Seasonal variation of haemoglobin A1c in a Portuguese adult population
Objective Haemoglobin A1c (Hb A1c) is routinely used for monitoring glycemic control in patients with diabetes. Hb A1c seasonal fluctuations can be directly related to different biological, geographical and cultural influences. Our purpose was to evaluate seasonal variation of Hb A1c in a hospital-based adult population over a period of 5 years.Materials and methods We analyzed retrospectively monthly Hb A1c mean values (DCCT, %) based on all the assays performed to adult patients at a tertiary care university Portuguese hospital between 2008-2012.Results We obtained 62,384 Hb A1c valid measurements, with a peak level found in January-February (7.1%), a trough in August-October (6.8%) and an average peak-to-trough amplitude value of 0.3%. This trend was observed in both genders and age subgroups evaluated.Conclusions There is a Hb A1c circannual seasonal pattern with peak levels occurring in winter months in this Portuguese population. This finding should be recognized in daily clinical practice to warrant better clinical and epidemiological interpretation of Hb A1c values. Arch Endocrinol Metab. 2015;59(3):231-5
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Sociedade Brasileira de Endocrinologia e Metabologia
2015
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oai:scielo:S2359-399720150003002312015-07-03Seasonal variation of haemoglobin A1c in a Portuguese adult populationPereira,Maria Teresa Rocha e PinhoLira,DomingosBacelar,ConceiçãoOliveira,José CarlosCarvalho,André Couto de Seasonal variation haemoglobin A1c blood glucose Objective Haemoglobin A1c (Hb A1c) is routinely used for monitoring glycemic control in patients with diabetes. Hb A1c seasonal fluctuations can be directly related to different biological, geographical and cultural influences. Our purpose was to evaluate seasonal variation of Hb A1c in a hospital-based adult population over a period of 5 years.Materials and methods We analyzed retrospectively monthly Hb A1c mean values (DCCT, %) based on all the assays performed to adult patients at a tertiary care university Portuguese hospital between 2008-2012.Results We obtained 62,384 Hb A1c valid measurements, with a peak level found in January-February (7.1%), a trough in August-October (6.8%) and an average peak-to-trough amplitude value of 0.3%. This trend was observed in both genders and age subgroups evaluated.Conclusions There is a Hb A1c circannual seasonal pattern with peak levels occurring in winter months in this Portuguese population. This finding should be recognized in daily clinical practice to warrant better clinical and epidemiological interpretation of Hb A1c values. Arch Endocrinol Metab. 2015;59(3):231-5info:eu-repo/semantics/openAccessSociedade Brasileira de Endocrinologia e MetabologiaArchives of Endocrinology and Metabolism v.59 n.3 20152015-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972015000300231en10.1590/2359-3997000000043 |
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Pereira,Maria Teresa Rocha e Pinho Lira,Domingos Bacelar,Conceição Oliveira,José Carlos Carvalho,André Couto de |
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Pereira,Maria Teresa Rocha e Pinho Lira,Domingos Bacelar,Conceição Oliveira,José Carlos Carvalho,André Couto de Seasonal variation of haemoglobin A1c in a Portuguese adult population |
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Pereira,Maria Teresa Rocha e Pinho Lira,Domingos Bacelar,Conceição Oliveira,José Carlos Carvalho,André Couto de |
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Pereira,Maria Teresa Rocha e Pinho |
title |
Seasonal variation of haemoglobin A1c in a Portuguese adult population |
title_short |
Seasonal variation of haemoglobin A1c in a Portuguese adult population |
title_full |
Seasonal variation of haemoglobin A1c in a Portuguese adult population |
title_fullStr |
Seasonal variation of haemoglobin A1c in a Portuguese adult population |
title_full_unstemmed |
Seasonal variation of haemoglobin A1c in a Portuguese adult population |
title_sort |
seasonal variation of haemoglobin a1c in a portuguese adult population |
description |
Objective Haemoglobin A1c (Hb A1c) is routinely used for monitoring glycemic control in patients with diabetes. Hb A1c seasonal fluctuations can be directly related to different biological, geographical and cultural influences. Our purpose was to evaluate seasonal variation of Hb A1c in a hospital-based adult population over a period of 5 years.Materials and methods We analyzed retrospectively monthly Hb A1c mean values (DCCT, %) based on all the assays performed to adult patients at a tertiary care university Portuguese hospital between 2008-2012.Results We obtained 62,384 Hb A1c valid measurements, with a peak level found in January-February (7.1%), a trough in August-October (6.8%) and an average peak-to-trough amplitude value of 0.3%. This trend was observed in both genders and age subgroups evaluated.Conclusions There is a Hb A1c circannual seasonal pattern with peak levels occurring in winter months in this Portuguese population. This finding should be recognized in daily clinical practice to warrant better clinical and epidemiological interpretation of Hb A1c values. Arch Endocrinol Metab. 2015;59(3):231-5 |
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Sociedade Brasileira de Endocrinologia e Metabologia |
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2015 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972015000300231 |
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