Tapentadol: what every doctor needs to know about this new drug
ABSTRACT BACKGROUND AND OBJECTIVES: Acute and chronic pain is a major problem with repercussion in our society, causing impairment in the quality of life of patients as well as socioeconomic losses, due to work absenteeism. This review aims to analyze the use of tapentadol, an analgesic not yet available in Brazil, with a dual mechanism of action, in the treatment of acute and chronic pain syndromes. CONTENTS: A review about this new drug was made on the Pubmed database using the keywords "tapentadol" and "opioids," evaluating its pharmacological and clinical aspects comparing with other current drugs in pain treatment, as well as its indications and contraindications in the management of patients with pain disorders. CONCLUSION: Tapentadol has been shown to be effective in the treatment of acute and chronic pain, with potency equivalent to the opioids currently used. In addition, it developed less tolerance, less adverse effects and better therapeutic response in chronic neuropathic pain when compared to pure µ-opioid receptors agonists.
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Sociedade Brasileira para o Estudo da Dor
2018
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oai:scielo:S2595-319220180001000722018-06-04Tapentadol: what every doctor needs to know about this new drugMosele,Bernardo De MarchiAlmeida,Daniel Benzecry deHess,Válery Baggio Dual mechanism of action Opioids Tapentadol ABSTRACT BACKGROUND AND OBJECTIVES: Acute and chronic pain is a major problem with repercussion in our society, causing impairment in the quality of life of patients as well as socioeconomic losses, due to work absenteeism. This review aims to analyze the use of tapentadol, an analgesic not yet available in Brazil, with a dual mechanism of action, in the treatment of acute and chronic pain syndromes. CONTENTS: A review about this new drug was made on the Pubmed database using the keywords "tapentadol" and "opioids," evaluating its pharmacological and clinical aspects comparing with other current drugs in pain treatment, as well as its indications and contraindications in the management of patients with pain disorders. CONCLUSION: Tapentadol has been shown to be effective in the treatment of acute and chronic pain, with potency equivalent to the opioids currently used. In addition, it developed less tolerance, less adverse effects and better therapeutic response in chronic neuropathic pain when compared to pure µ-opioid receptors agonists.info:eu-repo/semantics/openAccessSociedade Brasileira para o Estudo da DorBrJP v.1 n.1 20182018-03-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2595-31922018000100072en10.5935/2595-0118.20180015 |
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Mosele,Bernardo De Marchi Almeida,Daniel Benzecry de Hess,Válery Baggio |
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Mosele,Bernardo De Marchi Almeida,Daniel Benzecry de Hess,Válery Baggio Tapentadol: what every doctor needs to know about this new drug |
| author_facet |
Mosele,Bernardo De Marchi Almeida,Daniel Benzecry de Hess,Válery Baggio |
| author_sort |
Mosele,Bernardo De Marchi |
| title |
Tapentadol: what every doctor needs to know about this new drug |
| title_short |
Tapentadol: what every doctor needs to know about this new drug |
| title_full |
Tapentadol: what every doctor needs to know about this new drug |
| title_fullStr |
Tapentadol: what every doctor needs to know about this new drug |
| title_full_unstemmed |
Tapentadol: what every doctor needs to know about this new drug |
| title_sort |
tapentadol: what every doctor needs to know about this new drug |
| description |
ABSTRACT BACKGROUND AND OBJECTIVES: Acute and chronic pain is a major problem with repercussion in our society, causing impairment in the quality of life of patients as well as socioeconomic losses, due to work absenteeism. This review aims to analyze the use of tapentadol, an analgesic not yet available in Brazil, with a dual mechanism of action, in the treatment of acute and chronic pain syndromes. CONTENTS: A review about this new drug was made on the Pubmed database using the keywords "tapentadol" and "opioids," evaluating its pharmacological and clinical aspects comparing with other current drugs in pain treatment, as well as its indications and contraindications in the management of patients with pain disorders. CONCLUSION: Tapentadol has been shown to be effective in the treatment of acute and chronic pain, with potency equivalent to the opioids currently used. In addition, it developed less tolerance, less adverse effects and better therapeutic response in chronic neuropathic pain when compared to pure µ-opioid receptors agonists. |
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Sociedade Brasileira para o Estudo da Dor |
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2018 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2595-31922018000100072 |
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