Efficacy and safety of fluticasone propionate nasal spray in treatment ofadenoidal hypertrophic snoring in children
Abstract This study investigatedthe efficacy and safety offluticasone propionate nasal spray in treatment of adenoidal hypertrophic snoring in children.Fifty-six children with adenoidal hypertrophic snoring were enrolled. According to adenoidal-nasopharyngeal ratio (ANR) in lateral nasal X-ray examination,the children were assigned in moderategroup (23 cases) and severegroup (33 cases).The fluticasone propionate nasal spray was used for all patientsfor 4 weeks.In 56 patients, after treatment, compared with before treatment, the snoring, sleep apneaand nasal obstruction scores in moderategroupand the nasal obstruction score in severegroupwere significantly decreased,respectively (P < 0.05).The decreases of snoring, sleep apnea, mouth breathing and nasal obstruction scores after treatment in moderate group were significantly higher than those in severe group, respectively (P <0.001).After treatment, in 18 patients with ateral nasal X-ray examination,the adenoid size was obviously reduced, and the nasopharynx airway was obviously enlarged. The meanANRdropped from 0.76±0.10 to 0.72±0.09(P <0.001).Duringtreatment, only 2 of 56 patients were reported with intranasal dryness and occasional epistaxis, which were self-healed without treatment.Fluticasone propionate nasal spray is effective and safe for treatment of children’s snoring caused by adenoidal hypertrophy.
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Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
2022
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oai:scielo:S1984-825020220001008472023-01-05Efficacy and safety of fluticasone propionate nasal spray in treatment ofadenoidal hypertrophic snoring in childrenDuan,HanzhongXia,LiLan,Qing Adenoidal hypertrophy Snoring Fluticasone propionate Children Abstract This study investigatedthe efficacy and safety offluticasone propionate nasal spray in treatment of adenoidal hypertrophic snoring in children.Fifty-six children with adenoidal hypertrophic snoring were enrolled. According to adenoidal-nasopharyngeal ratio (ANR) in lateral nasal X-ray examination,the children were assigned in moderategroup (23 cases) and severegroup (33 cases).The fluticasone propionate nasal spray was used for all patientsfor 4 weeks.In 56 patients, after treatment, compared with before treatment, the snoring, sleep apneaand nasal obstruction scores in moderategroupand the nasal obstruction score in severegroupwere significantly decreased,respectively (P < 0.05).The decreases of snoring, sleep apnea, mouth breathing and nasal obstruction scores after treatment in moderate group were significantly higher than those in severe group, respectively (P <0.001).After treatment, in 18 patients with ateral nasal X-ray examination,the adenoid size was obviously reduced, and the nasopharynx airway was obviously enlarged. The meanANRdropped from 0.76±0.10 to 0.72±0.09(P <0.001).Duringtreatment, only 2 of 56 patients were reported with intranasal dryness and occasional epistaxis, which were self-healed without treatment.Fluticasone propionate nasal spray is effective and safe for treatment of children’s snoring caused by adenoidal hypertrophy.info:eu-repo/semantics/openAccessUniversidade de São Paulo, Faculdade de Ciências FarmacêuticasBrazilian Journal of Pharmaceutical Sciences v.58 20222022-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100847en10.1590/s2175-97902022e21052 |
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Duan,Hanzhong Xia,Li Lan,Qing |
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Duan,Hanzhong Xia,Li Lan,Qing Efficacy and safety of fluticasone propionate nasal spray in treatment ofadenoidal hypertrophic snoring in children |
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Duan,Hanzhong Xia,Li Lan,Qing |
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Duan,Hanzhong |
title |
Efficacy and safety of fluticasone propionate nasal spray in treatment ofadenoidal hypertrophic snoring in children |
title_short |
Efficacy and safety of fluticasone propionate nasal spray in treatment ofadenoidal hypertrophic snoring in children |
title_full |
Efficacy and safety of fluticasone propionate nasal spray in treatment ofadenoidal hypertrophic snoring in children |
title_fullStr |
Efficacy and safety of fluticasone propionate nasal spray in treatment ofadenoidal hypertrophic snoring in children |
title_full_unstemmed |
Efficacy and safety of fluticasone propionate nasal spray in treatment ofadenoidal hypertrophic snoring in children |
title_sort |
efficacy and safety of fluticasone propionate nasal spray in treatment ofadenoidal hypertrophic snoring in children |
description |
Abstract This study investigatedthe efficacy and safety offluticasone propionate nasal spray in treatment of adenoidal hypertrophic snoring in children.Fifty-six children with adenoidal hypertrophic snoring were enrolled. According to adenoidal-nasopharyngeal ratio (ANR) in lateral nasal X-ray examination,the children were assigned in moderategroup (23 cases) and severegroup (33 cases).The fluticasone propionate nasal spray was used for all patientsfor 4 weeks.In 56 patients, after treatment, compared with before treatment, the snoring, sleep apneaand nasal obstruction scores in moderategroupand the nasal obstruction score in severegroupwere significantly decreased,respectively (P < 0.05).The decreases of snoring, sleep apnea, mouth breathing and nasal obstruction scores after treatment in moderate group were significantly higher than those in severe group, respectively (P <0.001).After treatment, in 18 patients with ateral nasal X-ray examination,the adenoid size was obviously reduced, and the nasopharynx airway was obviously enlarged. The meanANRdropped from 0.76±0.10 to 0.72±0.09(P <0.001).Duringtreatment, only 2 of 56 patients were reported with intranasal dryness and occasional epistaxis, which were self-healed without treatment.Fluticasone propionate nasal spray is effective and safe for treatment of children’s snoring caused by adenoidal hypertrophy. |
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Universidade de São Paulo, Faculdade de Ciências Farmacêuticas |
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2022 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100847 |
work_keys_str_mv |
AT duanhanzhong efficacyandsafetyoffluticasonepropionatenasalsprayintreatmentofadenoidalhypertrophicsnoringinchildren AT xiali efficacyandsafetyoffluticasonepropionatenasalsprayintreatmentofadenoidalhypertrophicsnoringinchildren AT lanqing efficacyandsafetyoffluticasonepropionatenasalsprayintreatmentofadenoidalhypertrophicsnoringinchildren |
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