Thyroid hormone resistance in two patients with papillary thyroid microcarcinoma and their BRAFV600E mutation status
Resistance to thyroid hormone (RTH) is a rare autosomal dominant hereditary disorder. Here in, we report two patients with RTH in whom differentiated thyroid cancer was diagnosed. Two patients were admitted to our clinic and their laboratory results were elevated thyroid hormone levels with unsuppressed TSH. We considered this situation thyroid hormone resistance in the light of laboratory and clinical datas. Thyroid nodule was palpated on physical examination. Thyroid ultrasonography showed multiple nodules in both lobes. Total thyroidectomy was performed. The pathological findings were consistent with papillary thyroid microcarcinoma. BRAFV600E mutation analysis results were negative. RTH is very rare and might be overlooked. There is no consensus on how to overcome the persistently high TSH in patients with RTH and differentiated thyroid cancer (DTC). Further studies are needed to explain the relationship between RTH and DTC which might be helpful for the treatment of these patients.
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Sociedade Brasileira de Endocrinologia e Metabologia
2015
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oai:scielo:S2359-399720150004003642015-08-27Thyroid hormone resistance in two patients with papillary thyroid microcarcinoma and their BRAFV600E mutation statusKarakose,MeliaCaliskan,MustafaArslan,Muyesser SaykiCakal,ErmanYesilyurt,AhmetDelibasi,TuncayResistance to thyroid hormone (RTH) is a rare autosomal dominant hereditary disorder. Here in, we report two patients with RTH in whom differentiated thyroid cancer was diagnosed. Two patients were admitted to our clinic and their laboratory results were elevated thyroid hormone levels with unsuppressed TSH. We considered this situation thyroid hormone resistance in the light of laboratory and clinical datas. Thyroid nodule was palpated on physical examination. Thyroid ultrasonography showed multiple nodules in both lobes. Total thyroidectomy was performed. The pathological findings were consistent with papillary thyroid microcarcinoma. BRAFV600E mutation analysis results were negative. RTH is very rare and might be overlooked. There is no consensus on how to overcome the persistently high TSH in patients with RTH and differentiated thyroid cancer (DTC). Further studies are needed to explain the relationship between RTH and DTC which might be helpful for the treatment of these patients.info:eu-repo/semantics/openAccessSociedade Brasileira de Endocrinologia e MetabologiaArchives of Endocrinology and Metabolism v.59 n.4 20152015-08-01info:eu-repo/semantics/reporttext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972015000400364en10.1590/2359-3997000000091 |
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Karakose,Melia Caliskan,Mustafa Arslan,Muyesser Sayki Cakal,Erman Yesilyurt,Ahmet Delibasi,Tuncay |
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Karakose,Melia Caliskan,Mustafa Arslan,Muyesser Sayki Cakal,Erman Yesilyurt,Ahmet Delibasi,Tuncay Thyroid hormone resistance in two patients with papillary thyroid microcarcinoma and their BRAFV600E mutation status |
author_facet |
Karakose,Melia Caliskan,Mustafa Arslan,Muyesser Sayki Cakal,Erman Yesilyurt,Ahmet Delibasi,Tuncay |
author_sort |
Karakose,Melia |
title |
Thyroid hormone resistance in two patients with papillary thyroid microcarcinoma and their BRAFV600E mutation status |
title_short |
Thyroid hormone resistance in two patients with papillary thyroid microcarcinoma and their BRAFV600E mutation status |
title_full |
Thyroid hormone resistance in two patients with papillary thyroid microcarcinoma and their BRAFV600E mutation status |
title_fullStr |
Thyroid hormone resistance in two patients with papillary thyroid microcarcinoma and their BRAFV600E mutation status |
title_full_unstemmed |
Thyroid hormone resistance in two patients with papillary thyroid microcarcinoma and their BRAFV600E mutation status |
title_sort |
thyroid hormone resistance in two patients with papillary thyroid microcarcinoma and their brafv600e mutation status |
description |
Resistance to thyroid hormone (RTH) is a rare autosomal dominant hereditary disorder. Here in, we report two patients with RTH in whom differentiated thyroid cancer was diagnosed. Two patients were admitted to our clinic and their laboratory results were elevated thyroid hormone levels with unsuppressed TSH. We considered this situation thyroid hormone resistance in the light of laboratory and clinical datas. Thyroid nodule was palpated on physical examination. Thyroid ultrasonography showed multiple nodules in both lobes. Total thyroidectomy was performed. The pathological findings were consistent with papillary thyroid microcarcinoma. BRAFV600E mutation analysis results were negative. RTH is very rare and might be overlooked. There is no consensus on how to overcome the persistently high TSH in patients with RTH and differentiated thyroid cancer (DTC). Further studies are needed to explain the relationship between RTH and DTC which might be helpful for the treatment of these patients. |
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Sociedade Brasileira de Endocrinologia e Metabologia |
publishDate |
2015 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972015000400364 |
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