Arginine enzymatic deprivation and diet restriction for cancer treatment

Arginine enzymatic deprivation and diet restriction for cancer treatment

ABSTRACT Recent findings in amino acid metabolism and the differences between normal, healthy cells and neoplastic cells have revealed that targeting single amino acid metabolic enzymes in cancer therapy is a promising strategy for the development of novel therapeutic agents. Arginine is derived from dietary protein intake, body protein breakdown, or endogenous de novo arginine production and several studies have revealed disturbances in its synthesis and metabolism which could enhance or inhibit tumor cell growth. Consequently, there has been an increased interest in the arginine-depleting enzymes and dietary deprivation of arginine and its precursors as a potential antineoplastic therapy. This review outlines the most recent advances in targeting arginine metabolic pathways in cancer therapy and the different chemo- and radio-therapeutic approaches to be co-applied.

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Main Author: Zam,Wissam
Format: Digital revista
Language:English
Published: Universidade de São Paulo, Faculdade de Ciências Farmacêuticas 2017
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000300402
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spelling oai:scielo:S1984-825020170003004022018-02-02Arginine enzymatic deprivation and diet restriction for cancer treatmentZam,Wissam Arginine-depleting enzyme/antineoplastic therapy Dietary deprivation ABSTRACT Recent findings in amino acid metabolism and the differences between normal, healthy cells and neoplastic cells have revealed that targeting single amino acid metabolic enzymes in cancer therapy is a promising strategy for the development of novel therapeutic agents. Arginine is derived from dietary protein intake, body protein breakdown, or endogenous de novo arginine production and several studies have revealed disturbances in its synthesis and metabolism which could enhance or inhibit tumor cell growth. Consequently, there has been an increased interest in the arginine-depleting enzymes and dietary deprivation of arginine and its precursors as a potential antineoplastic therapy. This review outlines the most recent advances in targeting arginine metabolic pathways in cancer therapy and the different chemo- and radio-therapeutic approaches to be co-applied.info:eu-repo/semantics/openAccessUniversidade de São Paulo, Faculdade de Ciências FarmacêuticasBrazilian Journal of Pharmaceutical Sciences v.53 n.3 20172017-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000300402en10.1590/s2175-97902017000300200
institution SCIELO
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country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Zam,Wissam
spellingShingle Zam,Wissam
Arginine enzymatic deprivation and diet restriction for cancer treatment
author_facet Zam,Wissam
author_sort Zam,Wissam
title Arginine enzymatic deprivation and diet restriction for cancer treatment
title_short Arginine enzymatic deprivation and diet restriction for cancer treatment
title_full Arginine enzymatic deprivation and diet restriction for cancer treatment
title_fullStr Arginine enzymatic deprivation and diet restriction for cancer treatment
title_full_unstemmed Arginine enzymatic deprivation and diet restriction for cancer treatment
title_sort arginine enzymatic deprivation and diet restriction for cancer treatment
description ABSTRACT Recent findings in amino acid metabolism and the differences between normal, healthy cells and neoplastic cells have revealed that targeting single amino acid metabolic enzymes in cancer therapy is a promising strategy for the development of novel therapeutic agents. Arginine is derived from dietary protein intake, body protein breakdown, or endogenous de novo arginine production and several studies have revealed disturbances in its synthesis and metabolism which could enhance or inhibit tumor cell growth. Consequently, there has been an increased interest in the arginine-depleting enzymes and dietary deprivation of arginine and its precursors as a potential antineoplastic therapy. This review outlines the most recent advances in targeting arginine metabolic pathways in cancer therapy and the different chemo- and radio-therapeutic approaches to be co-applied.
publisher Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
publishDate 2017
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000300402
work_keys_str_mv AT zamwissam arginineenzymaticdeprivationanddietrestrictionforcancertreatment
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