Influence of prenatal stress on metabolic abnormalities induced by postnatal intake of a high-fat diet in BALB/c mice
Abstract: Prenatal insults during fetal development result in increased likelihood of developing chronic disease. Obesity, the biggest risk factor for the development of metabolic disease, is affected by several genetic and environmental factors. High-fat diet (HFD) consumption is usually linked with the development of obesity. The main goal of this study was to analyze the impact of the exposure to a HFD in prenatally stressed animals. For this purpose, we subjected pregnant BALB/c mice to restraint stress for 2 h a day between gestational day (GD) 14 and GD 21. Prenatally stressed and control offspring of both sexes were postnatally exposed to a HFD for 24 weeks. We found that prenatal stress (PS) per se produced disturbances in males such as increased total blood cholesterol and triglycerides, with a decrease in mRNA expression of sirtuin-1.When these animals were fed a HFD, we observed a rise in glucose and insulin levels and an increase in visceral adipose tissue gene expression of leptin, resistin, and interleukin-1 beta. Although females proved to be more resilient to PS consequences, when they were fed a HFD, they showed significant metabolic impairment. In addition to the changes observed in males, females also presented an increase in body weight and adiposity and a rise in cholesterol levels.
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Cambridge University Press
2020
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Subjects: | STRESS PRENATAL, OBESIDAD, METABOLISMO, GENES, |
Online Access: | https://repositorio.uca.edu.ar/handle/123456789/11564 |
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oai:ucacris:123456789-115642024-03-12T10:41:20Z Influence of prenatal stress on metabolic abnormalities induced by postnatal intake of a high-fat diet in BALB/c mice Juárez, Yamila R. Quiroga, Sofía Prochnik, Andrés Wald, Miriam Ruth Tellechea, Mariana L. Genaro, Ana María Burgueño, Adriana Laura STRESS PRENATAL OBESIDAD METABOLISMO GENES Abstract: Prenatal insults during fetal development result in increased likelihood of developing chronic disease. Obesity, the biggest risk factor for the development of metabolic disease, is affected by several genetic and environmental factors. High-fat diet (HFD) consumption is usually linked with the development of obesity. The main goal of this study was to analyze the impact of the exposure to a HFD in prenatally stressed animals. For this purpose, we subjected pregnant BALB/c mice to restraint stress for 2 h a day between gestational day (GD) 14 and GD 21. Prenatally stressed and control offspring of both sexes were postnatally exposed to a HFD for 24 weeks. We found that prenatal stress (PS) per se produced disturbances in males such as increased total blood cholesterol and triglycerides, with a decrease in mRNA expression of sirtuin-1.When these animals were fed a HFD, we observed a rise in glucose and insulin levels and an increase in visceral adipose tissue gene expression of leptin, resistin, and interleukin-1 beta. Although females proved to be more resilient to PS consequences, when they were fed a HFD, they showed significant metabolic impairment. In addition to the changes observed in males, females also presented an increase in body weight and adiposity and a rise in cholesterol levels. 2021-05-27T14:02:24Z 2021-05-27T14:02:24Z 2020 Artículo Juárez Y.R., Quiroga S., Prochnik A., Wald M., Tellechea M.L., Genaro A.M., Burgueño A.L. Influence of prenatal stress on metabolic abnormalities induced by postnatal intake of a high-fat diet in BALB/c miceJ [en línea]. Postprint del artículo publicado en: Journal of Developmental Origins of Health and Disease. 2020. Doi: 10.1017/ S2040174420000987. Disponible en: 2040-1752 (en línea) https://repositorio.uca.edu.ar/handle/123456789/11564 10.1017/ S2040174420000987 33118903 eng Acceso abierto. 6 meses de embargo http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Cambridge University Press Postprint del artículo publicado en: Journal of Developmental Origins of Health and Disease. 2020 |
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STRESS PRENATAL OBESIDAD METABOLISMO GENES STRESS PRENATAL OBESIDAD METABOLISMO GENES |
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STRESS PRENATAL OBESIDAD METABOLISMO GENES STRESS PRENATAL OBESIDAD METABOLISMO GENES Juárez, Yamila R. Quiroga, Sofía Prochnik, Andrés Wald, Miriam Ruth Tellechea, Mariana L. Genaro, Ana María Burgueño, Adriana Laura Influence of prenatal stress on metabolic abnormalities induced by postnatal intake of a high-fat diet in BALB/c mice |
description |
Abstract: Prenatal insults during fetal development result in increased likelihood of developing chronic
disease. Obesity, the biggest risk factor for the development of metabolic disease, is affected by
several genetic and environmental factors. High-fat diet (HFD) consumption is usually linked
with the development of obesity. The main goal of this study was to analyze the impact of the
exposure to a HFD in prenatally stressed animals. For this purpose, we subjected pregnant
BALB/c mice to restraint stress for 2 h a day between gestational day (GD) 14 and GD 21.
Prenatally stressed and control offspring of both sexes were postnatally exposed to a HFD
for 24 weeks. We found that prenatal stress (PS) per se produced disturbances in males such
as increased total blood cholesterol and triglycerides, with a decrease in mRNA expression of
sirtuin-1.When these animals were fed a HFD, we observed a rise in glucose and insulin levels
and an increase in visceral adipose tissue gene expression of leptin, resistin, and interleukin-1
beta. Although females proved to be more resilient to PS consequences, when they were fed a
HFD, they showed significant metabolic impairment. In addition to the changes observed in
males, females also presented an increase in body weight and adiposity and a rise in cholesterol
levels. |
format |
Artículo |
topic_facet |
STRESS PRENATAL OBESIDAD METABOLISMO GENES |
author |
Juárez, Yamila R. Quiroga, Sofía Prochnik, Andrés Wald, Miriam Ruth Tellechea, Mariana L. Genaro, Ana María Burgueño, Adriana Laura |
author_facet |
Juárez, Yamila R. Quiroga, Sofía Prochnik, Andrés Wald, Miriam Ruth Tellechea, Mariana L. Genaro, Ana María Burgueño, Adriana Laura |
author_sort |
Juárez, Yamila R. |
title |
Influence of prenatal stress on metabolic abnormalities induced by postnatal intake of a high-fat diet in BALB/c mice |
title_short |
Influence of prenatal stress on metabolic abnormalities induced by postnatal intake of a high-fat diet in BALB/c mice |
title_full |
Influence of prenatal stress on metabolic abnormalities induced by postnatal intake of a high-fat diet in BALB/c mice |
title_fullStr |
Influence of prenatal stress on metabolic abnormalities induced by postnatal intake of a high-fat diet in BALB/c mice |
title_full_unstemmed |
Influence of prenatal stress on metabolic abnormalities induced by postnatal intake of a high-fat diet in BALB/c mice |
title_sort |
influence of prenatal stress on metabolic abnormalities induced by postnatal intake of a high-fat diet in balb/c mice |
publisher |
Cambridge University Press |
publishDate |
2020 |
url |
https://repositorio.uca.edu.ar/handle/123456789/11564 |
work_keys_str_mv |
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