Development and evaluation of a chronotherapeutic drug delivery system of torsemide
The objective of this study was to prepare and evaluate chronotherapeutic drug delivery systems (ChrDDs) of torsemide. Compression coated tablets (CCT) containing torsemide in the core tablet were prepared by the compression coating technique with different grades of polyethylene oxide (PEO WSR 301 & 1105). The optimized formulations were characterised for tabletting parameters and drug polymer interaction by Fourier-Transform Infrared Spectroscopy (FTIR).The hardness of all the CCT using PEO WSR 301 & PEO WSR 1105 were in the range 6-8 kg/cm² & 5.5 to 7 kg/cm² respectively. Their friability values were <0.3%. All the CCT showed a clear lag time but finalized as per the predetermined lag time. As the amount of PEO was increased in the outer layer the drug released was delayed. The drug content of all the CCT was >99%. The FTIR studies showed no interaction throughout the process of development. Formulations of F7 and of P7 were considered optimized formulations since they yielded a predetermined lag time of 6h before burst release. Hence, these formulations can be exploited to achieve chronotherapeutic drug delivery systems of Torsemide for the treatment of hypertension at the time the patient needs it.
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Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
2011
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oai:scielo:S1984-825020110003000172011-10-24Development and evaluation of a chronotherapeutic drug delivery system of torsemideSunil,Songa AmbedkarRao,Nali SreenivasaSrikanth,Meka VenkataUhumwangho,Michael UwumagbeKumar,Kommana Srinivas PhaniMurthy,Kolaplli Venkata Ramana Torsemide Chronotherapeutic drug/delivery systems Polyethylene Oxides Compression coated tablets Predetermined lag time The objective of this study was to prepare and evaluate chronotherapeutic drug delivery systems (ChrDDs) of torsemide. Compression coated tablets (CCT) containing torsemide in the core tablet were prepared by the compression coating technique with different grades of polyethylene oxide (PEO WSR 301 & 1105). The optimized formulations were characterised for tabletting parameters and drug polymer interaction by Fourier-Transform Infrared Spectroscopy (FTIR).The hardness of all the CCT using PEO WSR 301 & PEO WSR 1105 were in the range 6-8 kg/cm² & 5.5 to 7 kg/cm² respectively. Their friability values were <0.3%. All the CCT showed a clear lag time but finalized as per the predetermined lag time. As the amount of PEO was increased in the outer layer the drug released was delayed. The drug content of all the CCT was >99%. The FTIR studies showed no interaction throughout the process of development. Formulations of F7 and of P7 were considered optimized formulations since they yielded a predetermined lag time of 6h before burst release. Hence, these formulations can be exploited to achieve chronotherapeutic drug delivery systems of Torsemide for the treatment of hypertension at the time the patient needs it.info:eu-repo/semantics/openAccessUniversidade de São Paulo, Faculdade de Ciências FarmacêuticasBrazilian Journal of Pharmaceutical Sciences v.47 n.3 20112011-09-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000300017en10.1590/S1984-82502011000300017 |
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Sunil,Songa Ambedkar Rao,Nali Sreenivasa Srikanth,Meka Venkata Uhumwangho,Michael Uwumagbe Kumar,Kommana Srinivas Phani Murthy,Kolaplli Venkata Ramana |
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Sunil,Songa Ambedkar Rao,Nali Sreenivasa Srikanth,Meka Venkata Uhumwangho,Michael Uwumagbe Kumar,Kommana Srinivas Phani Murthy,Kolaplli Venkata Ramana Development and evaluation of a chronotherapeutic drug delivery system of torsemide |
author_facet |
Sunil,Songa Ambedkar Rao,Nali Sreenivasa Srikanth,Meka Venkata Uhumwangho,Michael Uwumagbe Kumar,Kommana Srinivas Phani Murthy,Kolaplli Venkata Ramana |
author_sort |
Sunil,Songa Ambedkar |
title |
Development and evaluation of a chronotherapeutic drug delivery system of torsemide |
title_short |
Development and evaluation of a chronotherapeutic drug delivery system of torsemide |
title_full |
Development and evaluation of a chronotherapeutic drug delivery system of torsemide |
title_fullStr |
Development and evaluation of a chronotherapeutic drug delivery system of torsemide |
title_full_unstemmed |
Development and evaluation of a chronotherapeutic drug delivery system of torsemide |
title_sort |
development and evaluation of a chronotherapeutic drug delivery system of torsemide |
description |
The objective of this study was to prepare and evaluate chronotherapeutic drug delivery systems (ChrDDs) of torsemide. Compression coated tablets (CCT) containing torsemide in the core tablet were prepared by the compression coating technique with different grades of polyethylene oxide (PEO WSR 301 & 1105). The optimized formulations were characterised for tabletting parameters and drug polymer interaction by Fourier-Transform Infrared Spectroscopy (FTIR).The hardness of all the CCT using PEO WSR 301 & PEO WSR 1105 were in the range 6-8 kg/cm² & 5.5 to 7 kg/cm² respectively. Their friability values were <0.3%. All the CCT showed a clear lag time but finalized as per the predetermined lag time. As the amount of PEO was increased in the outer layer the drug released was delayed. The drug content of all the CCT was >99%. The FTIR studies showed no interaction throughout the process of development. Formulations of F7 and of P7 were considered optimized formulations since they yielded a predetermined lag time of 6h before burst release. Hence, these formulations can be exploited to achieve chronotherapeutic drug delivery systems of Torsemide for the treatment of hypertension at the time the patient needs it. |
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Universidade de São Paulo, Faculdade de Ciências Farmacêuticas |
publishDate |
2011 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000300017 |
work_keys_str_mv |
AT sunilsongaambedkar developmentandevaluationofachronotherapeuticdrugdeliverysystemoftorsemide AT raonalisreenivasa developmentandevaluationofachronotherapeuticdrugdeliverysystemoftorsemide AT srikanthmekavenkata developmentandevaluationofachronotherapeuticdrugdeliverysystemoftorsemide AT uhumwanghomichaeluwumagbe developmentandevaluationofachronotherapeuticdrugdeliverysystemoftorsemide AT kumarkommanasrinivasphani developmentandevaluationofachronotherapeuticdrugdeliverysystemoftorsemide AT murthykolapllivenkataramana developmentandevaluationofachronotherapeuticdrugdeliverysystemoftorsemide |
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1756437739480285184 |