Quercetin: a flavonoid with the potential to treat asthma
Allergic asthma is a complex inflammatory disorder characterized by airway hyperresponsiveness, eosinophilic inflammation and hypersecretion of mucus. Current therapies include β2-agonists, cysteinyl leukotriene receptor 1 antagonists and corticosteroids. Although these drugs demonstrate beneficial effects, their adverse side effects limit their long-term use. Thus, the development of new compounds with similar therapeutic activities and reduced side effects is both desirable and necessary. Natural compounds are used in some current therapies, as plant-derived metabolites can relieve disease symptoms in the same manner as allopathic medicines. Quercetin is a flavonoid that is naturally found in many fruits and vegetables and has been shown to exert multiple biological effects in experimental models, including the reduction of major symptoms of asthma: bronchial hyperactivity, mucus production and airway inflammation. In this review, we discuss results from the literature that illustrate the potential of quercetin to treat asthma and its exacerbations.
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Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
2012
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oai:scielo:S1984-825020120004000022013-02-14Quercetin: a flavonoid with the potential to treat asthmaFortunato,Laila RigolinAlves,Claudiney de FreitasTeixeira,Maxelle MartinsRogerio,Alexandre Paula Quercetin Flavonoids Asthma Allergic asthma is a complex inflammatory disorder characterized by airway hyperresponsiveness, eosinophilic inflammation and hypersecretion of mucus. Current therapies include β2-agonists, cysteinyl leukotriene receptor 1 antagonists and corticosteroids. Although these drugs demonstrate beneficial effects, their adverse side effects limit their long-term use. Thus, the development of new compounds with similar therapeutic activities and reduced side effects is both desirable and necessary. Natural compounds are used in some current therapies, as plant-derived metabolites can relieve disease symptoms in the same manner as allopathic medicines. Quercetin is a flavonoid that is naturally found in many fruits and vegetables and has been shown to exert multiple biological effects in experimental models, including the reduction of major symptoms of asthma: bronchial hyperactivity, mucus production and airway inflammation. In this review, we discuss results from the literature that illustrate the potential of quercetin to treat asthma and its exacerbations.info:eu-repo/semantics/openAccessUniversidade de São Paulo, Faculdade de Ciências FarmacêuticasBrazilian Journal of Pharmaceutical Sciences v.48 n.4 20122012-12-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000400002en10.1590/S1984-82502012000400002 |
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Fortunato,Laila Rigolin Alves,Claudiney de Freitas Teixeira,Maxelle Martins Rogerio,Alexandre Paula |
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Fortunato,Laila Rigolin Alves,Claudiney de Freitas Teixeira,Maxelle Martins Rogerio,Alexandre Paula Quercetin: a flavonoid with the potential to treat asthma |
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Fortunato,Laila Rigolin Alves,Claudiney de Freitas Teixeira,Maxelle Martins Rogerio,Alexandre Paula |
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Fortunato,Laila Rigolin |
title |
Quercetin: a flavonoid with the potential to treat asthma |
title_short |
Quercetin: a flavonoid with the potential to treat asthma |
title_full |
Quercetin: a flavonoid with the potential to treat asthma |
title_fullStr |
Quercetin: a flavonoid with the potential to treat asthma |
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Quercetin: a flavonoid with the potential to treat asthma |
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quercetin: a flavonoid with the potential to treat asthma |
description |
Allergic asthma is a complex inflammatory disorder characterized by airway hyperresponsiveness, eosinophilic inflammation and hypersecretion of mucus. Current therapies include β2-agonists, cysteinyl leukotriene receptor 1 antagonists and corticosteroids. Although these drugs demonstrate beneficial effects, their adverse side effects limit their long-term use. Thus, the development of new compounds with similar therapeutic activities and reduced side effects is both desirable and necessary. Natural compounds are used in some current therapies, as plant-derived metabolites can relieve disease symptoms in the same manner as allopathic medicines. Quercetin is a flavonoid that is naturally found in many fruits and vegetables and has been shown to exert multiple biological effects in experimental models, including the reduction of major symptoms of asthma: bronchial hyperactivity, mucus production and airway inflammation. In this review, we discuss results from the literature that illustrate the potential of quercetin to treat asthma and its exacerbations. |
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Universidade de São Paulo, Faculdade de Ciências Farmacêuticas |
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2012 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000400002 |
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AT fortunatolailarigolin quercetinaflavonoidwiththepotentialtotreatasthma AT alvesclaudineydefreitas quercetinaflavonoidwiththepotentialtotreatasthma AT teixeiramaxellemartins quercetinaflavonoidwiththepotentialtotreatasthma AT rogerioalexandrepaula quercetinaflavonoidwiththepotentialtotreatasthma |
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