Acute Liver Failure due to Trazodone and Diazepam

Acute Liver Failure due to Trazodone and Diazepam

Most antidepressant agents have the potential to cause liver injury, even at therapeutic doses. Nevertheless, drug-induced liver injury (DILI) from antidepressant agents is a rare event. There is no way to prevent idiopathic DILI, but the severity of the reaction may be minimized with prompt recognition and early withdrawal of the agent. We describe a rare case of a 63-year-old man presenting with acute liver failure after 3 months of trazodone and diazepam administration at normal therapeutic doses, requiring liver transplantation. This report should increase physicians’ awareness of this complication and call attention to the regular monitoring of liver tests in patients taking trazodone, in order to prevent life-threatening complications.

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Bibliographic Details
Main Authors: Carvalhana,Sofia, Oliveira,Ana, Ferreira,Pedro, Resende,Margarida, Perdigoto,Rui, Barroso,Eduardo
Format: Digital revista
Language:English
Published: Sociedade Portuguesa de Gastrenterologia 2017
Online Access:http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452017000100007
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spelling oai:scielo:S2341-454520170001000072017-09-19Acute Liver Failure due to Trazodone and DiazepamCarvalhana,SofiaOliveira,AnaFerreira,PedroResende,MargaridaPerdigoto,RuiBarroso,Eduardo Antidepressive agents Diazepam Liver failure, acute/chemically induced Trazodone Most antidepressant agents have the potential to cause liver injury, even at therapeutic doses. Nevertheless, drug-induced liver injury (DILI) from antidepressant agents is a rare event. There is no way to prevent idiopathic DILI, but the severity of the reaction may be minimized with prompt recognition and early withdrawal of the agent. We describe a rare case of a 63-year-old man presenting with acute liver failure after 3 months of trazodone and diazepam administration at normal therapeutic doses, requiring liver transplantation. This report should increase physicians’ awareness of this complication and call attention to the regular monitoring of liver tests in patients taking trazodone, in order to prevent life-threatening complications.info:eu-repo/semantics/openAccessSociedade Portuguesa de GastrenterologiaGE-Portuguese Journal of Gastroenterology v.24 n.1 20172017-02-01info:eu-repo/semantics/reporttext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452017000100007en10.1159/000450878
institution SCIELO
collection OJS
country Portugal
countrycode PT
component Revista
access En linea
databasecode rev-scielo-pt
tag revista
region Europa del Sur
libraryname SciELO
language English
format Digital
author Carvalhana,Sofia
Oliveira,Ana
Ferreira,Pedro
Resende,Margarida
Perdigoto,Rui
Barroso,Eduardo
spellingShingle Carvalhana,Sofia
Oliveira,Ana
Ferreira,Pedro
Resende,Margarida
Perdigoto,Rui
Barroso,Eduardo
Acute Liver Failure due to Trazodone and Diazepam
author_facet Carvalhana,Sofia
Oliveira,Ana
Ferreira,Pedro
Resende,Margarida
Perdigoto,Rui
Barroso,Eduardo
author_sort Carvalhana,Sofia
title Acute Liver Failure due to Trazodone and Diazepam
title_short Acute Liver Failure due to Trazodone and Diazepam
title_full Acute Liver Failure due to Trazodone and Diazepam
title_fullStr Acute Liver Failure due to Trazodone and Diazepam
title_full_unstemmed Acute Liver Failure due to Trazodone and Diazepam
title_sort acute liver failure due to trazodone and diazepam
description Most antidepressant agents have the potential to cause liver injury, even at therapeutic doses. Nevertheless, drug-induced liver injury (DILI) from antidepressant agents is a rare event. There is no way to prevent idiopathic DILI, but the severity of the reaction may be minimized with prompt recognition and early withdrawal of the agent. We describe a rare case of a 63-year-old man presenting with acute liver failure after 3 months of trazodone and diazepam administration at normal therapeutic doses, requiring liver transplantation. This report should increase physicians’ awareness of this complication and call attention to the regular monitoring of liver tests in patients taking trazodone, in order to prevent life-threatening complications.
publisher Sociedade Portuguesa de Gastrenterologia
publishDate 2017
url http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452017000100007
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AT oliveiraana acuteliverfailureduetotrazodoneanddiazepam
AT ferreirapedro acuteliverfailureduetotrazodoneanddiazepam
AT resendemargarida acuteliverfailureduetotrazodoneanddiazepam
AT perdigotorui acuteliverfailureduetotrazodoneanddiazepam
AT barrosoeduardo acuteliverfailureduetotrazodoneanddiazepam
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