Esomeprazole-induced lichen planus

Esomeprazole-induced lichen planus

Abstract Introduction: Lichenoid drug eruption (LDE) is an uncommon cutaneous drug reaction (CDR) that has classically been associated with anti-hypertensive drugs, gold, and penicillamine. Case presentation: We present the case of a 63-year-old woman who developed a pruriginous disseminated dermatosis composed of violaceous polygonal flat-topped papules affecting the flexural aspects of the upper and lower limbs, abdominal flanks, and the lumbar and sacral regions. The lesions started 2 weeks after initiating esomeprazole intake. A histopathological exam of one of the lesions was compatible with LDE. The patient discontinued esomeprazole and was treated with medium potency topical corticosteroids and emollient with full resolution of symptoms. Conclusion: Even though CDRs associated with proton-pump inhibitors (PPI) are relatively common, there are only three reported cases of LDE. We report this case to highlight the importance of considering PPIs as the culprit drug in similar clinical situations.

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Main Authors: Santos-Coelho,Miguel, Barbosa,Joana A., João,Alexandre, Araújo-Carvalho,Rodrigo
Format: Digital revista
Language:English
Published: Permanyer Publications 2023
Online Access:http://scielo.pt/scielo.php?script=sci_arttext&pid=S2795-50012023000200129
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spelling oai:scielo:S2795-500120230002001292024-02-28Esomeprazole-induced lichen planusSantos-Coelho,MiguelBarbosa,Joana A.João,AlexandreAraújo-Carvalho,Rodrigo Lichenoid drug eruption Proton-pump inhibitors Esomeprazole Abstract Introduction: Lichenoid drug eruption (LDE) is an uncommon cutaneous drug reaction (CDR) that has classically been associated with anti-hypertensive drugs, gold, and penicillamine. Case presentation: We present the case of a 63-year-old woman who developed a pruriginous disseminated dermatosis composed of violaceous polygonal flat-topped papules affecting the flexural aspects of the upper and lower limbs, abdominal flanks, and the lumbar and sacral regions. The lesions started 2 weeks after initiating esomeprazole intake. A histopathological exam of one of the lesions was compatible with LDE. The patient discontinued esomeprazole and was treated with medium potency topical corticosteroids and emollient with full resolution of symptoms. Conclusion: Even though CDRs associated with proton-pump inhibitors (PPI) are relatively common, there are only three reported cases of LDE. We report this case to highlight the importance of considering PPIs as the culprit drug in similar clinical situations.info:eu-repo/semantics/openAccessPermanyer PublicationsPortuguese Journal of Dermatology and Venereology v.81 n.2 20232023-06-01info:eu-repo/semantics/reporttext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S2795-50012023000200129en10.24875/pjdv.22000043
institution SCIELO
collection OJS
country Portugal
countrycode PT
component Revista
access En linea
databasecode rev-scielo-pt
tag revista
region Europa del Sur
libraryname SciELO
language English
format Digital
author Santos-Coelho,Miguel
Barbosa,Joana A.
João,Alexandre
Araújo-Carvalho,Rodrigo
spellingShingle Santos-Coelho,Miguel
Barbosa,Joana A.
João,Alexandre
Araújo-Carvalho,Rodrigo
Esomeprazole-induced lichen planus
author_facet Santos-Coelho,Miguel
Barbosa,Joana A.
João,Alexandre
Araújo-Carvalho,Rodrigo
author_sort Santos-Coelho,Miguel
title Esomeprazole-induced lichen planus
title_short Esomeprazole-induced lichen planus
title_full Esomeprazole-induced lichen planus
title_fullStr Esomeprazole-induced lichen planus
title_full_unstemmed Esomeprazole-induced lichen planus
title_sort esomeprazole-induced lichen planus
description Abstract Introduction: Lichenoid drug eruption (LDE) is an uncommon cutaneous drug reaction (CDR) that has classically been associated with anti-hypertensive drugs, gold, and penicillamine. Case presentation: We present the case of a 63-year-old woman who developed a pruriginous disseminated dermatosis composed of violaceous polygonal flat-topped papules affecting the flexural aspects of the upper and lower limbs, abdominal flanks, and the lumbar and sacral regions. The lesions started 2 weeks after initiating esomeprazole intake. A histopathological exam of one of the lesions was compatible with LDE. The patient discontinued esomeprazole and was treated with medium potency topical corticosteroids and emollient with full resolution of symptoms. Conclusion: Even though CDRs associated with proton-pump inhibitors (PPI) are relatively common, there are only three reported cases of LDE. We report this case to highlight the importance of considering PPIs as the culprit drug in similar clinical situations.
publisher Permanyer Publications
publishDate 2023
url http://scielo.pt/scielo.php?script=sci_arttext&pid=S2795-50012023000200129
work_keys_str_mv AT santoscoelhomiguel esomeprazoleinducedlichenplanus
AT barbosajoanaa esomeprazoleinducedlichenplanus
AT joaoalexandre esomeprazoleinducedlichenplanus
AT araujocarvalhorodrigo esomeprazoleinducedlichenplanus
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