In vitro Activity of Picroside I in Type 2 Diabetes Based on Oxidative Stress
Abstract The primary factor leading to insulin resistance (IR) and type 2 diabetes mellitus (T2DM) is oxidative stress. Despite its liver-protecting, enzyme-lowering, immune-regulating, and antiviral effects, the impact of picroside I on oxidative stress, glucose utilization, and IR has not been investigated yet. In vitro studies were conducted to evaluate the antioxidant properties of different concentrations of picroside I. The results showed that picroside I effectively suppresses α-glucosidase and α-amylase with IC50 values of 109.75 μg/mL and 160.71 μg/mL in the range of 50-500 μg/mL. Additionally, when IR-HepG2 cells were treated with 80 μg/mL of picroside I, it was found to have little effect on cell viability, increase glucose consumption, decrease the levels of the free radical metabolite malonic dialdehyde, and increase superoxide dismutase activity. These findings indicate that picroside I has the potential to regulate oxidative stress in IR-HepG2 cells, potentially improving IR and exhibiting anti-T2DM activity.
Main Authors: | Liu,Jingya, Zheng,Yinqiu, Dai,Shuang, Li,Li, Wu,Wei, Gou,Rong, Wang,Deyuan, Long,Shiyu, Huang,Meihua, Xu,Zhihong |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Sociedad Química de México A.C.
2023
|
Online Access: | http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1870-249X2023000200130 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Picroside II attenuates ischemia/reperfusion testicular injury by alleviating oxidative stress and apoptosis through reducing nitric oxide synthesis
by: Li,Yanze, et al.
Published: (2019) -
An experimental study of exenatide effects on renal injury in diabetic rats
by: Wang,Xiaodong, et al.
Published: (2019) -
Danzhi Jiangtang capsule regulates the metabolism of blood lipids in hyperlipidemic rats through JAK2/STAT3 pathway
by: YIN,Gang, et al.
Published: (2022) -
A concise synthetic method for 1,3,5-triazinane-2,4-dithiones
by: Li,Zheng, et al.
Published: (2011) -
Cuprous oxide nanoparticles: preparation and evaluation of antifouling activity
by: Shi,Wei-Zhao, et al.
Published: (2019)