Association of Per3 length polymorphism with bipolar I disorder and schizophrenia
Abstract: Sleep–wake disturbances have frequently been reported in bipolar disorder and schizophrenia, and are considered to be caused by an underlying circadian rhythm disorder. The study presented here was designed to investigate the existence of Per3 polymorphism in bipolar disorder type I (BD-I) and schizophrenic patients in South India. Methods: Blood samples were collected from 311 BD-I patients, 293 schizophrenia patients, and 346 age- and sex-matched normal controls. Per3 genotyping was performed on DNA by polymerase chain reaction using specific primers. Results: An increased prevalence of five repeat homozygotes was seen in BD-I patients as compared with healthy controls (odds ratio =1.72 [95% confidence interval: 1.08–2.76, P=0.02]). In BD-I patients, the frequency of the five repeat allele was higher (allele frequency =0.41), and that of the four repeat allele lower (allele frequency =0.36) (χ2=4.634; P,0.03) than in the control group. No significant association was observed in the allele frequencies of four and five repeat alleles in schizophrenia patients when compared with controls. Conclusion: The occurrence of the five repeat allele of Per3 may be a risk factor for BD-I onset in this ethnic group
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2014
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Subjects: | POLIMORFISMO, TRASTORNO BIPOLAR, ESQUIZOFRENIA, RITMOS BIOLOGICOS, RITMO CIRCADIANO, |
Online Access: | https://repositorio.uca.edu.ar/handle/123456789/1669 |
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oai:ucacris:123456789-16692022-03-18T20:02:46Z Association of Per3 length polymorphism with bipolar I disorder and schizophrenia Karthikeyan, Ramanujam Marimuthu, Ganapathy Ramasubramanian, Chellamuthu Arunachal, Gautham BaHammam, Ahmed S. Spence, David Warren Cardinali, Daniel Pedro Brown, Gregory M. Pandi Perumal, Seithikurippu R. POLIMORFISMO TRASTORNO BIPOLAR ESQUIZOFRENIA RITMOS BIOLOGICOS RITMO CIRCADIANO Abstract: Sleep–wake disturbances have frequently been reported in bipolar disorder and schizophrenia, and are considered to be caused by an underlying circadian rhythm disorder. The study presented here was designed to investigate the existence of Per3 polymorphism in bipolar disorder type I (BD-I) and schizophrenic patients in South India. Methods: Blood samples were collected from 311 BD-I patients, 293 schizophrenia patients, and 346 age- and sex-matched normal controls. Per3 genotyping was performed on DNA by polymerase chain reaction using specific primers. Results: An increased prevalence of five repeat homozygotes was seen in BD-I patients as compared with healthy controls (odds ratio =1.72 [95% confidence interval: 1.08–2.76, P=0.02]). In BD-I patients, the frequency of the five repeat allele was higher (allele frequency =0.41), and that of the four repeat allele lower (allele frequency =0.36) (χ2=4.634; P,0.03) than in the control group. No significant association was observed in the allele frequencies of four and five repeat alleles in schizophrenia patients when compared with controls. Conclusion: The occurrence of the five repeat allele of Per3 may be a risk factor for BD-I onset in this ethnic group 2019-05-02T14:01:20Z 2019-05-02T14:01:20Z 2014 Artículo Karthikeyan, R., et al. Association of Per3 length polymorphism with bipolar I disorder and schizophrenia [en línea]. Neuropsychiatric Disease and Treatment. 2014, 10. doi:10.2147/NDT.S73765. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1669 1176-6328 (impreso) 1178-2021 (online) https://repositorio.uca.edu.ar/handle/123456789/1669 10.2147/NDT.S73765 eng eng Acceso Abierto https://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Neuropsychiatric Disease and Treatment. 2014, 10 |
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POLIMORFISMO TRASTORNO BIPOLAR ESQUIZOFRENIA RITMOS BIOLOGICOS RITMO CIRCADIANO POLIMORFISMO TRASTORNO BIPOLAR ESQUIZOFRENIA RITMOS BIOLOGICOS RITMO CIRCADIANO |
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POLIMORFISMO TRASTORNO BIPOLAR ESQUIZOFRENIA RITMOS BIOLOGICOS RITMO CIRCADIANO POLIMORFISMO TRASTORNO BIPOLAR ESQUIZOFRENIA RITMOS BIOLOGICOS RITMO CIRCADIANO Karthikeyan, Ramanujam Marimuthu, Ganapathy Ramasubramanian, Chellamuthu Arunachal, Gautham BaHammam, Ahmed S. Spence, David Warren Cardinali, Daniel Pedro Brown, Gregory M. Pandi Perumal, Seithikurippu R. Association of Per3 length polymorphism with bipolar I disorder and schizophrenia |
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Abstract: Sleep–wake disturbances have frequently been reported in bipolar disorder and schizophrenia, and are considered to be caused by an underlying circadian rhythm disorder. The study presented here was designed to investigate the existence of Per3 polymorphism in bipolar disorder type I (BD-I) and schizophrenic patients in South India. Methods: Blood samples were collected from 311 BD-I patients, 293 schizophrenia patients, and 346 age- and sex-matched normal controls. Per3 genotyping was performed on DNA by polymerase chain reaction using specific primers. Results: An increased prevalence of five repeat homozygotes was seen in BD-I patients as compared with healthy controls (odds ratio =1.72 [95% confidence interval: 1.08–2.76, P=0.02]). In BD-I patients, the frequency of the five repeat allele was higher (allele frequency =0.41), and that of the four repeat allele lower (allele frequency =0.36) (χ2=4.634; P,0.03) than in the control group. No significant association was observed in the allele frequencies of four and five repeat alleles in schizophrenia patients when compared with controls. Conclusion: The occurrence of the five repeat allele of Per3 may be a risk factor for BD-I onset in this ethnic group |
format |
Artículo |
topic_facet |
POLIMORFISMO TRASTORNO BIPOLAR ESQUIZOFRENIA RITMOS BIOLOGICOS RITMO CIRCADIANO |
author |
Karthikeyan, Ramanujam Marimuthu, Ganapathy Ramasubramanian, Chellamuthu Arunachal, Gautham BaHammam, Ahmed S. Spence, David Warren Cardinali, Daniel Pedro Brown, Gregory M. Pandi Perumal, Seithikurippu R. |
author_facet |
Karthikeyan, Ramanujam Marimuthu, Ganapathy Ramasubramanian, Chellamuthu Arunachal, Gautham BaHammam, Ahmed S. Spence, David Warren Cardinali, Daniel Pedro Brown, Gregory M. Pandi Perumal, Seithikurippu R. |
author_sort |
Karthikeyan, Ramanujam |
title |
Association of Per3 length polymorphism with bipolar I disorder and schizophrenia |
title_short |
Association of Per3 length polymorphism with bipolar I disorder and schizophrenia |
title_full |
Association of Per3 length polymorphism with bipolar I disorder and schizophrenia |
title_fullStr |
Association of Per3 length polymorphism with bipolar I disorder and schizophrenia |
title_full_unstemmed |
Association of Per3 length polymorphism with bipolar I disorder and schizophrenia |
title_sort |
association of per3 length polymorphism with bipolar i disorder and schizophrenia |
publishDate |
2014 |
url |
https://repositorio.uca.edu.ar/handle/123456789/1669 |
work_keys_str_mv |
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