: From invertebrates to mammals, Gαi proteins act together with their common binding partner Gpsm2 to govern cell polarization and planar organization in virtually any polarized cell. Recently, we demonstrated that Gαi3-deficiency in pre-hearing murine cochleae pointed to a role of Gαi3 for asymmetric migration of the kinocilium as well as the orientation and shape of the stereociliary ("hair") bundle, a requirement for the progression of mature hearing. We found that the lack of Gαi3 impairs stereociliary elongation and hair bundle shape in high-frequency cochlear regions, linked to elevated hearing thresholds for high-frequency sound. How these morphological defects translate into hearing phenotypes is not clear. 2019-09-06T16:46:08Z 2019-09-06T16:46:08Z 2018 Artículo Beer-Hammer S, Lee SC, Mauriac SA, et al. Gαi Proteins are Indispensable for Hearing [en línea]. Cellular Physiology and Biochemistry. 2018;47(4):1509-1532. doi:10.1159/000490867 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/8692 1015-8987 1421-9778 (online) https://repositorio.uca.edu.ar/handle/123456789/8692 10.1159/000490867 29940568 eng Acceso Abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Cellular Physiology and Biochemistry. 2018;47(4):1509-1532 |
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GENES AUDICION PROTEINAS SORDERA PERDIDA AUDITIVA MODIFICIACION GENETICA GENES AUDICION PROTEINAS SORDERA PERDIDA AUDITIVA MODIFICIACION GENETICA |
spellingShingle |
GENES AUDICION PROTEINAS SORDERA PERDIDA AUDITIVA MODIFICIACION GENETICA GENES AUDICION PROTEINAS SORDERA PERDIDA AUDITIVA MODIFICIACION GENETICA Beer-Hammer, Sandra Lee, Sze Chim Mauriac, Stephanie A. Leiss, Veronika Groh, Isabel A. M. Novakovic, Ana Piekorz, Roland P. Bucher, Kirsten Chen, Chengfang Ni, Kun Singer, Wibke Harasztosi, Csaba Schimmang, Thomas Zimmermann, Ulrike Pfeffer, Klaus Birnbaumer, Lutz Forge, Andrew Montcouquiol, Mireille Knipper, Marlies Nürnberg, Bernd Rüttiger, Lukas Gαi proteins are indispensable for hearing |
description |
Abstract: From invertebrates to mammals, Gαi proteins act together with their common binding partner Gpsm2 to govern cell polarization and planar organization in virtually any polarized cell. Recently, we demonstrated that Gαi3-deficiency in pre-hearing murine cochleae pointed to a role of Gαi3 for asymmetric migration of the kinocilium as well as the orientation and shape of the stereociliary ("hair") bundle, a requirement for the progression of mature hearing. We found that the lack of Gαi3 impairs stereociliary elongation and hair bundle shape in high-frequency cochlear regions, linked to elevated hearing thresholds for high-frequency sound. How these morphological defects translate into hearing phenotypes is not clear. |
format |
Artículo |
topic_facet |
GENES AUDICION PROTEINAS SORDERA PERDIDA AUDITIVA MODIFICIACION GENETICA |
author |
Beer-Hammer, Sandra Lee, Sze Chim Mauriac, Stephanie A. Leiss, Veronika Groh, Isabel A. M. Novakovic, Ana Piekorz, Roland P. Bucher, Kirsten Chen, Chengfang Ni, Kun Singer, Wibke Harasztosi, Csaba Schimmang, Thomas Zimmermann, Ulrike Pfeffer, Klaus Birnbaumer, Lutz Forge, Andrew Montcouquiol, Mireille Knipper, Marlies Nürnberg, Bernd Rüttiger, Lukas |
author_facet |
Beer-Hammer, Sandra Lee, Sze Chim Mauriac, Stephanie A. Leiss, Veronika Groh, Isabel A. M. Novakovic, Ana Piekorz, Roland P. Bucher, Kirsten Chen, Chengfang Ni, Kun Singer, Wibke Harasztosi, Csaba Schimmang, Thomas Zimmermann, Ulrike Pfeffer, Klaus Birnbaumer, Lutz Forge, Andrew Montcouquiol, Mireille Knipper, Marlies Nürnberg, Bernd Rüttiger, Lukas |
author_sort |
Beer-Hammer, Sandra |
title |
Gαi proteins are indispensable for hearing |
title_short |
Gαi proteins are indispensable for hearing |
title_full |
Gαi proteins are indispensable for hearing |
title_fullStr |
Gαi proteins are indispensable for hearing |
title_full_unstemmed |
Gαi proteins are indispensable for hearing |
title_sort |
gαi proteins are indispensable for hearing |
publishDate |
2018 |
url |
https://repositorio.uca.edu.ar/handle/123456789/8692 |
work_keys_str_mv |
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