An exploratory study of sleep-wake differences of autonomic activity in patients with mild cognitive impairment : the role of melatonin as a modulating factor
Abstract: Purpose: The objective of the present study was to assess sleep-wake differences of autonomic activity in patients with mild cognitive impairment (MCI) compared to control subjects. As a post-hoc objective, we sought to evaluate the mediating effect of melatonin on this association. Patients and Methods: A total of 22 MCI patients (13 under melatonin treatment) and 12 control subjects were included in this study. Sleep-wake periods were identified by actigraphy and 24hr-heart rate variability measures were obtained to study sleep-wake autonomic activity. Results: MCI patients did not show any significant differences in sleep-wake autonomic activity when compared to control subjects. Post-hoc analyses revealed that MCI patients not taking melatonin displayed lower parasympathetic sleep-wake amplitude than controls not taking melatonin (RMSSD −7 ± 1 vs 4 ± 4, p = 0.004). In addition, we observed that melatonin treatment was associated with greater parasympathetic activity during sleep (VLF 15.5 ± 0.1 vs 15.1 ± 0.1, p = 0.010) and in sleep-wake differences in MCI patients (VLF 0.5 ± 0.1 vs 0.2 ± 0.0, p = 0.004). Conclusion: These preliminary findings hint at a possible sleep-related parasympathetic vulnerability in patients at prodromal stages of dementia as well as a potential protective effect of exogenous melatonin in this population.
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Dove Press
2023
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Subjects: | DETERIORO COGNITIVO LEVE, MELATONINA, ACTIGRAFIA, SUEÑO, RITMO CIRCADIANO, TRASTORNOS DEL SUEÑO, |
Online Access: | https://repositorio.uca.edu.ar/handle/123456789/16425 |
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oai:ucacris:123456789-164252023-11-23T17:47:14Z An exploratory study of sleep-wake differences of autonomic activity in patients with mild cognitive impairment : the role of melatonin as a modulating factor Abulafia, Carolina Andrea Vidal, María F. Olivar, Natividad Odzak, Andrea Brusco, Ignacio Guinjoan, Salvador M. Cardinali, Daniel Pedro Vigo, Daniel E. DETERIORO COGNITIVO LEVE MELATONINA ACTIGRAFIA SUEÑO RITMO CIRCADIANO TRASTORNOS DEL SUEÑO Abstract: Purpose: The objective of the present study was to assess sleep-wake differences of autonomic activity in patients with mild cognitive impairment (MCI) compared to control subjects. As a post-hoc objective, we sought to evaluate the mediating effect of melatonin on this association. Patients and Methods: A total of 22 MCI patients (13 under melatonin treatment) and 12 control subjects were included in this study. Sleep-wake periods were identified by actigraphy and 24hr-heart rate variability measures were obtained to study sleep-wake autonomic activity. Results: MCI patients did not show any significant differences in sleep-wake autonomic activity when compared to control subjects. Post-hoc analyses revealed that MCI patients not taking melatonin displayed lower parasympathetic sleep-wake amplitude than controls not taking melatonin (RMSSD −7 ± 1 vs 4 ± 4, p = 0.004). In addition, we observed that melatonin treatment was associated with greater parasympathetic activity during sleep (VLF 15.5 ± 0.1 vs 15.1 ± 0.1, p = 0.010) and in sleep-wake differences in MCI patients (VLF 0.5 ± 0.1 vs 0.2 ± 0.0, p = 0.004). Conclusion: These preliminary findings hint at a possible sleep-related parasympathetic vulnerability in patients at prodromal stages of dementia as well as a potential protective effect of exogenous melatonin in this population. 2023-05-30T12:06:59Z 2023-05-30T12:06:59Z 2023 Artículo Abulafia, C. A. et al. An exploratory study of sleep-wake differences of autonomic activity in patients with mild cognitive impairment : the role of melatonin as a modulating factor [en línea]. Clinical Interventions in Aging. 2023, 18. doi: 10.2147/CIA.S394749. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/16425 1178-1998 https://repositorio.uca.edu.ar/handle/123456789/16425 10.2147/CIA.S394749 37200894 eng Acceso abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Dove Press Clinical Interventions in Aging. Vol.18, 2023 |
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DETERIORO COGNITIVO LEVE MELATONINA ACTIGRAFIA SUEÑO RITMO CIRCADIANO TRASTORNOS DEL SUEÑO DETERIORO COGNITIVO LEVE MELATONINA ACTIGRAFIA SUEÑO RITMO CIRCADIANO TRASTORNOS DEL SUEÑO |
spellingShingle |
DETERIORO COGNITIVO LEVE MELATONINA ACTIGRAFIA SUEÑO RITMO CIRCADIANO TRASTORNOS DEL SUEÑO DETERIORO COGNITIVO LEVE MELATONINA ACTIGRAFIA SUEÑO RITMO CIRCADIANO TRASTORNOS DEL SUEÑO Abulafia, Carolina Andrea Vidal, María F. Olivar, Natividad Odzak, Andrea Brusco, Ignacio Guinjoan, Salvador M. Cardinali, Daniel Pedro Vigo, Daniel E. An exploratory study of sleep-wake differences of autonomic activity in patients with mild cognitive impairment : the role of melatonin as a modulating factor |
description |
Abstract: Purpose: The objective of the present study was to assess sleep-wake differences of autonomic activity in patients with mild cognitive
impairment (MCI) compared to control subjects. As a post-hoc objective, we sought to evaluate the mediating effect of melatonin on
this association.
Patients and Methods: A total of 22 MCI patients (13 under melatonin treatment) and 12 control subjects were included in this
study. Sleep-wake periods were identified by actigraphy and 24hr-heart rate variability measures were obtained to study sleep-wake
autonomic activity.
Results: MCI patients did not show any significant differences in sleep-wake autonomic activity when compared to control subjects.
Post-hoc analyses revealed that MCI patients not taking melatonin displayed lower parasympathetic sleep-wake amplitude than
controls not taking melatonin (RMSSD −7 ± 1 vs 4 ± 4, p = 0.004). In addition, we observed that melatonin treatment was associated
with greater parasympathetic activity during sleep (VLF 15.5 ± 0.1 vs 15.1 ± 0.1, p = 0.010) and in sleep-wake differences in MCI
patients (VLF 0.5 ± 0.1 vs 0.2 ± 0.0, p = 0.004).
Conclusion: These preliminary findings hint at a possible sleep-related parasympathetic vulnerability in patients at prodromal stages
of dementia as well as a potential protective effect of exogenous melatonin in this population. |
format |
Artículo |
topic_facet |
DETERIORO COGNITIVO LEVE MELATONINA ACTIGRAFIA SUEÑO RITMO CIRCADIANO TRASTORNOS DEL SUEÑO |
author |
Abulafia, Carolina Andrea Vidal, María F. Olivar, Natividad Odzak, Andrea Brusco, Ignacio Guinjoan, Salvador M. Cardinali, Daniel Pedro Vigo, Daniel E. |
author_facet |
Abulafia, Carolina Andrea Vidal, María F. Olivar, Natividad Odzak, Andrea Brusco, Ignacio Guinjoan, Salvador M. Cardinali, Daniel Pedro Vigo, Daniel E. |
author_sort |
Abulafia, Carolina Andrea |
title |
An exploratory study of sleep-wake differences of autonomic activity in patients with mild cognitive impairment : the role of melatonin as a modulating factor |
title_short |
An exploratory study of sleep-wake differences of autonomic activity in patients with mild cognitive impairment : the role of melatonin as a modulating factor |
title_full |
An exploratory study of sleep-wake differences of autonomic activity in patients with mild cognitive impairment : the role of melatonin as a modulating factor |
title_fullStr |
An exploratory study of sleep-wake differences of autonomic activity in patients with mild cognitive impairment : the role of melatonin as a modulating factor |
title_full_unstemmed |
An exploratory study of sleep-wake differences of autonomic activity in patients with mild cognitive impairment : the role of melatonin as a modulating factor |
title_sort |
exploratory study of sleep-wake differences of autonomic activity in patients with mild cognitive impairment : the role of melatonin as a modulating factor |
publisher |
Dove Press |
publishDate |
2023 |
url |
https://repositorio.uca.edu.ar/handle/123456789/16425 |
work_keys_str_mv |
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