Refractory Hidradenitis Suppurativa: A Diagnosis to Consider

Refractory Hidradenitis Suppurativa: A Diagnosis to Consider

Abstract Hidradenitis suppurativa is a chronic inflammatory disease associated with multiple comorbidities, and its association with lymphoma has recently been a topic of debate. However, it is still controversial whether this risk can be attributed to the disease itself or whether it has any relationship with immunosuppressive treatment. Here, we describe the case of a patient with severe perianal hidradenitis suppurativa treated with methotrexate and infliximab, whose exacerbation with persistence of severe symptoms refractory to adequate treatment led to the diagnosis of diffuse large non-Hodgkin B-cell lymphoma. It was decided to perform a colostomy to improve perianal sepsis, and immunochemotherapy was proposed.

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Main Authors: Saraiva,Rita Ornelas, Saunders,Christopher, Santos,Margarida Varela dos, Carvalho,Diana, Loureiro,Rafaela, Ramos,Jaime
Format: Digital revista
Language:English
Published: Sociedade Portuguesa de Gastrenterologia 2024
Online Access:http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452024000100060
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spelling oai:scielo:S2341-454520240001000602024-03-25Refractory Hidradenitis Suppurativa: A Diagnosis to ConsiderSaraiva,Rita OrnelasSaunders,ChristopherSantos,Margarida Varela dosCarvalho,DianaLoureiro,RafaelaRamos,Jaime Hidradenitis suppurativa Lymphoma Lymphoproliferative disorder Methotrexate Infliximab Abstract Hidradenitis suppurativa is a chronic inflammatory disease associated with multiple comorbidities, and its association with lymphoma has recently been a topic of debate. However, it is still controversial whether this risk can be attributed to the disease itself or whether it has any relationship with immunosuppressive treatment. Here, we describe the case of a patient with severe perianal hidradenitis suppurativa treated with methotrexate and infliximab, whose exacerbation with persistence of severe symptoms refractory to adequate treatment led to the diagnosis of diffuse large non-Hodgkin B-cell lymphoma. It was decided to perform a colostomy to improve perianal sepsis, and immunochemotherapy was proposed.info:eu-repo/semantics/openAccessSociedade Portuguesa de GastrenterologiaGE-Portuguese Journal of Gastroenterology v.31 n.1 20242024-02-01info:eu-repo/semantics/reporttext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452024000100060en10.1159/000528432
institution SCIELO
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country Portugal
countrycode PT
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region Europa del Sur
libraryname SciELO
language English
format Digital
author Saraiva,Rita Ornelas
Saunders,Christopher
Santos,Margarida Varela dos
Carvalho,Diana
Loureiro,Rafaela
Ramos,Jaime
spellingShingle Saraiva,Rita Ornelas
Saunders,Christopher
Santos,Margarida Varela dos
Carvalho,Diana
Loureiro,Rafaela
Ramos,Jaime
Refractory Hidradenitis Suppurativa: A Diagnosis to Consider
author_facet Saraiva,Rita Ornelas
Saunders,Christopher
Santos,Margarida Varela dos
Carvalho,Diana
Loureiro,Rafaela
Ramos,Jaime
author_sort Saraiva,Rita Ornelas
title Refractory Hidradenitis Suppurativa: A Diagnosis to Consider
title_short Refractory Hidradenitis Suppurativa: A Diagnosis to Consider
title_full Refractory Hidradenitis Suppurativa: A Diagnosis to Consider
title_fullStr Refractory Hidradenitis Suppurativa: A Diagnosis to Consider
title_full_unstemmed Refractory Hidradenitis Suppurativa: A Diagnosis to Consider
title_sort refractory hidradenitis suppurativa: a diagnosis to consider
description Abstract Hidradenitis suppurativa is a chronic inflammatory disease associated with multiple comorbidities, and its association with lymphoma has recently been a topic of debate. However, it is still controversial whether this risk can be attributed to the disease itself or whether it has any relationship with immunosuppressive treatment. Here, we describe the case of a patient with severe perianal hidradenitis suppurativa treated with methotrexate and infliximab, whose exacerbation with persistence of severe symptoms refractory to adequate treatment led to the diagnosis of diffuse large non-Hodgkin B-cell lymphoma. It was decided to perform a colostomy to improve perianal sepsis, and immunochemotherapy was proposed.
publisher Sociedade Portuguesa de Gastrenterologia
publishDate 2024
url http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452024000100060
work_keys_str_mv AT saraivaritaornelas refractoryhidradenitissuppurativaadiagnosistoconsider
AT saunderschristopher refractoryhidradenitissuppurativaadiagnosistoconsider
AT santosmargaridavarelados refractoryhidradenitissuppurativaadiagnosistoconsider
AT carvalhodiana refractoryhidradenitissuppurativaadiagnosistoconsider
AT loureirorafaela refractoryhidradenitissuppurativaadiagnosistoconsider
AT ramosjaime refractoryhidradenitissuppurativaadiagnosistoconsider
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