Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia
Abstract The risk of having microvascular complication is high among Type 2 Diabetes Mellitus (T2DM) patients. However, factors associated with the glycemic control and progression of diabetic retinopathy (DR) in T2DM patients is limited. This study aims to determine association between anti-diabetic agents, glycemic control and progression of diabetic retinopathy in a Malaysian population. A retrospective study conducted in a tertiary teaching hospital in Malaysia, from January 2009 until March 2014. This study enrolled 104 patients aged 40-84 years, with a mean age 63.12 ± 9.18 years. patients had non-proliferative diabetic retinopathy (NPDR, 77%) and 35% had proliferative diabetic retinopathy (PDR). Diabetic macula edema (DME) was present in 20% of NPDR patients, compared with 7% in PDR. Alpha-glucosidase inhibitor (p=0.012), age (p=0.014) and number of antidiabetic agents used (p=0.015) were significantly associated with stages of diabetic retinopathy. Family history of T2DM (p=0.039) was associated with DME. Identifying factors influencing the progression of diabetic retinopathy may aid in optimizing the therapeutic effects of anti-diabetic agents in T2DM patients.
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Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
2018
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oai:scielo:S1984-825020180002006082018-07-20Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in MalaysiaHuri,Hasniza ZamanHuey,Chua ChewMustafa,NorasyikinMohamad,Nor FadhilahKamalden,Tengku Ain Type 2 Diabetes Mellitus Anti-diabetic agents Microvascular complication Diabetic macula edema Diabetic retinopathy Malaysia Abstract The risk of having microvascular complication is high among Type 2 Diabetes Mellitus (T2DM) patients. However, factors associated with the glycemic control and progression of diabetic retinopathy (DR) in T2DM patients is limited. This study aims to determine association between anti-diabetic agents, glycemic control and progression of diabetic retinopathy in a Malaysian population. A retrospective study conducted in a tertiary teaching hospital in Malaysia, from January 2009 until March 2014. This study enrolled 104 patients aged 40-84 years, with a mean age 63.12 ± 9.18 years. patients had non-proliferative diabetic retinopathy (NPDR, 77%) and 35% had proliferative diabetic retinopathy (PDR). Diabetic macula edema (DME) was present in 20% of NPDR patients, compared with 7% in PDR. Alpha-glucosidase inhibitor (p=0.012), age (p=0.014) and number of antidiabetic agents used (p=0.015) were significantly associated with stages of diabetic retinopathy. Family history of T2DM (p=0.039) was associated with DME. Identifying factors influencing the progression of diabetic retinopathy may aid in optimizing the therapeutic effects of anti-diabetic agents in T2DM patients.info:eu-repo/semantics/openAccessUniversidade de São Paulo, Faculdade de Ciências FarmacêuticasBrazilian Journal of Pharmaceutical Sciences v.54 n.2 20182018-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200608en10.1590/s2175-97902018000217484 |
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Huri,Hasniza Zaman Huey,Chua Chew Mustafa,Norasyikin Mohamad,Nor Fadhilah Kamalden,Tengku Ain |
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Huri,Hasniza Zaman Huey,Chua Chew Mustafa,Norasyikin Mohamad,Nor Fadhilah Kamalden,Tengku Ain Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia |
author_facet |
Huri,Hasniza Zaman Huey,Chua Chew Mustafa,Norasyikin Mohamad,Nor Fadhilah Kamalden,Tengku Ain |
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Huri,Hasniza Zaman |
title |
Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia |
title_short |
Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia |
title_full |
Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia |
title_fullStr |
Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia |
title_full_unstemmed |
Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia |
title_sort |
association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in malaysia |
description |
Abstract The risk of having microvascular complication is high among Type 2 Diabetes Mellitus (T2DM) patients. However, factors associated with the glycemic control and progression of diabetic retinopathy (DR) in T2DM patients is limited. This study aims to determine association between anti-diabetic agents, glycemic control and progression of diabetic retinopathy in a Malaysian population. A retrospective study conducted in a tertiary teaching hospital in Malaysia, from January 2009 until March 2014. This study enrolled 104 patients aged 40-84 years, with a mean age 63.12 ± 9.18 years. patients had non-proliferative diabetic retinopathy (NPDR, 77%) and 35% had proliferative diabetic retinopathy (PDR). Diabetic macula edema (DME) was present in 20% of NPDR patients, compared with 7% in PDR. Alpha-glucosidase inhibitor (p=0.012), age (p=0.014) and number of antidiabetic agents used (p=0.015) were significantly associated with stages of diabetic retinopathy. Family history of T2DM (p=0.039) was associated with DME. Identifying factors influencing the progression of diabetic retinopathy may aid in optimizing the therapeutic effects of anti-diabetic agents in T2DM patients. |
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Universidade de São Paulo, Faculdade de Ciências Farmacêuticas |
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2018 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200608 |
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