Antioxidant and immunomodulatory activities of Oviductus ranae in mice
Oviductus ranae (OR) is a traditional Chinese medicine, which was first recorded in the Compendium of Materia Medica in the Ming Dynasty. OR contains high amounts of proteins and elicits therapeutic effects on neurasthenia, insomnia, and respiratory symptoms, which are related to oxidative stress and immunodeficiency. This study aimed to obtain the potential of OR for the development of functional food possessing antioxidant and immune-enhancement functions in the same dose. In antioxidant evaluation, OR can significantly decrease malondialdehyde and protein carbonyls (P < 0.05, P < 0.01) and significantly increase total superoxide dismutase and glutathione in a dose-dependent manner (P< 0.05, P < 0.01) against ethanol-induced oxidative stress in mice at 0.1, 1.0, and 3.0 g/kg BW. In immunomodulatory evaluation, OR could significantly enhance the phagocytosis of liver macrophages (P < 0.05, P < 0.01), delayed-type hypersensitivity response (P < 0.05, P < 0.01), hemolytic activity (P < 0.05), antibody-producing cells (P < 0.05), and natural killer cell activity (P < 0.05) in the same dose range described in antioxidant evaluation compared with those in the normal control. OR slightly influenced lymphocyte proliferation, peritoneal macrophage phagocytosis, and immune organ indices in mice. Thus, 3.0 g/kg BW OR showed potential for the development of functional food with antioxidant and immune-enhancement activities.
Main Authors: | Zhang,Yang, Liu,Yang, Yang,Xiudong, Cui,Hao, Xu,Xiaoxiao, Mao,Liping, Zhou,Hongli |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
2018
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400626 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
The antioxidant activity of Chuju polysaccharide and its effects on the viscera of diabetic mice
by: YANG,Jianting, et al.
Published: (2022) -
Immunomodulatory effects of Blaps rynchopetera extract
by: Meng,Di, et al.
Published: (2022) -
Evaluation of immunomodulatory effects of lomefloxacin in mice
by: Majeed,Arfa, et al.
Published: (2020) -
Production optimization and characterization of immunomodulatory peptides obtained from fermented goat placenta
by: Hou,Yinchen, et al.
Published: (2014) -
Immunomodulatory and antitumor activities of the exopolysaccharide produced by potential probiotic Lactobacillus plantarum YW11 in a HT-29 tumor-burdened nude mouse model
by: ZHANG,Min, et al.
Published: (2022)