Deep brain stimulation of the orbitofrontal cortex reduces perseverative behavior induced by quinpirole in rats
Introduction: Different rodent models of obsessive-compulsive disorder (OCD) have been used with the purpose for understanding this mental disease; in a previous article, we described quinpirole (QP) as a dopaminergic inductor of perseverative behavior. Objective: The objective of this study was to evaluate the decrease of QP-induced perseverative behavior observed in an open field after unilateral deep brain stimulation-low frequency (DBS-LF) into the orbitofrontal cortex (OFC) in Wistar rats. Materials and Methods: A total of 40 adult male Wistar rats were divided into three groups, each group underwent pharmacological treatment: sodium chloride (NaCl), QP, and clomipramine (CMP), these groups were not implanted with an electrode. An additional group was implanted into OFC Sham (SH), and after behavior evaluation, unilateral DBS-LF (6 Hz) was applied during night time for 5 min each side; first left side and after right side. Results: Distance traveled significantly decreased in the 5 min observed between QP and NaCl (p = 0.016), and a significant difference was found between NaCl and SH (p = 0.020). There was no significant difference between NaCl and CMP (p = 0.582) or NaCl and DBS-LF (p = 0.829). No significant difference between DBS left side and right side was found (p = 1.00). Conclusions: Unilateral DBS of the OFC prevents perseverative behavior in an open field, induced by QP.
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Sociedad Médica del Hospital General de México A.C.
2019
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oai:scielo:S2524-177X20190001000152021-09-01Deep brain stimulation of the orbitofrontal cortex reduces perseverative behavior induced by quinpirole in ratsFlores-Vargas,AbrahamCampos-García-Rojas,CuauhtémocJiménez-Ponce,Fiacro Deep brain stimulation Quinpirole Orbitofrontal cortex Perseverative behavior Introduction: Different rodent models of obsessive-compulsive disorder (OCD) have been used with the purpose for understanding this mental disease; in a previous article, we described quinpirole (QP) as a dopaminergic inductor of perseverative behavior. Objective: The objective of this study was to evaluate the decrease of QP-induced perseverative behavior observed in an open field after unilateral deep brain stimulation-low frequency (DBS-LF) into the orbitofrontal cortex (OFC) in Wistar rats. Materials and Methods: A total of 40 adult male Wistar rats were divided into three groups, each group underwent pharmacological treatment: sodium chloride (NaCl), QP, and clomipramine (CMP), these groups were not implanted with an electrode. An additional group was implanted into OFC Sham (SH), and after behavior evaluation, unilateral DBS-LF (6 Hz) was applied during night time for 5 min each side; first left side and after right side. Results: Distance traveled significantly decreased in the 5 min observed between QP and NaCl (p = 0.016), and a significant difference was found between NaCl and SH (p = 0.020). There was no significant difference between NaCl and CMP (p = 0.582) or NaCl and DBS-LF (p = 0.829). No significant difference between DBS left side and right side was found (p = 1.00). Conclusions: Unilateral DBS of the OFC prevents perseverative behavior in an open field, induced by QP.info:eu-repo/semantics/openAccessSociedad Médica del Hospital General de México A.C.Revista médica del Hospital General de México v.82 n.1 20192019-03-01info:eu-repo/semantics/articletext/htmlhttp://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S2524-177X2019000100015en10.24875/hgmx.m19000008 |
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Flores-Vargas,Abraham Campos-García-Rojas,Cuauhtémoc Jiménez-Ponce,Fiacro |
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Flores-Vargas,Abraham Campos-García-Rojas,Cuauhtémoc Jiménez-Ponce,Fiacro Deep brain stimulation of the orbitofrontal cortex reduces perseverative behavior induced by quinpirole in rats |
author_facet |
Flores-Vargas,Abraham Campos-García-Rojas,Cuauhtémoc Jiménez-Ponce,Fiacro |
author_sort |
Flores-Vargas,Abraham |
title |
Deep brain stimulation of the orbitofrontal cortex reduces perseverative behavior induced by quinpirole in rats |
title_short |
Deep brain stimulation of the orbitofrontal cortex reduces perseverative behavior induced by quinpirole in rats |
title_full |
Deep brain stimulation of the orbitofrontal cortex reduces perseverative behavior induced by quinpirole in rats |
title_fullStr |
Deep brain stimulation of the orbitofrontal cortex reduces perseverative behavior induced by quinpirole in rats |
title_full_unstemmed |
Deep brain stimulation of the orbitofrontal cortex reduces perseverative behavior induced by quinpirole in rats |
title_sort |
deep brain stimulation of the orbitofrontal cortex reduces perseverative behavior induced by quinpirole in rats |
description |
Introduction: Different rodent models of obsessive-compulsive disorder (OCD) have been used with the purpose for understanding this mental disease; in a previous article, we described quinpirole (QP) as a dopaminergic inductor of perseverative behavior. Objective: The objective of this study was to evaluate the decrease of QP-induced perseverative behavior observed in an open field after unilateral deep brain stimulation-low frequency (DBS-LF) into the orbitofrontal cortex (OFC) in Wistar rats. Materials and Methods: A total of 40 adult male Wistar rats were divided into three groups, each group underwent pharmacological treatment: sodium chloride (NaCl), QP, and clomipramine (CMP), these groups were not implanted with an electrode. An additional group was implanted into OFC Sham (SH), and after behavior evaluation, unilateral DBS-LF (6 Hz) was applied during night time for 5 min each side; first left side and after right side. Results: Distance traveled significantly decreased in the 5 min observed between QP and NaCl (p = 0.016), and a significant difference was found between NaCl and SH (p = 0.020). There was no significant difference between NaCl and CMP (p = 0.582) or NaCl and DBS-LF (p = 0.829). No significant difference between DBS left side and right side was found (p = 1.00). Conclusions: Unilateral DBS of the OFC prevents perseverative behavior in an open field, induced by QP. |
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Sociedad Médica del Hospital General de México A.C. |
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2019 |
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http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S2524-177X2019000100015 |
work_keys_str_mv |
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