Clinical-pathological and p53 protein expression study in dysplasia associated with ulcerative colitis,
Background: The association between ulcerative colitis and adenocarcinoma determined strategies for patient follow-up and early detection of dysplastic and neoplastic lesions. Aims: To analyze the incidence of dysplasia in patients with ulcerative colitis, comparing clinical data of patients with and without dysplasia and check immunohistochemical expression of p53 protein in dysplasias. Materials and methods: We analyzed biopsy samples and clinical data of 124 patients with ulcerative colitis at Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil. Results: Dysplasia incidence was low (9.67%) and all cases with low-grade dysplasia. Patients clinical data comparison with and without dysplasia did not show significant statistical differences with regard to the race, age at the start of the disease, age at last biopsy, duration and anatomic extent of ulcerative colitis. Significant difference was found between males and females with predominance of males (58.34%) for dysplasia. Seventeenth biopsy samples of 12 patients with dysplasia, 5 (29.4%) were p53 positive. Conclusions: From these results it is concluded that the incidence of dysplasia was low, higher in males and there was positivity of p53 protein in dysplasia.
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Sociedade Brasileira de Coloproctologia
2014
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oai:scielo:S2237-936320140003001362015-08-25Clinical-pathological and p53 protein expression study in dysplasia associated with ulcerative colitis,Baldin Júnior,AntônioTelles,José Ederaldo QueirozBonardi,Renato de AraújoAmarante,Heda Maria Barska dos SantosBaldin,Rosimeri Kuhl Svoboda Ulcerative rectocolitis Dysplasia Protein p53 Background: The association between ulcerative colitis and adenocarcinoma determined strategies for patient follow-up and early detection of dysplastic and neoplastic lesions. Aims: To analyze the incidence of dysplasia in patients with ulcerative colitis, comparing clinical data of patients with and without dysplasia and check immunohistochemical expression of p53 protein in dysplasias. Materials and methods: We analyzed biopsy samples and clinical data of 124 patients with ulcerative colitis at Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil. Results: Dysplasia incidence was low (9.67%) and all cases with low-grade dysplasia. Patients clinical data comparison with and without dysplasia did not show significant statistical differences with regard to the race, age at the start of the disease, age at last biopsy, duration and anatomic extent of ulcerative colitis. Significant difference was found between males and females with predominance of males (58.34%) for dysplasia. Seventeenth biopsy samples of 12 patients with dysplasia, 5 (29.4%) were p53 positive. Conclusions: From these results it is concluded that the incidence of dysplasia was low, higher in males and there was positivity of p53 protein in dysplasia. info:eu-repo/semantics/openAccessSociedade Brasileira de ColoproctologiaJournal of Coloproctology (Rio de Janeiro) v.34 n.3 20142014-09-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632014000300136en10.1016/j.jcol.2014.02.009 |
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Baldin Júnior,Antônio Telles,José Ederaldo Queiroz Bonardi,Renato de Araújo Amarante,Heda Maria Barska dos Santos Baldin,Rosimeri Kuhl Svoboda |
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Baldin Júnior,Antônio Telles,José Ederaldo Queiroz Bonardi,Renato de Araújo Amarante,Heda Maria Barska dos Santos Baldin,Rosimeri Kuhl Svoboda Clinical-pathological and p53 protein expression study in dysplasia associated with ulcerative colitis, |
| author_facet |
Baldin Júnior,Antônio Telles,José Ederaldo Queiroz Bonardi,Renato de Araújo Amarante,Heda Maria Barska dos Santos Baldin,Rosimeri Kuhl Svoboda |
| author_sort |
Baldin Júnior,Antônio |
| title |
Clinical-pathological and p53 protein expression study in dysplasia associated with ulcerative colitis, |
| title_short |
Clinical-pathological and p53 protein expression study in dysplasia associated with ulcerative colitis, |
| title_full |
Clinical-pathological and p53 protein expression study in dysplasia associated with ulcerative colitis, |
| title_fullStr |
Clinical-pathological and p53 protein expression study in dysplasia associated with ulcerative colitis, |
| title_full_unstemmed |
Clinical-pathological and p53 protein expression study in dysplasia associated with ulcerative colitis, |
| title_sort |
clinical-pathological and p53 protein expression study in dysplasia associated with ulcerative colitis, |
| description |
Background: The association between ulcerative colitis and adenocarcinoma determined strategies for patient follow-up and early detection of dysplastic and neoplastic lesions. Aims: To analyze the incidence of dysplasia in patients with ulcerative colitis, comparing clinical data of patients with and without dysplasia and check immunohistochemical expression of p53 protein in dysplasias. Materials and methods: We analyzed biopsy samples and clinical data of 124 patients with ulcerative colitis at Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil. Results: Dysplasia incidence was low (9.67%) and all cases with low-grade dysplasia. Patients clinical data comparison with and without dysplasia did not show significant statistical differences with regard to the race, age at the start of the disease, age at last biopsy, duration and anatomic extent of ulcerative colitis. Significant difference was found between males and females with predominance of males (58.34%) for dysplasia. Seventeenth biopsy samples of 12 patients with dysplasia, 5 (29.4%) were p53 positive. Conclusions: From these results it is concluded that the incidence of dysplasia was low, higher in males and there was positivity of p53 protein in dysplasia. |
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Sociedade Brasileira de Coloproctologia |
| publishDate |
2014 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632014000300136 |
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