The in vivo effect of L-arginine on skin elasticity in mice

The in vivo effect of L-arginine on skin elasticity in mice

ABSTRACT The human skin aging process is a complex mechanism that can be induced both by intrinsic and extrinsic factors. Observations include a decrease in the biosynthetic and proliferative capacity of cells, increased expression of matrix metalloproteinases, reduction in collagen type I expression, and the progressive disappearance of elastic tissue in the papillary dermis. L-arginine, the substrate of nitric oxide synthesis, is involved in angiogenesis and cell proliferation, as well as an indirect precursor of collagen synthesis via the proline pathway. The aim of this study was to examine the tensile strength, histology, and immunohistochemistry of female and male mice skin receiving different concentrations of topically applied L-arginine, in order to evaluate the possibility of using L-arginine as an active cosmetic ingredient in antiaging products. The results suggest that the application of L-arginine improves the mechanical resistance of skin from older female mice (20 weeks old) and promotes the formation of a larger amount of collagen and elastic fibers in the skin when applied at a concentration of 15%.

Saved in:
Bibliographic Details
Main Authors: Souza,Ádria do Prado Barros de, Oliveira,Marina Miranda Rocha de, Andrade,Rafael Rocha de, Amorim,Rivadávio Fernandes Batista de, Bocca,Anamélia Lonrezetti, Borin,Maria de Fátima
Format: Digital revista
Language:English
Published: Universidade de São Paulo, Faculdade de Ciências Farmacêuticas 2017
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000300615
Tags: Add Tag
No Tags, Be the first to tag this record!
id oai:scielo:S1984-82502017000300615
record_format ojs
spelling oai:scielo:S1984-825020170003006152017-11-08The in vivo effect of L-arginine on skin elasticity in miceSouza,Ádria do Prado Barros deOliveira,Marina Miranda Rocha deAndrade,Rafael Rocha deAmorim,Rivadávio Fernandes Batista deBocca,Anamélia LonrezettiBorin,Maria de Fátima L-arginine L-arginine/in vivo efficacy Skin aging Elastin Collagen iNOS ABSTRACT The human skin aging process is a complex mechanism that can be induced both by intrinsic and extrinsic factors. Observations include a decrease in the biosynthetic and proliferative capacity of cells, increased expression of matrix metalloproteinases, reduction in collagen type I expression, and the progressive disappearance of elastic tissue in the papillary dermis. L-arginine, the substrate of nitric oxide synthesis, is involved in angiogenesis and cell proliferation, as well as an indirect precursor of collagen synthesis via the proline pathway. The aim of this study was to examine the tensile strength, histology, and immunohistochemistry of female and male mice skin receiving different concentrations of topically applied L-arginine, in order to evaluate the possibility of using L-arginine as an active cosmetic ingredient in antiaging products. The results suggest that the application of L-arginine improves the mechanical resistance of skin from older female mice (20 weeks old) and promotes the formation of a larger amount of collagen and elastic fibers in the skin when applied at a concentration of 15%.info:eu-repo/semantics/openAccessUniversidade de São Paulo, Faculdade de Ciências FarmacêuticasBrazilian Journal of Pharmaceutical Sciences v.53 n.3 20172017-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000300615en10.1590/s2175-97902017000300045
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Souza,Ádria do Prado Barros de
Oliveira,Marina Miranda Rocha de
Andrade,Rafael Rocha de
Amorim,Rivadávio Fernandes Batista de
Bocca,Anamélia Lonrezetti
Borin,Maria de Fátima
spellingShingle Souza,Ádria do Prado Barros de
Oliveira,Marina Miranda Rocha de
Andrade,Rafael Rocha de
Amorim,Rivadávio Fernandes Batista de
Bocca,Anamélia Lonrezetti
Borin,Maria de Fátima
The in vivo effect of L-arginine on skin elasticity in mice
author_facet Souza,Ádria do Prado Barros de
Oliveira,Marina Miranda Rocha de
Andrade,Rafael Rocha de
Amorim,Rivadávio Fernandes Batista de
Bocca,Anamélia Lonrezetti
Borin,Maria de Fátima
author_sort Souza,Ádria do Prado Barros de
title The in vivo effect of L-arginine on skin elasticity in mice
title_short The in vivo effect of L-arginine on skin elasticity in mice
title_full The in vivo effect of L-arginine on skin elasticity in mice
title_fullStr The in vivo effect of L-arginine on skin elasticity in mice
title_full_unstemmed The in vivo effect of L-arginine on skin elasticity in mice
title_sort in vivo effect of l-arginine on skin elasticity in mice
description ABSTRACT The human skin aging process is a complex mechanism that can be induced both by intrinsic and extrinsic factors. Observations include a decrease in the biosynthetic and proliferative capacity of cells, increased expression of matrix metalloproteinases, reduction in collagen type I expression, and the progressive disappearance of elastic tissue in the papillary dermis. L-arginine, the substrate of nitric oxide synthesis, is involved in angiogenesis and cell proliferation, as well as an indirect precursor of collagen synthesis via the proline pathway. The aim of this study was to examine the tensile strength, histology, and immunohistochemistry of female and male mice skin receiving different concentrations of topically applied L-arginine, in order to evaluate the possibility of using L-arginine as an active cosmetic ingredient in antiaging products. The results suggest that the application of L-arginine improves the mechanical resistance of skin from older female mice (20 weeks old) and promotes the formation of a larger amount of collagen and elastic fibers in the skin when applied at a concentration of 15%.
publisher Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
publishDate 2017
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000300615
work_keys_str_mv AT souzaadriadopradobarrosde theinvivoeffectoflarginineonskinelasticityinmice
AT oliveiramarinamirandarochade theinvivoeffectoflarginineonskinelasticityinmice
AT andraderafaelrochade theinvivoeffectoflarginineonskinelasticityinmice
AT amorimrivadaviofernandesbatistade theinvivoeffectoflarginineonskinelasticityinmice
AT boccaanamelialonrezetti theinvivoeffectoflarginineonskinelasticityinmice
AT borinmariadefatima theinvivoeffectoflarginineonskinelasticityinmice
AT souzaadriadopradobarrosde invivoeffectoflarginineonskinelasticityinmice
AT oliveiramarinamirandarochade invivoeffectoflarginineonskinelasticityinmice
AT andraderafaelrochade invivoeffectoflarginineonskinelasticityinmice
AT amorimrivadaviofernandesbatistade invivoeffectoflarginineonskinelasticityinmice
AT boccaanamelialonrezetti invivoeffectoflarginineonskinelasticityinmice
AT borinmariadefatima invivoeffectoflarginineonskinelasticityinmice
_version_ 1756437820810985472

Similar Items