A review of experimental models in colorectal carcinogenesis

A review of experimental models in colorectal carcinogenesis

ABSTRACT Colorectal cancer is the leading cause of malignancy of the gastrointestinal tract. A better understanding of the molecular and cellular changes that lead to the disease is necessary to develop early diagnosis and optimal treatment modalities. Rodent models are rapid, reproducible and exhibit an adenoma-carcinoma sequence similar to that found in humans. The objective of this manuscript is to review the most common chemical carcinogens used to induce experimental tumors and the usual methods of evaluation.

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Main Authors: Machado,Vanessa Foresto, Feitosa,Marley Ribeiro, Rocha,Jose Joaquim Ribeiro da, Féres,Omar
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Coloproctologia 2016
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632016000100053
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spelling oai:scielo:S2237-936320160001000532016-04-25A review of experimental models in colorectal carcinogenesisMachado,Vanessa ForestoFeitosa,Marley RibeiroRocha,Jose Joaquim Ribeiro daFéres,Omar Animal models Colorectal neoplasms Diagnosis ABSTRACT Colorectal cancer is the leading cause of malignancy of the gastrointestinal tract. A better understanding of the molecular and cellular changes that lead to the disease is necessary to develop early diagnosis and optimal treatment modalities. Rodent models are rapid, reproducible and exhibit an adenoma-carcinoma sequence similar to that found in humans. The objective of this manuscript is to review the most common chemical carcinogens used to induce experimental tumors and the usual methods of evaluation.info:eu-repo/semantics/openAccessSociedade Brasileira de ColoproctologiaJournal of Coloproctology (Rio de Janeiro) v.36 n.1 20162016-03-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632016000100053en10.1016/j.jcol.2015.09.001
institution SCIELO
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country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Machado,Vanessa Foresto
Feitosa,Marley Ribeiro
Rocha,Jose Joaquim Ribeiro da
Féres,Omar
spellingShingle Machado,Vanessa Foresto
Feitosa,Marley Ribeiro
Rocha,Jose Joaquim Ribeiro da
Féres,Omar
A review of experimental models in colorectal carcinogenesis
author_facet Machado,Vanessa Foresto
Feitosa,Marley Ribeiro
Rocha,Jose Joaquim Ribeiro da
Féres,Omar
author_sort Machado,Vanessa Foresto
title A review of experimental models in colorectal carcinogenesis
title_short A review of experimental models in colorectal carcinogenesis
title_full A review of experimental models in colorectal carcinogenesis
title_fullStr A review of experimental models in colorectal carcinogenesis
title_full_unstemmed A review of experimental models in colorectal carcinogenesis
title_sort review of experimental models in colorectal carcinogenesis
description ABSTRACT Colorectal cancer is the leading cause of malignancy of the gastrointestinal tract. A better understanding of the molecular and cellular changes that lead to the disease is necessary to develop early diagnosis and optimal treatment modalities. Rodent models are rapid, reproducible and exhibit an adenoma-carcinoma sequence similar to that found in humans. The objective of this manuscript is to review the most common chemical carcinogens used to induce experimental tumors and the usual methods of evaluation.
publisher Sociedade Brasileira de Coloproctologia
publishDate 2016
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632016000100053
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AT rochajosejoaquimribeiroda areviewofexperimentalmodelsincolorectalcarcinogenesis
AT feresomar areviewofexperimentalmodelsincolorectalcarcinogenesis
AT machadovanessaforesto reviewofexperimentalmodelsincolorectalcarcinogenesis
AT feitosamarleyribeiro reviewofexperimentalmodelsincolorectalcarcinogenesis
AT rochajosejoaquimribeiroda reviewofexperimentalmodelsincolorectalcarcinogenesis
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