KETOGENIC DIET AND EPILEPSY: A NARRATIVE REVIEW OF THE LITERATURE

KETOGENIC DIET AND EPILEPSY: A NARRATIVE REVIEW OF THE LITERATURE

ABSTRACT Several studies have already explored the role of ketone bodies on the physiological processes involved in the onset of seizures and ketogenic diet is a common treatment option in drug-resistant epilepsy either in children, adolescents or adults. This narrative review aims to summarize the available evidence on the possible mechanisms of action, and on the efficacy of the ketogenic diet and its variants on the treatment of epilepsy from infants to adults. Even though there is a robust biologic plausibility and either mechanistic studies and randomized controlled trials supporting ketogenic diet as a valid approach to reduce seizures in drug-resistant childhood epilepsy, the level of evidence is not as strong for the treatment of drug-resistant epilepsy in adults.

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Main Authors: D'Ascanio,Francesca, Ferreira,Inês, Jorge,Rui
Format: Digital revista
Language:English
Published: Associação Portuguesa de Nutrição 2021
Online Access:http://scielo.pt/scielo.php?script=sci_arttext&pid=S2183-59852021000400064
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spelling oai:scielo:S2183-598520210004000642022-03-29KETOGENIC DIET AND EPILEPSY: A NARRATIVE REVIEW OF THE LITERATURED'Ascanio,FrancescaFerreira,InêsJorge,Rui Epilepsy Ketone bodies Ketogenic diet Seizures ABSTRACT Several studies have already explored the role of ketone bodies on the physiological processes involved in the onset of seizures and ketogenic diet is a common treatment option in drug-resistant epilepsy either in children, adolescents or adults. This narrative review aims to summarize the available evidence on the possible mechanisms of action, and on the efficacy of the ketogenic diet and its variants on the treatment of epilepsy from infants to adults. Even though there is a robust biologic plausibility and either mechanistic studies and randomized controlled trials supporting ketogenic diet as a valid approach to reduce seizures in drug-resistant childhood epilepsy, the level of evidence is not as strong for the treatment of drug-resistant epilepsy in adults.info:eu-repo/semantics/openAccessAssociação Portuguesa de NutriçãoActa Portuguesa de Nutrição n.27 20212021-12-01info:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S2183-59852021000400064en10.21011/apn.2021.2711
institution SCIELO
collection OJS
country Portugal
countrycode PT
component Revista
access En linea
databasecode rev-scielo-pt
tag revista
region Europa del Sur
libraryname SciELO
language English
format Digital
author D'Ascanio,Francesca
Ferreira,Inês
Jorge,Rui
spellingShingle D'Ascanio,Francesca
Ferreira,Inês
Jorge,Rui
KETOGENIC DIET AND EPILEPSY: A NARRATIVE REVIEW OF THE LITERATURE
author_facet D'Ascanio,Francesca
Ferreira,Inês
Jorge,Rui
author_sort D'Ascanio,Francesca
title KETOGENIC DIET AND EPILEPSY: A NARRATIVE REVIEW OF THE LITERATURE
title_short KETOGENIC DIET AND EPILEPSY: A NARRATIVE REVIEW OF THE LITERATURE
title_full KETOGENIC DIET AND EPILEPSY: A NARRATIVE REVIEW OF THE LITERATURE
title_fullStr KETOGENIC DIET AND EPILEPSY: A NARRATIVE REVIEW OF THE LITERATURE
title_full_unstemmed KETOGENIC DIET AND EPILEPSY: A NARRATIVE REVIEW OF THE LITERATURE
title_sort ketogenic diet and epilepsy: a narrative review of the literature
description ABSTRACT Several studies have already explored the role of ketone bodies on the physiological processes involved in the onset of seizures and ketogenic diet is a common treatment option in drug-resistant epilepsy either in children, adolescents or adults. This narrative review aims to summarize the available evidence on the possible mechanisms of action, and on the efficacy of the ketogenic diet and its variants on the treatment of epilepsy from infants to adults. Even though there is a robust biologic plausibility and either mechanistic studies and randomized controlled trials supporting ketogenic diet as a valid approach to reduce seizures in drug-resistant childhood epilepsy, the level of evidence is not as strong for the treatment of drug-resistant epilepsy in adults.
publisher Associação Portuguesa de Nutrição
publishDate 2021
url http://scielo.pt/scielo.php?script=sci_arttext&pid=S2183-59852021000400064
work_keys_str_mv AT dascaniofrancesca ketogenicdietandepilepsyanarrativereviewoftheliterature
AT ferreiraines ketogenicdietandepilepsyanarrativereviewoftheliterature
AT jorgerui ketogenicdietandepilepsyanarrativereviewoftheliterature
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