Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular risk
Abstract Hypertriglyceridemia is associated with several metabolic diseases. The triglycerides (TG) disrupt the cholesterol reverse transport and contribute to increased levels of low-density lipoprotein (LDL). High-density lipoprotein (HDL) acts in cholesterol reverse transport as an anti-inflammatory and antioxidant. This study aims to investigate the role of hypertriglyceridemia in the functionality of HDL. Individuals were divided into 4 groups based on high or low HDL-c and triglycerides levels. Biochemical and anthropometric analysis were performed. This study demonstrated that triglycerides promote dysfunctions on HDL, increasing the cardiovascular risk. Blood pressure was higher in subjects with low HDL. Women presented higher levels of HDL-c and low percentage of fat mass. The highest levels of triglycerides were observed in older age. In addition, high levels of triglycerides were associated with higher total cholesterol and LDL-c levels, non-HDL-c, non-esterified fatty acids, and blood glucose, increasing in the ratio of non-HDL-c/HDL-c and ApoB/ApoA-I. The increase of triglycerides levels progressively impairs the antioxidant capacity of HDL, probably due to a higher occurrence of fatty acid peroxidation in individuals with hypertriglyceridemia. Patients with high HDL and low TG levels increased the Lag Time. Furthermore, a positive correlation was found between TG versus HDL particle size, variables that depend on age and anthropometric parameters.
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Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
2022
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oai:scielo:S1984-825020220001008822023-01-12Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular riskMeneses,Richard Rarison CavalcanteDamasceno,Nágila Raquel TeixeiraCartolano,Flávia De ContiVerde,Sara Maria Moreira LimaLira,Letícia GomesDantas,Mariana BritoViana,Glautemberg de AlmeidaSilva,Mateus Edson daSousa,Ederson Laurindo Holanda deMeneses,Gdayllon CavalcanteFerreira,Jamile MagalhãesSampaio,Tiago LimaQueiroz,Maria Goretti Rodrigues de Triglycerides Lipoproteins Apolipoprotein A-I Dyslipidemia Abstract Hypertriglyceridemia is associated with several metabolic diseases. The triglycerides (TG) disrupt the cholesterol reverse transport and contribute to increased levels of low-density lipoprotein (LDL). High-density lipoprotein (HDL) acts in cholesterol reverse transport as an anti-inflammatory and antioxidant. This study aims to investigate the role of hypertriglyceridemia in the functionality of HDL. Individuals were divided into 4 groups based on high or low HDL-c and triglycerides levels. Biochemical and anthropometric analysis were performed. This study demonstrated that triglycerides promote dysfunctions on HDL, increasing the cardiovascular risk. Blood pressure was higher in subjects with low HDL. Women presented higher levels of HDL-c and low percentage of fat mass. The highest levels of triglycerides were observed in older age. In addition, high levels of triglycerides were associated with higher total cholesterol and LDL-c levels, non-HDL-c, non-esterified fatty acids, and blood glucose, increasing in the ratio of non-HDL-c/HDL-c and ApoB/ApoA-I. The increase of triglycerides levels progressively impairs the antioxidant capacity of HDL, probably due to a higher occurrence of fatty acid peroxidation in individuals with hypertriglyceridemia. Patients with high HDL and low TG levels increased the Lag Time. Furthermore, a positive correlation was found between TG versus HDL particle size, variables that depend on age and anthropometric parameters.info:eu-repo/semantics/openAccessUniversidade de São Paulo, Faculdade de Ciências FarmacêuticasBrazilian Journal of Pharmaceutical Sciences v.58 20222022-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100882en10.1590/s2175-97902022e20488 |
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Meneses,Richard Rarison Cavalcante Damasceno,Nágila Raquel Teixeira Cartolano,Flávia De Conti Verde,Sara Maria Moreira Lima Lira,Letícia Gomes Dantas,Mariana Brito Viana,Glautemberg de Almeida Silva,Mateus Edson da Sousa,Ederson Laurindo Holanda de Meneses,Gdayllon Cavalcante Ferreira,Jamile Magalhães Sampaio,Tiago Lima Queiroz,Maria Goretti Rodrigues de |
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Meneses,Richard Rarison Cavalcante Damasceno,Nágila Raquel Teixeira Cartolano,Flávia De Conti Verde,Sara Maria Moreira Lima Lira,Letícia Gomes Dantas,Mariana Brito Viana,Glautemberg de Almeida Silva,Mateus Edson da Sousa,Ederson Laurindo Holanda de Meneses,Gdayllon Cavalcante Ferreira,Jamile Magalhães Sampaio,Tiago Lima Queiroz,Maria Goretti Rodrigues de Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular risk |
author_facet |
Meneses,Richard Rarison Cavalcante Damasceno,Nágila Raquel Teixeira Cartolano,Flávia De Conti Verde,Sara Maria Moreira Lima Lira,Letícia Gomes Dantas,Mariana Brito Viana,Glautemberg de Almeida Silva,Mateus Edson da Sousa,Ederson Laurindo Holanda de Meneses,Gdayllon Cavalcante Ferreira,Jamile Magalhães Sampaio,Tiago Lima Queiroz,Maria Goretti Rodrigues de |
author_sort |
Meneses,Richard Rarison Cavalcante |
title |
Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular risk |
title_short |
Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular risk |
title_full |
Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular risk |
title_fullStr |
Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular risk |
title_full_unstemmed |
Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular risk |
title_sort |
hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular risk |
description |
Abstract Hypertriglyceridemia is associated with several metabolic diseases. The triglycerides (TG) disrupt the cholesterol reverse transport and contribute to increased levels of low-density lipoprotein (LDL). High-density lipoprotein (HDL) acts in cholesterol reverse transport as an anti-inflammatory and antioxidant. This study aims to investigate the role of hypertriglyceridemia in the functionality of HDL. Individuals were divided into 4 groups based on high or low HDL-c and triglycerides levels. Biochemical and anthropometric analysis were performed. This study demonstrated that triglycerides promote dysfunctions on HDL, increasing the cardiovascular risk. Blood pressure was higher in subjects with low HDL. Women presented higher levels of HDL-c and low percentage of fat mass. The highest levels of triglycerides were observed in older age. In addition, high levels of triglycerides were associated with higher total cholesterol and LDL-c levels, non-HDL-c, non-esterified fatty acids, and blood glucose, increasing in the ratio of non-HDL-c/HDL-c and ApoB/ApoA-I. The increase of triglycerides levels progressively impairs the antioxidant capacity of HDL, probably due to a higher occurrence of fatty acid peroxidation in individuals with hypertriglyceridemia. Patients with high HDL and low TG levels increased the Lag Time. Furthermore, a positive correlation was found between TG versus HDL particle size, variables that depend on age and anthropometric parameters. |
publisher |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas |
publishDate |
2022 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100882 |
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