Active surveillance in papillary thyroid carcinoma: not easily accepted but possible in Latin America
ABSTRACT Objectives To determine the percentage of patients with papillary thyroid carcinoma (PTC) who accepted active surveillance as an alternative to surgery in our clinical practice and to describe the clinical characteristics and outcomes of patients with Bethesda category V and VI thyroid nodules who chose active surveillance. Subjects and methods We included 136 PTC patients from the Hospital de Clínicas, University of Buenos Aires without (i) US extrathyroidal extension, (ii) tumors adjacent to the recurrent laryngeal nerve or trachea, and/or (iii) US regional lymph-node metastasis or clinical distant metastasis. PTC progression was defined as the presence of i) a tumor larger than ≥ 3 mm, ii) novel appearance of lymph-node metastasis, and iii) serum thyroglobulin doubling time in less than one year. For patients with these features, surgery was recommended. Results Only 34 (25%) of 136 patients eligible for active surveillance accepted this approach, and around 10% of those who accepted abandoned it due to anxiety. The frequency of patients with tumor enlargement was 17% after a median of 4.6 years of follow-up without any evidence of nodal or distant metastases. Ten patients who underwent surgical treatment after a median time of 4 years of active surveillance (AS) had no evidence of disease after a median of 3.8 years of follow-up after surgery. Conclusion Although not easily accepted in our cohort of patients, AS would be safe and easily applicable in experienced centers.
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Sociedade Brasileira de Endocrinologia e Metabologia
2019
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oai:scielo:S2359-399720190008004622019-10-08Active surveillance in papillary thyroid carcinoma: not easily accepted but possible in Latin AmericaSmulever,AnabellaPitoia,Fabián Thyroid cancer observation active surveillance low-risk ABSTRACT Objectives To determine the percentage of patients with papillary thyroid carcinoma (PTC) who accepted active surveillance as an alternative to surgery in our clinical practice and to describe the clinical characteristics and outcomes of patients with Bethesda category V and VI thyroid nodules who chose active surveillance. Subjects and methods We included 136 PTC patients from the Hospital de Clínicas, University of Buenos Aires without (i) US extrathyroidal extension, (ii) tumors adjacent to the recurrent laryngeal nerve or trachea, and/or (iii) US regional lymph-node metastasis or clinical distant metastasis. PTC progression was defined as the presence of i) a tumor larger than ≥ 3 mm, ii) novel appearance of lymph-node metastasis, and iii) serum thyroglobulin doubling time in less than one year. For patients with these features, surgery was recommended. Results Only 34 (25%) of 136 patients eligible for active surveillance accepted this approach, and around 10% of those who accepted abandoned it due to anxiety. The frequency of patients with tumor enlargement was 17% after a median of 4.6 years of follow-up without any evidence of nodal or distant metastases. Ten patients who underwent surgical treatment after a median time of 4 years of active surveillance (AS) had no evidence of disease after a median of 3.8 years of follow-up after surgery. Conclusion Although not easily accepted in our cohort of patients, AS would be safe and easily applicable in experienced centers.info:eu-repo/semantics/openAccessSociedade Brasileira de Endocrinologia e MetabologiaArchives of Endocrinology and Metabolism v.63 n.5 20192019-10-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972019000800462en10.20945/2359-3997000000168 |
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Smulever,Anabella Pitoia,Fabián |
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Smulever,Anabella Pitoia,Fabián Active surveillance in papillary thyroid carcinoma: not easily accepted but possible in Latin America |
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Smulever,Anabella Pitoia,Fabián |
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Smulever,Anabella |
title |
Active surveillance in papillary thyroid carcinoma: not easily accepted but possible in Latin America |
title_short |
Active surveillance in papillary thyroid carcinoma: not easily accepted but possible in Latin America |
title_full |
Active surveillance in papillary thyroid carcinoma: not easily accepted but possible in Latin America |
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Active surveillance in papillary thyroid carcinoma: not easily accepted but possible in Latin America |
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Active surveillance in papillary thyroid carcinoma: not easily accepted but possible in Latin America |
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active surveillance in papillary thyroid carcinoma: not easily accepted but possible in latin america |
description |
ABSTRACT Objectives To determine the percentage of patients with papillary thyroid carcinoma (PTC) who accepted active surveillance as an alternative to surgery in our clinical practice and to describe the clinical characteristics and outcomes of patients with Bethesda category V and VI thyroid nodules who chose active surveillance. Subjects and methods We included 136 PTC patients from the Hospital de Clínicas, University of Buenos Aires without (i) US extrathyroidal extension, (ii) tumors adjacent to the recurrent laryngeal nerve or trachea, and/or (iii) US regional lymph-node metastasis or clinical distant metastasis. PTC progression was defined as the presence of i) a tumor larger than ≥ 3 mm, ii) novel appearance of lymph-node metastasis, and iii) serum thyroglobulin doubling time in less than one year. For patients with these features, surgery was recommended. Results Only 34 (25%) of 136 patients eligible for active surveillance accepted this approach, and around 10% of those who accepted abandoned it due to anxiety. The frequency of patients with tumor enlargement was 17% after a median of 4.6 years of follow-up without any evidence of nodal or distant metastases. Ten patients who underwent surgical treatment after a median time of 4 years of active surveillance (AS) had no evidence of disease after a median of 3.8 years of follow-up after surgery. Conclusion Although not easily accepted in our cohort of patients, AS would be safe and easily applicable in experienced centers. |
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Sociedade Brasileira de Endocrinologia e Metabologia |
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2019 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972019000800462 |
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AT smuleveranabella activesurveillanceinpapillarythyroidcarcinomanoteasilyacceptedbutpossibleinlatinamerica AT pitoiafabian activesurveillanceinpapillarythyroidcarcinomanoteasilyacceptedbutpossibleinlatinamerica |
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