Nonthyroidal illnesses syndrome in full-term newborns with sepsis
ABSTRACT Objective To assess hormonal changes in nonthyroidal illness syndrome (NTIS) in full-term newborns (NT) with sepsis. Materials and methods We included 28 NT with sepsis divided into 2 groups according to the time of normalization of serum and clinical indicators of infection: group A(A), 16 NT with improvement in up to 8 days; and group B(B), 12 NT improvement after 8 days. Among the 28 NT, 15 NT progressed to septic shock, with 5 NT group A and 10 NT in group B. NT were excluded when they showed severe sepsis and asphyxia, and congenital malformations, as well as those whose mothers had thyroid disease and IUGR. Results 17 NT (60.7%) presented NTIS. Low T3 was observed in NTIS in 10 NT (58.8%), and low T4 and T3 in 5 NT (29.5%), all of them with septic shock. Two NT showed mixed changes (11.7%). After sepsis was cured, there was no hormonal change, except in 3 NT. Administration of dopamine, furosemide, and corticosteroids did not affect the results. Conclusions This study indicates that nonthyroidal illness syndrome may be transiently present during sepsis in full-term newborns, especially in cases of prolonged sepsis. Low T3 can occur without changes in reverse T3 (different from adults), and low T4 and T3 occur mainly in patients with septic shock. Arch Endocrinol Metab. 2015;59(6):528-34
Main Authors: | Silva,Maria Helena Baptista Nunes da, Araujo,Maria Cristina Korbage de, Diniz,Edna Maria de Albuquerque, Ceccon,Maria Esther Jurfest Rivero, Carvalho,Werther Brunow de |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Sociedade Brasileira de Endocrinologia e Metabologia
2015
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972015000600528 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Thyroid abnormalities in term infants with fungal sepsis
by: Silva,Maria Helena Baptista Nunes da, et al.
Published: (2016) -
Nonthyroidal illness syndrome in patients with subarachnoid hemorrhage due to intracranial aneurysm
by: Casulari,Luiz Augusto, et al.
Published: (2004) -
Monitoring the treatment of sepsis with vancomycin in term newborn infants
by: Machado,José Kleber Kobol, et al.
Published: (2001) -
Diagnostic methods in canine hypothyroidism and influence of nonthyroidal illness on thyroid hormones and thyroxine-binding proteins
by: Larsson, Mats 19086, et al.
Published: (1987) -
Necrotizing fasciitis in a newborn infant: a case report
by: Krebs,Vera Lúcia Jornada, et al.
Published: (2001)