Melatonin : a pleiotropic, orchestrating regulator molecule
Abstract: Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues and cells. It acts via G protein-coupled receptors expressed in various areas of the central nervous system and in peripheral tissues. Parallel signaling mechanisms lead to cell-specific control and recruitment of downstream factors, including various kinases, transcription factors and ion channels. Additional actions via nuclear receptors and other binding sites are likely. By virtue of high receptor density in the circadian pacemaker, melatonin is involved in the phasing of circadian rhythms and sleep promotion. Additionally, it exerts effects on peripheral oscillators, including phase coupling of parallel cellular clocks based on alternate use of core oscillator proteins. Direct central and peripheral actions concern the up- or downregulation of various proteins, among which inducible and neuronal NO synthases seem to be of particular importance for antagonizing inflammation and excitotoxicity. The methoxyindole is also synthesized in several peripheral tissues, so that the total content of tissue melatonin exceeds by far the amounts in the circulation. Emerging fields in melatonin research concern receptor polymorphism in relation to various diseases, the control of sleep, the metabolic syndrome, weight control, diabetes type 2 and insulin resistance, and mitochondrial effects. Control of electron flux, prevention of bottlenecks in the respiratory chain and electron leakage contribute to the avoidance of damage by free radicals and seem to be important in neuroprotection, inflammatory diseases and, presumably, aging. Newly discovered influences on sirtuins and downstream factors indicate that melatonin has a role in mitochondrial biogenesis.
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Elsevier
2011
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Subjects: | MELATONINA, SUEÑO, ENVEJECIMIENTO, DIABETES, MITOCONDRIOS, RITMO CIRCADIANO, |
Online Access: | https://repositorio.uca.edu.ar/handle/123456789/1653 |
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oai:ucacris:123456789-16532020-08-19T22:01:02Z Melatonin : a pleiotropic, orchestrating regulator molecule Srinivasan, Venkataramanujan Pandi Perumal, Seithikurippu R. Brown, Gregory M. Cardinali, Daniel Pedro Spence, David Warren Hardeland, Rüdiger MELATONINA SUEÑO ENVEJECIMIENTO DIABETES MITOCONDRIOS RITMO CIRCADIANO Abstract: Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues and cells. It acts via G protein-coupled receptors expressed in various areas of the central nervous system and in peripheral tissues. Parallel signaling mechanisms lead to cell-specific control and recruitment of downstream factors, including various kinases, transcription factors and ion channels. Additional actions via nuclear receptors and other binding sites are likely. By virtue of high receptor density in the circadian pacemaker, melatonin is involved in the phasing of circadian rhythms and sleep promotion. Additionally, it exerts effects on peripheral oscillators, including phase coupling of parallel cellular clocks based on alternate use of core oscillator proteins. Direct central and peripheral actions concern the up- or downregulation of various proteins, among which inducible and neuronal NO synthases seem to be of particular importance for antagonizing inflammation and excitotoxicity. The methoxyindole is also synthesized in several peripheral tissues, so that the total content of tissue melatonin exceeds by far the amounts in the circulation. Emerging fields in melatonin research concern receptor polymorphism in relation to various diseases, the control of sleep, the metabolic syndrome, weight control, diabetes type 2 and insulin resistance, and mitochondrial effects. Control of electron flux, prevention of bottlenecks in the respiratory chain and electron leakage contribute to the avoidance of damage by free radicals and seem to be important in neuroprotection, inflammatory diseases and, presumably, aging. Newly discovered influences on sirtuins and downstream factors indicate that melatonin has a role in mitochondrial biogenesis. 2019-05-02T14:01:17Z 2019-05-02T14:01:17Z 2011 Artículo Srinivasan, V., et al. Melatonin : a pleiotropic, orchestrating regulator molecule [en línea]. Preprint de artículo publicado en Progress in Neurobiology. 2011, 93. doi:10.1016/j.pneurobio.2010.12.004. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1653 0301-0082 https://repositorio.uca.edu.ar/handle/123456789/1653 10.1016/j.pneurobio.2010.12.004 21193011 eng eng Acceso Abierto https://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Elsevier Progress in Neurobiology. 2011, 93 |
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MELATONINA SUEÑO ENVEJECIMIENTO DIABETES MITOCONDRIOS RITMO CIRCADIANO MELATONINA SUEÑO ENVEJECIMIENTO DIABETES MITOCONDRIOS RITMO CIRCADIANO |
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MELATONINA SUEÑO ENVEJECIMIENTO DIABETES MITOCONDRIOS RITMO CIRCADIANO MELATONINA SUEÑO ENVEJECIMIENTO DIABETES MITOCONDRIOS RITMO CIRCADIANO Srinivasan, Venkataramanujan Pandi Perumal, Seithikurippu R. Brown, Gregory M. Cardinali, Daniel Pedro Spence, David Warren Hardeland, Rüdiger Melatonin : a pleiotropic, orchestrating regulator molecule |
description |
Abstract: Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues and cells. It acts via G protein-coupled receptors expressed in various areas of the central nervous system and in peripheral tissues. Parallel signaling mechanisms lead to cell-specific control and recruitment of downstream factors, including various kinases, transcription factors and ion channels. Additional actions via nuclear receptors and other binding sites are likely. By virtue of high receptor density in the circadian pacemaker, melatonin is involved in the phasing of circadian rhythms and sleep promotion. Additionally, it exerts effects on peripheral oscillators, including phase coupling of parallel cellular clocks based on alternate use of core oscillator proteins. Direct central and peripheral actions concern the up- or downregulation of various proteins, among which inducible and neuronal NO synthases seem to be of particular importance for antagonizing inflammation and excitotoxicity. The methoxyindole is also synthesized in several peripheral tissues, so that the total content of tissue melatonin exceeds by far the amounts in the circulation. Emerging fields in melatonin research concern receptor polymorphism in relation to various diseases, the control of sleep, the metabolic syndrome, weight control, diabetes type 2 and insulin resistance, and mitochondrial effects. Control of electron flux, prevention of bottlenecks in the respiratory chain and electron leakage contribute to the avoidance of damage by free radicals and seem to be important in neuroprotection, inflammatory diseases and, presumably, aging. Newly discovered influences on sirtuins and downstream factors indicate that melatonin has a role in mitochondrial biogenesis. |
format |
Artículo |
topic_facet |
MELATONINA SUEÑO ENVEJECIMIENTO DIABETES MITOCONDRIOS RITMO CIRCADIANO |
author |
Srinivasan, Venkataramanujan Pandi Perumal, Seithikurippu R. Brown, Gregory M. Cardinali, Daniel Pedro Spence, David Warren Hardeland, Rüdiger |
author_facet |
Srinivasan, Venkataramanujan Pandi Perumal, Seithikurippu R. Brown, Gregory M. Cardinali, Daniel Pedro Spence, David Warren Hardeland, Rüdiger |
author_sort |
Srinivasan, Venkataramanujan |
title |
Melatonin : a pleiotropic, orchestrating regulator molecule |
title_short |
Melatonin : a pleiotropic, orchestrating regulator molecule |
title_full |
Melatonin : a pleiotropic, orchestrating regulator molecule |
title_fullStr |
Melatonin : a pleiotropic, orchestrating regulator molecule |
title_full_unstemmed |
Melatonin : a pleiotropic, orchestrating regulator molecule |
title_sort |
melatonin : a pleiotropic, orchestrating regulator molecule |
publisher |
Elsevier |
publishDate |
2011 |
url |
https://repositorio.uca.edu.ar/handle/123456789/1653 |
work_keys_str_mv |
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1756275066401718272 |