Acaricide resistance mechanisms in Rhipicephalus (Boophilus) microplus
Acaricide resistance has become widespread in countries where cattle ticks, Rhipicephalus (Boophilus) microplus, are a problem. Resistance arises through genetic changes in a cattle tick population that causes modifications to the target site, increased metabolism or sequestration of the acaricide, or reduced ability of the acaricide to penetrate through the outer protective layers of the tick’s body. We review the molecular and biochemical mechanisms of acaricide resistance that have been shown to be functional in R. (B.) microplus. From a mechanistic point of view, resistance to pyrethroids has been characterized to a greater degree than any other acaricide class. Although a great deal of research has gone into discovery of the mechanisms that cause organophosphate resistance, very little is defined at the molecular level and organophosphate resistance seems to be maintained through a complex and multifactorial process. The resistance mechanisms for other acaricides are less well understood. The target sites of fipronil and the macrocyclic lactones are known and resistance mechanism studies are in the early stages. The target site of amitraz has not been definitively identified and this is hampering mechanistic studies on this acaricide.
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Colégio Brasileiro de Parasitologia Veterinária
2012
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oai:scielo:S1984-296120120001000022012-04-23Acaricide resistance mechanisms in Rhipicephalus (Boophilus) microplusGuerrero,Felix DavidLovis,LéonoreMartins,João Ricardo Cattle tick resistance mechanisms target site mutation metabolism Acaricide resistance has become widespread in countries where cattle ticks, Rhipicephalus (Boophilus) microplus, are a problem. Resistance arises through genetic changes in a cattle tick population that causes modifications to the target site, increased metabolism or sequestration of the acaricide, or reduced ability of the acaricide to penetrate through the outer protective layers of the tick’s body. We review the molecular and biochemical mechanisms of acaricide resistance that have been shown to be functional in R. (B.) microplus. From a mechanistic point of view, resistance to pyrethroids has been characterized to a greater degree than any other acaricide class. Although a great deal of research has gone into discovery of the mechanisms that cause organophosphate resistance, very little is defined at the molecular level and organophosphate resistance seems to be maintained through a complex and multifactorial process. The resistance mechanisms for other acaricides are less well understood. The target sites of fipronil and the macrocyclic lactones are known and resistance mechanism studies are in the early stages. The target site of amitraz has not been definitively identified and this is hampering mechanistic studies on this acaricide.info:eu-repo/semantics/openAccessColégio Brasileiro de Parasitologia VeterináriaRevista Brasileira de Parasitologia Veterinária v.21 n.1 20122012-03-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612012000100002en10.1590/S1984-29612012000100002 |
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Guerrero,Felix David Lovis,Léonore Martins,João Ricardo |
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Guerrero,Felix David Lovis,Léonore Martins,João Ricardo Acaricide resistance mechanisms in Rhipicephalus (Boophilus) microplus |
author_facet |
Guerrero,Felix David Lovis,Léonore Martins,João Ricardo |
author_sort |
Guerrero,Felix David |
title |
Acaricide resistance mechanisms in Rhipicephalus (Boophilus) microplus |
title_short |
Acaricide resistance mechanisms in Rhipicephalus (Boophilus) microplus |
title_full |
Acaricide resistance mechanisms in Rhipicephalus (Boophilus) microplus |
title_fullStr |
Acaricide resistance mechanisms in Rhipicephalus (Boophilus) microplus |
title_full_unstemmed |
Acaricide resistance mechanisms in Rhipicephalus (Boophilus) microplus |
title_sort |
acaricide resistance mechanisms in rhipicephalus (boophilus) microplus |
description |
Acaricide resistance has become widespread in countries where cattle ticks, Rhipicephalus (Boophilus) microplus, are a problem. Resistance arises through genetic changes in a cattle tick population that causes modifications to the target site, increased metabolism or sequestration of the acaricide, or reduced ability of the acaricide to penetrate through the outer protective layers of the tick’s body. We review the molecular and biochemical mechanisms of acaricide resistance that have been shown to be functional in R. (B.) microplus. From a mechanistic point of view, resistance to pyrethroids has been characterized to a greater degree than any other acaricide class. Although a great deal of research has gone into discovery of the mechanisms that cause organophosphate resistance, very little is defined at the molecular level and organophosphate resistance seems to be maintained through a complex and multifactorial process. The resistance mechanisms for other acaricides are less well understood. The target sites of fipronil and the macrocyclic lactones are known and resistance mechanism studies are in the early stages. The target site of amitraz has not been definitively identified and this is hampering mechanistic studies on this acaricide. |
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Colégio Brasileiro de Parasitologia Veterinária |
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2012 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612012000100002 |
work_keys_str_mv |
AT guerrerofelixdavid acaricideresistancemechanismsinrhipicephalusboophilusmicroplus AT lovisleonore acaricideresistancemechanismsinrhipicephalusboophilusmicroplus AT martinsjoaoricardo acaricideresistancemechanismsinrhipicephalusboophilusmicroplus |
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1756437048992989184 |