Synergistic effect of sertraline and disulfiram against multidrug resistant bacteria as a new alternative to drug repositioning
The repositioning of approved drugs is atopic of interest for the academy and the pharmaceutical industry. The synergistic combination of these drugs can be successful in the treatment of infections caused by resistant bacteria. This study aimed to assess the in vitro synergistic antibacterial activity of sertraline and disulfiram and their interaction with ciprofloxacin and sulfamethoxazole/trimethoprim. We determined the minimum inhibitory concentration, the minimum bactericidal concentration and the fractional inhibitory concentration index. Eighteen bacterial strains were used, being nine American Type Culture Collection reference strains and nine multidrug resistant clinical isolates. Synergy was detected between sertraline and disulfiram against a strain of Staphylococcus aureusATCC 25923 and a clinical isolate of S. aureus. When associated to sulfamethoxazole/trimethoprim and ciprofloxacin, sertraline and disulfiram showed eight synergistic events, which occurred against three different standard strains and two multidrug resistant clinical isolates. When the minimum bactericidal concentration was determined, the bactericidal activity of sertraline was enhanced with disulfiram. Our results suggest that these drugs, widely used to treat depression and chronic alcoholism, have antibacterial potential individually, in association, and combined with antimicrobials, what makes their repositioning a promising therapeutic alternative for the effective treatment of infections caused by multidrug resistant bacteria.
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Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
2020
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oai:scielo:S1984-825020200001005482020-04-02Synergistic effect of sertraline and disulfiram against multidrug resistant bacteria as a new alternative to drug repositioningSerafin,Marissa BolsonBottega,AngelitaFoletto,Vitória SegabinazziRosa,Taciéli Fagundes daRampelotto,Roberta FilipiniCarvalho,Fernanda AguirreHörner,Rosmari Sertraline Disulfiram.Antimicrobial activity Drug synergism Drug repositioning The repositioning of approved drugs is atopic of interest for the academy and the pharmaceutical industry. The synergistic combination of these drugs can be successful in the treatment of infections caused by resistant bacteria. This study aimed to assess the in vitro synergistic antibacterial activity of sertraline and disulfiram and their interaction with ciprofloxacin and sulfamethoxazole/trimethoprim. We determined the minimum inhibitory concentration, the minimum bactericidal concentration and the fractional inhibitory concentration index. Eighteen bacterial strains were used, being nine American Type Culture Collection reference strains and nine multidrug resistant clinical isolates. Synergy was detected between sertraline and disulfiram against a strain of Staphylococcus aureusATCC 25923 and a clinical isolate of S. aureus. When associated to sulfamethoxazole/trimethoprim and ciprofloxacin, sertraline and disulfiram showed eight synergistic events, which occurred against three different standard strains and two multidrug resistant clinical isolates. When the minimum bactericidal concentration was determined, the bactericidal activity of sertraline was enhanced with disulfiram. Our results suggest that these drugs, widely used to treat depression and chronic alcoholism, have antibacterial potential individually, in association, and combined with antimicrobials, what makes their repositioning a promising therapeutic alternative for the effective treatment of infections caused by multidrug resistant bacteria.info:eu-repo/semantics/openAccessUniversidade de São Paulo, Faculdade de Ciências FarmacêuticasBrazilian Journal of Pharmaceutical Sciences v.56 20202020-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100548en10.1590/s2175-97902019000418089 |
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Serafin,Marissa Bolson Bottega,Angelita Foletto,Vitória Segabinazzi Rosa,Taciéli Fagundes da Rampelotto,Roberta Filipini Carvalho,Fernanda Aguirre Hörner,Rosmari |
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Serafin,Marissa Bolson Bottega,Angelita Foletto,Vitória Segabinazzi Rosa,Taciéli Fagundes da Rampelotto,Roberta Filipini Carvalho,Fernanda Aguirre Hörner,Rosmari Synergistic effect of sertraline and disulfiram against multidrug resistant bacteria as a new alternative to drug repositioning |
| author_facet |
Serafin,Marissa Bolson Bottega,Angelita Foletto,Vitória Segabinazzi Rosa,Taciéli Fagundes da Rampelotto,Roberta Filipini Carvalho,Fernanda Aguirre Hörner,Rosmari |
| author_sort |
Serafin,Marissa Bolson |
| title |
Synergistic effect of sertraline and disulfiram against multidrug resistant bacteria as a new alternative to drug repositioning |
| title_short |
Synergistic effect of sertraline and disulfiram against multidrug resistant bacteria as a new alternative to drug repositioning |
| title_full |
Synergistic effect of sertraline and disulfiram against multidrug resistant bacteria as a new alternative to drug repositioning |
| title_fullStr |
Synergistic effect of sertraline and disulfiram against multidrug resistant bacteria as a new alternative to drug repositioning |
| title_full_unstemmed |
Synergistic effect of sertraline and disulfiram against multidrug resistant bacteria as a new alternative to drug repositioning |
| title_sort |
synergistic effect of sertraline and disulfiram against multidrug resistant bacteria as a new alternative to drug repositioning |
| description |
The repositioning of approved drugs is atopic of interest for the academy and the pharmaceutical industry. The synergistic combination of these drugs can be successful in the treatment of infections caused by resistant bacteria. This study aimed to assess the in vitro synergistic antibacterial activity of sertraline and disulfiram and their interaction with ciprofloxacin and sulfamethoxazole/trimethoprim. We determined the minimum inhibitory concentration, the minimum bactericidal concentration and the fractional inhibitory concentration index. Eighteen bacterial strains were used, being nine American Type Culture Collection reference strains and nine multidrug resistant clinical isolates. Synergy was detected between sertraline and disulfiram against a strain of Staphylococcus aureusATCC 25923 and a clinical isolate of S. aureus. When associated to sulfamethoxazole/trimethoprim and ciprofloxacin, sertraline and disulfiram showed eight synergistic events, which occurred against three different standard strains and two multidrug resistant clinical isolates. When the minimum bactericidal concentration was determined, the bactericidal activity of sertraline was enhanced with disulfiram. Our results suggest that these drugs, widely used to treat depression and chronic alcoholism, have antibacterial potential individually, in association, and combined with antimicrobials, what makes their repositioning a promising therapeutic alternative for the effective treatment of infections caused by multidrug resistant bacteria. |
| publisher |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas |
| publishDate |
2020 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100548 |
| work_keys_str_mv |
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