Melatonin and the metabolic syndrome : physiopathologic and therapeutical implications
Abstract: Metabolic syndrome (MS) patients exhibit sleep/wake disturbances and other circadian abnormalities and these may be associated with more rapid weight increase and development of diabetes and atherosclerotic disease. On this basis, the successful management of MS may require an ideal drug that besides antagonizing the trigger factors of MS could also correct the disturbed sleep‐wake rhythm. Melatonin is an effective chronobiotic agent able to change the phase and amplitude of circadian rhythms. Melatonin has also significant cytoprotective properties preventing a number of MS sequela in animal models of diabetes and obesity. A small number of controlled trials indicate that melatonin is useful to treat the metabolic and cardiovascular comorbilities of MS. Whether the recently introduced melatonergic agents (ramelteon, agomelatine, tasimelteon) have the potential for treating sleep disorders in MS patients and, more generally, for arresting the progression of disease merits further investigation.
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Language: | eng eng |
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Karger Publishers
2011
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Subjects: | MELATONINA, RITMO CIRCADIANO, SINDROME METABOLICO, AGONISTAS, |
Online Access: | https://repositorio.uca.edu.ar/handle/123456789/1619 |
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oai:ucacris:123456789-16192020-08-19T22:19:27Z Melatonin and the metabolic syndrome : physiopathologic and therapeutical implications Cardinali, Daniel Pedro Cano Barquilla, Pilar Jiménez Ortega, Vanesa Esquifino, Ana I. MELATONINA RITMO CIRCADIANO SINDROME METABOLICO AGONISTAS Abstract: Metabolic syndrome (MS) patients exhibit sleep/wake disturbances and other circadian abnormalities and these may be associated with more rapid weight increase and development of diabetes and atherosclerotic disease. On this basis, the successful management of MS may require an ideal drug that besides antagonizing the trigger factors of MS could also correct the disturbed sleep‐wake rhythm. Melatonin is an effective chronobiotic agent able to change the phase and amplitude of circadian rhythms. Melatonin has also significant cytoprotective properties preventing a number of MS sequela in animal models of diabetes and obesity. A small number of controlled trials indicate that melatonin is useful to treat the metabolic and cardiovascular comorbilities of MS. Whether the recently introduced melatonergic agents (ramelteon, agomelatine, tasimelteon) have the potential for treating sleep disorders in MS patients and, more generally, for arresting the progression of disease merits further investigation. 2019-05-02T14:01:08Z 2019-05-02T14:01:08Z 2011 Artículo Cardinali, D. P., et al. Melatonin and the metabolic syndrome : physiopathologic and therapeutical implications [en línea]. Preprint de artículo publicado en Neuroendocrinology. 2011, 93 (3). doi:10.1159/000324699. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1619 0028-3835 (Print) 1423-0194 (Online) https://repositorio.uca.edu.ar/handle/123456789/1619 10.1159/000324699 eng eng Acceso Abierto https://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Karger Publishers Neuroendocrinology 2011, 93 (3) |
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MELATONINA RITMO CIRCADIANO SINDROME METABOLICO AGONISTAS MELATONINA RITMO CIRCADIANO SINDROME METABOLICO AGONISTAS |
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MELATONINA RITMO CIRCADIANO SINDROME METABOLICO AGONISTAS MELATONINA RITMO CIRCADIANO SINDROME METABOLICO AGONISTAS Cardinali, Daniel Pedro Cano Barquilla, Pilar Jiménez Ortega, Vanesa Esquifino, Ana I. Melatonin and the metabolic syndrome : physiopathologic and therapeutical implications |
description |
Abstract: Metabolic syndrome (MS) patients exhibit sleep/wake disturbances and other circadian abnormalities and these may be associated with more rapid weight increase and development of diabetes and atherosclerotic disease. On this basis, the successful management of MS may require an ideal drug that besides antagonizing the trigger factors of MS could also correct the disturbed sleep‐wake rhythm. Melatonin is an effective chronobiotic agent able to change the phase and amplitude of circadian rhythms. Melatonin has also significant cytoprotective properties preventing a number of MS sequela in animal models of diabetes and obesity. A small number of controlled trials indicate that melatonin is useful to treat the metabolic and cardiovascular comorbilities of MS. Whether the recently introduced melatonergic agents (ramelteon, agomelatine, tasimelteon) have the potential for treating sleep disorders in MS patients and, more generally, for arresting the progression of disease merits further investigation. |
format |
Artículo |
topic_facet |
MELATONINA RITMO CIRCADIANO SINDROME METABOLICO AGONISTAS |
author |
Cardinali, Daniel Pedro Cano Barquilla, Pilar Jiménez Ortega, Vanesa Esquifino, Ana I. |
author_facet |
Cardinali, Daniel Pedro Cano Barquilla, Pilar Jiménez Ortega, Vanesa Esquifino, Ana I. |
author_sort |
Cardinali, Daniel Pedro |
title |
Melatonin and the metabolic syndrome : physiopathologic and therapeutical implications |
title_short |
Melatonin and the metabolic syndrome : physiopathologic and therapeutical implications |
title_full |
Melatonin and the metabolic syndrome : physiopathologic and therapeutical implications |
title_fullStr |
Melatonin and the metabolic syndrome : physiopathologic and therapeutical implications |
title_full_unstemmed |
Melatonin and the metabolic syndrome : physiopathologic and therapeutical implications |
title_sort |
melatonin and the metabolic syndrome : physiopathologic and therapeutical implications |
publisher |
Karger Publishers |
publishDate |
2011 |
url |
https://repositorio.uca.edu.ar/handle/123456789/1619 |
work_keys_str_mv |
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_version_ |
1756275061876064256 |