Molecular mechanisms of glucose uptake in skeletal muscle at rest and in response to exercise
Abstract Glucose uptake is an important phenomenon for cell homeostasis and for organism health. Under resting conditions, skeletal muscle is dependent on insulin to promote glucose uptake.Insulin, after binding to its membrane receptor, triggers a cascade of intracellular reactions culminating in activation of the glucose transporter 4, GLUT4, among other outcomes.This transporter migrates to the plasma membrane and assists in glucose internalization.However, under special conditions such as physical exercise, alterations in the levels of intracellular molecules such as ATP and calcium actto regulate GLUT4 translocation and glucose uptake in skeletal muscle, regardless of insulinlevels.Regular physical exercise, due to stimulating pathways related to glucose uptake, is an important non-pharmacological intervention for improving glycemic control in obese and diabetic patients. In this mini-review the main mechanisms involved in glucose uptake in skeletal muscle in response to muscle contraction will be investigated.
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Universidade Estadual Paulista
2017
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oai:scielo:S1980-657420170005002022017-04-26Molecular mechanisms of glucose uptake in skeletal muscle at rest and in response to exercisePereira,Rodrigo MartinsMoura,Leandro Pereira deMuñoz,Vitor RosettoSilva,Adelino Sanchez Ramos daGaspar,Rodrigo StellzerRopelle,Eduardo RochetePauli,José Rodrigo exercise skeletal muscle glucose uptake GLUT4 Abstract Glucose uptake is an important phenomenon for cell homeostasis and for organism health. Under resting conditions, skeletal muscle is dependent on insulin to promote glucose uptake.Insulin, after binding to its membrane receptor, triggers a cascade of intracellular reactions culminating in activation of the glucose transporter 4, GLUT4, among other outcomes.This transporter migrates to the plasma membrane and assists in glucose internalization.However, under special conditions such as physical exercise, alterations in the levels of intracellular molecules such as ATP and calcium actto regulate GLUT4 translocation and glucose uptake in skeletal muscle, regardless of insulinlevels.Regular physical exercise, due to stimulating pathways related to glucose uptake, is an important non-pharmacological intervention for improving glycemic control in obese and diabetic patients. In this mini-review the main mechanisms involved in glucose uptake in skeletal muscle in response to muscle contraction will be investigated.info:eu-repo/semantics/openAccessUniversidade Estadual PaulistaMotriz: Revista de Educação Física v.23 n.spe 20172017-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-65742017000500202en10.1590/s1980-6574201700si0004 |
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Pereira,Rodrigo Martins Moura,Leandro Pereira de Muñoz,Vitor Rosetto Silva,Adelino Sanchez Ramos da Gaspar,Rodrigo Stellzer Ropelle,Eduardo Rochete Pauli,José Rodrigo |
| spellingShingle |
Pereira,Rodrigo Martins Moura,Leandro Pereira de Muñoz,Vitor Rosetto Silva,Adelino Sanchez Ramos da Gaspar,Rodrigo Stellzer Ropelle,Eduardo Rochete Pauli,José Rodrigo Molecular mechanisms of glucose uptake in skeletal muscle at rest and in response to exercise |
| author_facet |
Pereira,Rodrigo Martins Moura,Leandro Pereira de Muñoz,Vitor Rosetto Silva,Adelino Sanchez Ramos da Gaspar,Rodrigo Stellzer Ropelle,Eduardo Rochete Pauli,José Rodrigo |
| author_sort |
Pereira,Rodrigo Martins |
| title |
Molecular mechanisms of glucose uptake in skeletal muscle at rest and in response to exercise |
| title_short |
Molecular mechanisms of glucose uptake in skeletal muscle at rest and in response to exercise |
| title_full |
Molecular mechanisms of glucose uptake in skeletal muscle at rest and in response to exercise |
| title_fullStr |
Molecular mechanisms of glucose uptake in skeletal muscle at rest and in response to exercise |
| title_full_unstemmed |
Molecular mechanisms of glucose uptake in skeletal muscle at rest and in response to exercise |
| title_sort |
molecular mechanisms of glucose uptake in skeletal muscle at rest and in response to exercise |
| description |
Abstract Glucose uptake is an important phenomenon for cell homeostasis and for organism health. Under resting conditions, skeletal muscle is dependent on insulin to promote glucose uptake.Insulin, after binding to its membrane receptor, triggers a cascade of intracellular reactions culminating in activation of the glucose transporter 4, GLUT4, among other outcomes.This transporter migrates to the plasma membrane and assists in glucose internalization.However, under special conditions such as physical exercise, alterations in the levels of intracellular molecules such as ATP and calcium actto regulate GLUT4 translocation and glucose uptake in skeletal muscle, regardless of insulinlevels.Regular physical exercise, due to stimulating pathways related to glucose uptake, is an important non-pharmacological intervention for improving glycemic control in obese and diabetic patients. In this mini-review the main mechanisms involved in glucose uptake in skeletal muscle in response to muscle contraction will be investigated. |
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Universidade Estadual Paulista |
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2017 |
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