Contribution of TRPC channels in neuronal excitotoxicity associated with neurodegenerative disease and ischemic stroke
Abstract: The seven canonical members of transient receptor potential (TRPC) proteins form cation channels that evoke membrane depolarization and intracellular calcium concentration ([Ca2C]i) rise, which are not only important for regulating cell function but their deregulation can also lead to cell damage. Recent studies have implicated complex roles of TRPC channels in neurodegenerative diseases including ischemic stroke. Brain ischemia reduces oxygen and glucose supply to neurons, i.e., Oxygen and Glucose Deprivation (OGD), resulting in [Ca2C]i elevation, ion dyshomeostasis, and excitotoxicity, which are also common in many forms of neurodegenerative diseases. Although ionotropic glutamate receptors, e.g., N-methyl-D-aspartate receptors, are well established to play roles in excitotoxicity, the contribution of metabotropic glutamate receptors and their downstream effectors, i.e., TRPC channels, should not be neglected. Here, we summarize the current findings about contributions of TRPC channels in neurodegenerative diseases, with a focus on OGD-induced neuronal death and rodent models of cerebral ischemia/reperfusion. TRPC channels play both detrimental and protective roles to neurodegeneration depending on the TRPC subtype and specific pathological conditions involved. When illustrated the mechanisms by which TRPC channels are involved in neuronal survival or death seem differ greatly, implicating diverse and complex regulation. We provide our own data showing that TRPC1/C4/C5, especially TRPC4, may be generally detrimental in OGD and cerebral ischemia/reperfusion. We propose that although TRPC channels significantly contribute to ischemic neuronal death, detailed mechanisms and specific roles of TRPC subtypes in brain injury at different stages of ischemia/reperfusion and in different brain regions need to be carefully and systematically investigated.
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Lausanne: Frontiers Media
2021
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Subjects: | TRCP, FISIOPATOLOGÍA, ENFERMEDADES NEURODEGENERATIVAS, ACCIDENTE CEREBROVASCULAR, LESION CEREBRAL, |
Online Access: | https://repositorio.uca.edu.ar/handle/123456789/11624 |
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oai:ucacris:123456789-116242023-11-22T21:51:11Z Contribution of TRPC channels in neuronal excitotoxicity associated with neurodegenerative disease and ischemic stroke Jeon, Jaepyo Bu, Fan Sun, Guanghua Tian, Jin-Bin Ting, Shun-Ming Li, Jun Aronowski, Jaroslaw Birnbaumer, Lutz Freichel, Marc Zhu, Michael X. TRCP FISIOPATOLOGÍA ENFERMEDADES NEURODEGENERATIVAS ACCIDENTE CEREBROVASCULAR LESION CEREBRAL Abstract: The seven canonical members of transient receptor potential (TRPC) proteins form cation channels that evoke membrane depolarization and intracellular calcium concentration ([Ca2C]i) rise, which are not only important for regulating cell function but their deregulation can also lead to cell damage. Recent studies have implicated complex roles of TRPC channels in neurodegenerative diseases including ischemic stroke. Brain ischemia reduces oxygen and glucose supply to neurons, i.e., Oxygen and Glucose Deprivation (OGD), resulting in [Ca2C]i elevation, ion dyshomeostasis, and excitotoxicity, which are also common in many forms of neurodegenerative diseases. Although ionotropic glutamate receptors, e.g., N-methyl-D-aspartate receptors, are well established to play roles in excitotoxicity, the contribution of metabotropic glutamate receptors and their downstream effectors, i.e., TRPC channels, should not be neglected. Here, we summarize the current findings about contributions of TRPC channels in neurodegenerative diseases, with a focus on OGD-induced neuronal death and rodent models of cerebral ischemia/reperfusion. TRPC channels play both detrimental and protective roles to neurodegeneration depending on the TRPC subtype and specific pathological conditions involved. When illustrated the mechanisms by which TRPC channels are involved in neuronal survival or death seem differ greatly, implicating diverse and complex regulation. We provide our own data showing that TRPC1/C4/C5, especially TRPC4, may be generally detrimental in OGD and cerebral ischemia/reperfusion. We propose that although TRPC channels significantly contribute to ischemic neuronal death, detailed mechanisms and specific roles of TRPC subtypes in brain injury at different stages of ischemia/reperfusion and in different brain regions need to be carefully and systematically investigated. 2021-06-15T13:07:19Z 2021-06-15T13:07:19Z 2021 Artículo Jeon, J., et al. Contribution of TRPC channels in neuronal excitotoxicity associated with neurodegenerative disease and ischemic stroke [en línea]. Frontiers in cell and developmental biology. 2021, 8. doi: 10.3389/fcell.2020.618663. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/11624 2296-634X (on line) https://repositorio.uca.edu.ar/handle/123456789/11624 10.3389/fcell.2020.618663 33490083 eng Acceso abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Lausanne: Frontiers Media Frontiers in cell and developmental biology. 2021, 8 |
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TRCP FISIOPATOLOGÍA ENFERMEDADES NEURODEGENERATIVAS ACCIDENTE CEREBROVASCULAR LESION CEREBRAL TRCP FISIOPATOLOGÍA ENFERMEDADES NEURODEGENERATIVAS ACCIDENTE CEREBROVASCULAR LESION CEREBRAL |
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TRCP FISIOPATOLOGÍA ENFERMEDADES NEURODEGENERATIVAS ACCIDENTE CEREBROVASCULAR LESION CEREBRAL TRCP FISIOPATOLOGÍA ENFERMEDADES NEURODEGENERATIVAS ACCIDENTE CEREBROVASCULAR LESION CEREBRAL Jeon, Jaepyo Bu, Fan Sun, Guanghua Tian, Jin-Bin Ting, Shun-Ming Li, Jun Aronowski, Jaroslaw Birnbaumer, Lutz Freichel, Marc Zhu, Michael X. Contribution of TRPC channels in neuronal excitotoxicity associated with neurodegenerative disease and ischemic stroke |
description |
Abstract: The seven canonical members of transient receptor potential (TRPC) proteins
form cation channels that evoke membrane depolarization and intracellular calcium
concentration ([Ca2C]i) rise, which are not only important for regulating cell function
but their deregulation can also lead to cell damage. Recent studies have implicated
complex roles of TRPC channels in neurodegenerative diseases including ischemic
stroke. Brain ischemia reduces oxygen and glucose supply to neurons, i.e., Oxygen
and Glucose Deprivation (OGD), resulting in [Ca2C]i elevation, ion dyshomeostasis, and
excitotoxicity, which are also common in many forms of neurodegenerative diseases.
Although ionotropic glutamate receptors, e.g., N-methyl-D-aspartate receptors, are
well established to play roles in excitotoxicity, the contribution of metabotropic
glutamate receptors and their downstream effectors, i.e., TRPC channels, should
not be neglected. Here, we summarize the current findings about contributions of
TRPC channels in neurodegenerative diseases, with a focus on OGD-induced neuronal
death and rodent models of cerebral ischemia/reperfusion. TRPC channels play both
detrimental and protective roles to neurodegeneration depending on the TRPC subtype
and specific pathological conditions involved. When illustrated the mechanisms by
which TRPC channels are involved in neuronal survival or death seem differ greatly,
implicating diverse and complex regulation. We provide our own data showing that
TRPC1/C4/C5, especially TRPC4, may be generally detrimental in OGD and cerebral
ischemia/reperfusion. We propose that although TRPC channels significantly contribute
to ischemic neuronal death, detailed mechanisms and specific roles of TRPC subtypes
in brain injury at different stages of ischemia/reperfusion and in different brain regions
need to be carefully and systematically investigated. |
format |
Artículo |
topic_facet |
TRCP FISIOPATOLOGÍA ENFERMEDADES NEURODEGENERATIVAS ACCIDENTE CEREBROVASCULAR LESION CEREBRAL |
author |
Jeon, Jaepyo Bu, Fan Sun, Guanghua Tian, Jin-Bin Ting, Shun-Ming Li, Jun Aronowski, Jaroslaw Birnbaumer, Lutz Freichel, Marc Zhu, Michael X. |
author_facet |
Jeon, Jaepyo Bu, Fan Sun, Guanghua Tian, Jin-Bin Ting, Shun-Ming Li, Jun Aronowski, Jaroslaw Birnbaumer, Lutz Freichel, Marc Zhu, Michael X. |
author_sort |
Jeon, Jaepyo |
title |
Contribution of TRPC channels in neuronal excitotoxicity associated with neurodegenerative disease and ischemic stroke |
title_short |
Contribution of TRPC channels in neuronal excitotoxicity associated with neurodegenerative disease and ischemic stroke |
title_full |
Contribution of TRPC channels in neuronal excitotoxicity associated with neurodegenerative disease and ischemic stroke |
title_fullStr |
Contribution of TRPC channels in neuronal excitotoxicity associated with neurodegenerative disease and ischemic stroke |
title_full_unstemmed |
Contribution of TRPC channels in neuronal excitotoxicity associated with neurodegenerative disease and ischemic stroke |
title_sort |
contribution of trpc channels in neuronal excitotoxicity associated with neurodegenerative disease and ischemic stroke |
publisher |
Lausanne: Frontiers Media |
publishDate |
2021 |
url |
https://repositorio.uca.edu.ar/handle/123456789/11624 |
work_keys_str_mv |
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