Disseminated cryptococcosis and hemochromatosis: clues to diagnosis

Disseminated cryptococcosis and hemochromatosis: clues to diagnosis

ABSTRACT Hepatic cirrhosis, diabetes mellitus and iron overload can each independently predispose to cryptococcosis. Hereditary hemochromatosis leads to all three of these predispositions. This report is the case of a patient with chronic hepatitis B virus infection and cirrhosis, who had markedly elevated serum ferritin and 99% transferrin saturation, and developed a leukemoid reaction. Autopsy revealed disseminated cryptococcosis for which the leukemoid reaction was a clue and possible hereditary hemochromatosis of which elevated ferritin and transferrin saturation can be clues. Hereditary hemochromatosis is an important diagnosis clinicians should never miss because early treatment with phlebotomy can be life-saving. Disseminated cryptococcosis can be rapidly diagnosed with serum cryptococcal antigen test and is treatable.

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Main Authors: Nichols,Larry, Rowley,Lindsey, Lall,Ashley
Format: Digital revista
Language:English
Published: Hospital Universitário da Universidade de São Paulo 2020
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2236-19602020000300300
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spelling oai:scielo:S2236-196020200003003002020-11-09Disseminated cryptococcosis and hemochromatosis: clues to diagnosisNichols,LarryRowley,LindseyLall,Ashley Cryptococcosis Hemochromatosis Hepatitis Autopsy ABSTRACT Hepatic cirrhosis, diabetes mellitus and iron overload can each independently predispose to cryptococcosis. Hereditary hemochromatosis leads to all three of these predispositions. This report is the case of a patient with chronic hepatitis B virus infection and cirrhosis, who had markedly elevated serum ferritin and 99% transferrin saturation, and developed a leukemoid reaction. Autopsy revealed disseminated cryptococcosis for which the leukemoid reaction was a clue and possible hereditary hemochromatosis of which elevated ferritin and transferrin saturation can be clues. Hereditary hemochromatosis is an important diagnosis clinicians should never miss because early treatment with phlebotomy can be life-saving. Disseminated cryptococcosis can be rapidly diagnosed with serum cryptococcal antigen test and is treatable.info:eu-repo/semantics/openAccessHospital Universitário da Universidade de São PauloAutopsy and Case Reports v.10 n.3 20202020-01-01info:eu-repo/semantics/reporttext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2236-19602020000300300en10.4322/acr.2020.180
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Nichols,Larry
Rowley,Lindsey
Lall,Ashley
spellingShingle Nichols,Larry
Rowley,Lindsey
Lall,Ashley
Disseminated cryptococcosis and hemochromatosis: clues to diagnosis
author_facet Nichols,Larry
Rowley,Lindsey
Lall,Ashley
author_sort Nichols,Larry
title Disseminated cryptococcosis and hemochromatosis: clues to diagnosis
title_short Disseminated cryptococcosis and hemochromatosis: clues to diagnosis
title_full Disseminated cryptococcosis and hemochromatosis: clues to diagnosis
title_fullStr Disseminated cryptococcosis and hemochromatosis: clues to diagnosis
title_full_unstemmed Disseminated cryptococcosis and hemochromatosis: clues to diagnosis
title_sort disseminated cryptococcosis and hemochromatosis: clues to diagnosis
description ABSTRACT Hepatic cirrhosis, diabetes mellitus and iron overload can each independently predispose to cryptococcosis. Hereditary hemochromatosis leads to all three of these predispositions. This report is the case of a patient with chronic hepatitis B virus infection and cirrhosis, who had markedly elevated serum ferritin and 99% transferrin saturation, and developed a leukemoid reaction. Autopsy revealed disseminated cryptococcosis for which the leukemoid reaction was a clue and possible hereditary hemochromatosis of which elevated ferritin and transferrin saturation can be clues. Hereditary hemochromatosis is an important diagnosis clinicians should never miss because early treatment with phlebotomy can be life-saving. Disseminated cryptococcosis can be rapidly diagnosed with serum cryptococcal antigen test and is treatable.
publisher Hospital Universitário da Universidade de São Paulo
publishDate 2020
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2236-19602020000300300
work_keys_str_mv AT nicholslarry disseminatedcryptococcosisandhemochromatosiscluestodiagnosis
AT rowleylindsey disseminatedcryptococcosisandhemochromatosiscluestodiagnosis
AT lallashley disseminatedcryptococcosisandhemochromatosiscluestodiagnosis
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