The Impact of Donor Risk Index, Recipients’ and Operative Characteristics on Post Liver Transplant One-Year Graft Failure: A Cohort Analysis
Abstract Background and Aims: The donor risk index (DRI) quantifies donor-related characteristics potentially associated with increased risk of early graft failure. We aimed to assess the impact of the DRI, recipient and perioperative factors on post liver transplant (LT) outcomes. Methods: This was a single-center retrospective cohort study including all adult (≥18 years) patients who underwent LT from 01/2019 to 12/2019 at Curry Cabral Hospital, Lisbon, Portugal. Primary endpoint was 1-year graft failure post LT. Associations were studied with logistic regression. Results: A total of 131 cadaveric donor LT procedures were performed in 116 recipients. Recipients’ median (IQR) age was 57 (47-64) years and 101/131 (77.1%) were males. Cirrhosis was the underlying etiology in 95/131 (81.2%) transplants. Based on 8 predefined donors’ characteristics, median (IQR) DRI was 1.96 (1.67-2.16). Following adjustment for MELDNa score pre LT and SOFA score (adjusted odds ratio [aOR], 95% confidence interval [CI] =0.91 [0.56-1.47]) or lactate (aOR [95% CI] = 2.76 [0.71-10.7]) upon intensive care unit (ICU) admission post LT, DRI was not associated with 1-year graft failure. However, higher SOFA score (aOR [95% CI] = 1.20 [1.05-1.37]) or lactate (aOR [95% CI] = 1.27 [1.10-1.46]) upon ICU admission post LT were independently associated with higher odds of 1-year graft failure. Conclusions: In a recent cohort of patients who under-went LT, DRI, despite being high, was not associated with 1-year graft failure, but SOFA score or lactate upon ICU ad-mission post LT were.
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Digital revista |
| Language: | English |
| Published: |
Sociedade Portuguesa de Gastrenterologia
2023
|
| Online Access: | http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452023000400023 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| id |
oai:scielo:S2341-45452023000400023 |
|---|---|
| record_format |
ojs |
| spelling |
oai:scielo:S2341-454520230004000232024-01-17The Impact of Donor Risk Index, Recipients’ and Operative Characteristics on Post Liver Transplant One-Year Graft Failure: A Cohort AnalysisCardoso,Filipe S.Bagulho,LuisCoelho,João S.Lamelas,JorgeMateus,ÉliaMendes,MilenaGlória,HelenaRibeiro,VascoMega,RaquelPena,AnaMarques,Hugo P.Germano,NunoNolasco,FernandoPerdigoto,RuiMartins,Américo Organ donor Liver Transplantation Abstract Background and Aims: The donor risk index (DRI) quantifies donor-related characteristics potentially associated with increased risk of early graft failure. We aimed to assess the impact of the DRI, recipient and perioperative factors on post liver transplant (LT) outcomes. Methods: This was a single-center retrospective cohort study including all adult (≥18 years) patients who underwent LT from 01/2019 to 12/2019 at Curry Cabral Hospital, Lisbon, Portugal. Primary endpoint was 1-year graft failure post LT. Associations were studied with logistic regression. Results: A total of 131 cadaveric donor LT procedures were performed in 116 recipients. Recipients’ median (IQR) age was 57 (47-64) years and 101/131 (77.1%) were males. Cirrhosis was the underlying etiology in 95/131 (81.2%) transplants. Based on 8 predefined donors’ characteristics, median (IQR) DRI was 1.96 (1.67-2.16). Following adjustment for MELDNa score pre LT and SOFA score (adjusted odds ratio [aOR], 95% confidence interval [CI] =0.91 [0.56-1.47]) or lactate (aOR [95% CI] = 2.76 [0.71-10.7]) upon intensive care unit (ICU) admission post LT, DRI was not associated with 1-year graft failure. However, higher SOFA score (aOR [95% CI] = 1.20 [1.05-1.37]) or lactate (aOR [95% CI] = 1.27 [1.10-1.46]) upon ICU admission post LT were independently associated with higher odds of 1-year graft failure. Conclusions: In a recent cohort of patients who under-went LT, DRI, despite being high, was not associated with 1-year graft failure, but SOFA score or lactate upon ICU ad-mission post LT were.info:eu-repo/semantics/openAccessSociedade Portuguesa de GastrenterologiaGE-Portuguese Journal of Gastroenterology v.30 n.4 20232023-08-01info:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452023000400023en10.1159/000524421 |
| institution |
SCIELO |
| collection |
OJS |
| country |
Portugal |
| countrycode |
PT |
| component |
Revista |
| access |
En linea |
| databasecode |
rev-scielo-pt |
| tag |
revista |
| region |
Europa del Sur |
| libraryname |
SciELO |
| language |
English |
| format |
Digital |
| author |
Cardoso,Filipe S. Bagulho,Luis Coelho,João S. Lamelas,Jorge Mateus,Élia Mendes,Milena Glória,Helena Ribeiro,Vasco Mega,Raquel Pena,Ana Marques,Hugo P. Germano,Nuno Nolasco,Fernando Perdigoto,Rui Martins,Américo |
| spellingShingle |
Cardoso,Filipe S. Bagulho,Luis Coelho,João S. Lamelas,Jorge Mateus,Élia Mendes,Milena Glória,Helena Ribeiro,Vasco Mega,Raquel Pena,Ana Marques,Hugo P. Germano,Nuno Nolasco,Fernando Perdigoto,Rui Martins,Américo The Impact of Donor Risk Index, Recipients’ and Operative Characteristics on Post Liver Transplant One-Year Graft Failure: A Cohort Analysis |
| author_facet |
Cardoso,Filipe S. Bagulho,Luis Coelho,João S. Lamelas,Jorge Mateus,Élia Mendes,Milena Glória,Helena Ribeiro,Vasco Mega,Raquel Pena,Ana Marques,Hugo P. Germano,Nuno Nolasco,Fernando Perdigoto,Rui Martins,Américo |
| author_sort |
Cardoso,Filipe S. |
| title |
The Impact of Donor Risk Index, Recipients’ and Operative Characteristics on Post Liver Transplant One-Year Graft Failure: A Cohort Analysis |
| title_short |
The Impact of Donor Risk Index, Recipients’ and Operative Characteristics on Post Liver Transplant One-Year Graft Failure: A Cohort Analysis |
| title_full |
The Impact of Donor Risk Index, Recipients’ and Operative Characteristics on Post Liver Transplant One-Year Graft Failure: A Cohort Analysis |
| title_fullStr |
The Impact of Donor Risk Index, Recipients’ and Operative Characteristics on Post Liver Transplant One-Year Graft Failure: A Cohort Analysis |
| title_full_unstemmed |
The Impact of Donor Risk Index, Recipients’ and Operative Characteristics on Post Liver Transplant One-Year Graft Failure: A Cohort Analysis |
| title_sort |
impact of donor risk index, recipients’ and operative characteristics on post liver transplant one-year graft failure: a cohort analysis |
| description |
Abstract Background and Aims: The donor risk index (DRI) quantifies donor-related characteristics potentially associated with increased risk of early graft failure. We aimed to assess the impact of the DRI, recipient and perioperative factors on post liver transplant (LT) outcomes. Methods: This was a single-center retrospective cohort study including all adult (≥18 years) patients who underwent LT from 01/2019 to 12/2019 at Curry Cabral Hospital, Lisbon, Portugal. Primary endpoint was 1-year graft failure post LT. Associations were studied with logistic regression. Results: A total of 131 cadaveric donor LT procedures were performed in 116 recipients. Recipients’ median (IQR) age was 57 (47-64) years and 101/131 (77.1%) were males. Cirrhosis was the underlying etiology in 95/131 (81.2%) transplants. Based on 8 predefined donors’ characteristics, median (IQR) DRI was 1.96 (1.67-2.16). Following adjustment for MELDNa score pre LT and SOFA score (adjusted odds ratio [aOR], 95% confidence interval [CI] =0.91 [0.56-1.47]) or lactate (aOR [95% CI] = 2.76 [0.71-10.7]) upon intensive care unit (ICU) admission post LT, DRI was not associated with 1-year graft failure. However, higher SOFA score (aOR [95% CI] = 1.20 [1.05-1.37]) or lactate (aOR [95% CI] = 1.27 [1.10-1.46]) upon ICU admission post LT were independently associated with higher odds of 1-year graft failure. Conclusions: In a recent cohort of patients who under-went LT, DRI, despite being high, was not associated with 1-year graft failure, but SOFA score or lactate upon ICU ad-mission post LT were. |
| publisher |
Sociedade Portuguesa de Gastrenterologia |
| publishDate |
2023 |
| url |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452023000400023 |
| work_keys_str_mv |
AT cardosofilipes theimpactofdonorriskindexrecipientsandoperativecharacteristicsonpostlivertransplantoneyeargraftfailureacohortanalysis AT bagulholuis theimpactofdonorriskindexrecipientsandoperativecharacteristicsonpostlivertransplantoneyeargraftfailureacohortanalysis AT coelhojoaos theimpactofdonorriskindexrecipientsandoperativecharacteristicsonpostlivertransplantoneyeargraftfailureacohortanalysis AT lamelasjorge theimpactofdonorriskindexrecipientsandoperativecharacteristicsonpostlivertransplantoneyeargraftfailureacohortanalysis AT mateuselia theimpactofdonorriskindexrecipientsandoperativecharacteristicsonpostlivertransplantoneyeargraftfailureacohortanalysis AT mendesmilena theimpactofdonorriskindexrecipientsandoperativecharacteristicsonpostlivertransplantoneyeargraftfailureacohortanalysis AT gloriahelena theimpactofdonorriskindexrecipientsandoperativecharacteristicsonpostlivertransplantoneyeargraftfailureacohortanalysis AT ribeirovasco theimpactofdonorriskindexrecipientsandoperativecharacteristicsonpostlivertransplantoneyeargraftfailureacohortanalysis AT megaraquel theimpactofdonorriskindexrecipientsandoperativecharacteristicsonpostlivertransplantoneyeargraftfailureacohortanalysis AT penaana theimpactofdonorriskindexrecipientsandoperativecharacteristicsonpostlivertransplantoneyeargraftfailureacohortanalysis AT marqueshugop theimpactofdonorriskindexrecipientsandoperativecharacteristicsonpostlivertransplantoneyeargraftfailureacohortanalysis AT germanonuno theimpactofdonorriskindexrecipientsandoperativecharacteristicsonpostlivertransplantoneyeargraftfailureacohortanalysis AT nolascofernando theimpactofdonorriskindexrecipientsandoperativecharacteristicsonpostlivertransplantoneyeargraftfailureacohortanalysis AT perdigotorui theimpactofdonorriskindexrecipientsandoperativecharacteristicsonpostlivertransplantoneyeargraftfailureacohortanalysis AT martinsamerico theimpactofdonorriskindexrecipientsandoperativecharacteristicsonpostlivertransplantoneyeargraftfailureacohortanalysis AT cardosofilipes impactofdonorriskindexrecipientsandoperativecharacteristicsonpostlivertransplantoneyeargraftfailureacohortanalysis AT bagulholuis impactofdonorriskindexrecipientsandoperativecharacteristicsonpostlivertransplantoneyeargraftfailureacohortanalysis AT coelhojoaos impactofdonorriskindexrecipientsandoperativecharacteristicsonpostlivertransplantoneyeargraftfailureacohortanalysis AT lamelasjorge impactofdonorriskindexrecipientsandoperativecharacteristicsonpostlivertransplantoneyeargraftfailureacohortanalysis AT mateuselia impactofdonorriskindexrecipientsandoperativecharacteristicsonpostlivertransplantoneyeargraftfailureacohortanalysis AT mendesmilena impactofdonorriskindexrecipientsandoperativecharacteristicsonpostlivertransplantoneyeargraftfailureacohortanalysis AT gloriahelena impactofdonorriskindexrecipientsandoperativecharacteristicsonpostlivertransplantoneyeargraftfailureacohortanalysis AT ribeirovasco impactofdonorriskindexrecipientsandoperativecharacteristicsonpostlivertransplantoneyeargraftfailureacohortanalysis AT megaraquel impactofdonorriskindexrecipientsandoperativecharacteristicsonpostlivertransplantoneyeargraftfailureacohortanalysis AT penaana impactofdonorriskindexrecipientsandoperativecharacteristicsonpostlivertransplantoneyeargraftfailureacohortanalysis AT marqueshugop impactofdonorriskindexrecipientsandoperativecharacteristicsonpostlivertransplantoneyeargraftfailureacohortanalysis AT germanonuno impactofdonorriskindexrecipientsandoperativecharacteristicsonpostlivertransplantoneyeargraftfailureacohortanalysis AT nolascofernando impactofdonorriskindexrecipientsandoperativecharacteristicsonpostlivertransplantoneyeargraftfailureacohortanalysis AT perdigotorui impactofdonorriskindexrecipientsandoperativecharacteristicsonpostlivertransplantoneyeargraftfailureacohortanalysis AT martinsamerico impactofdonorriskindexrecipientsandoperativecharacteristicsonpostlivertransplantoneyeargraftfailureacohortanalysis |
| _version_ |
1792505015387029504 |