Anal tumors with infrequent histology: Analysis of a series of cases and literature review

Background: The most frequent tumor of the anal region is epidermoid carcinoma; however, other types of tumors such as melanomas, sarcomas, and lymphomas can also develop. Most of them present similar symptoms although diagnosis and prognosis might be radically different. Objective: The objective of this study was to report the clinical and histopathological characteristics of a group of patients diagnosed with non-epidermoid anal neoplasm in a third-level hospital. Materials and Methods: Eight patients with non-epidermoid anal neoplastic biopsy samples were evaluated from March 2013 to January 2017. Demographic data and histopathological results were obtained from the clinical records. Results: Mean age of the patients was 48.9 years (23-84); 37.5% of women and 62.5% of men. Patients presented with rectal bleeding in 25%, anal pain 87.5%, anal tumor 75%, and fever 25%. Among the patients, 37.5% presented with melanoma and 62.5% lymphoma. Regarding patients with lymphoma, 60% had plasmablastic lymphoma and 40% non-Hodgkin's lymphoma. The diagnostic time was 4 months on average (1-8 months) and 25% of the patients had been previously misdiagnosed with hemorrhoidal disease. Conclusion: Non-epidermoid anal neoplasm cases are infrequent and its accurate diagnosis can take months, therefore, changing prognosis.

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Bibliographic Details
Main Authors: Sordo-Mejía,Ricardo, Villanueva-Herrero,Juan A., González-Macedo,Edgar, Sandoval-Martínez,Marco D., Nuñez-García,Edgar, Jiménez-Bobadilla,Billy
Format: Digital revista
Language:English
Published: Sociedad Médica del Hospital General de México A.C. 2019
Online Access:http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S2524-177X2019000300147
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Summary:Background: The most frequent tumor of the anal region is epidermoid carcinoma; however, other types of tumors such as melanomas, sarcomas, and lymphomas can also develop. Most of them present similar symptoms although diagnosis and prognosis might be radically different. Objective: The objective of this study was to report the clinical and histopathological characteristics of a group of patients diagnosed with non-epidermoid anal neoplasm in a third-level hospital. Materials and Methods: Eight patients with non-epidermoid anal neoplastic biopsy samples were evaluated from March 2013 to January 2017. Demographic data and histopathological results were obtained from the clinical records. Results: Mean age of the patients was 48.9 years (23-84); 37.5% of women and 62.5% of men. Patients presented with rectal bleeding in 25%, anal pain 87.5%, anal tumor 75%, and fever 25%. Among the patients, 37.5% presented with melanoma and 62.5% lymphoma. Regarding patients with lymphoma, 60% had plasmablastic lymphoma and 40% non-Hodgkin's lymphoma. The diagnostic time was 4 months on average (1-8 months) and 25% of the patients had been previously misdiagnosed with hemorrhoidal disease. Conclusion: Non-epidermoid anal neoplasm cases are infrequent and its accurate diagnosis can take months, therefore, changing prognosis.