Synthesis, Chemical Structure Elucidation and Biological Studies on the Effect of Some Vital Metal Ions on Lisinopril
Complexes of lisinopril as a pharmaceutical ligand with Ca(II), Mg(II), Zn(II), Fe(III) and VO(II), were synthesized and characterized by microanalysis, conductance, infrared and thermogravimetric (TGA/DTG and DTA) measurements. The lisinopril ligand acts as a monodentate feature via one carboxylate oxygen atom. Lisinopril and their complexes have been checked against some kinds of bacteria and fungi which gave a significant effect. The kinetic thermodynamic parameters such as: activation of E*, ΔH*, ΔS* and ΔG* were estimated using Coats and Redfern as well as Horowitz-Metzger equations.
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Sociedad Química de México A.C.
2014
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oai:scielo:S1870-249X20140002000092014-11-12Synthesis, Chemical Structure Elucidation and Biological Studies on the Effect of Some Vital Metal Ions on LisinoprilZaky,M.El-Sayedl,Mohamed Y.El-Megharbel,Samy M.Abo Taleb,SamehRefat,Moamen S. Lisinopril complexes Infrared spectra electronic spectra thermal analysis antimicrobial activity Complexes of lisinopril as a pharmaceutical ligand with Ca(II), Mg(II), Zn(II), Fe(III) and VO(II), were synthesized and characterized by microanalysis, conductance, infrared and thermogravimetric (TGA/DTG and DTA) measurements. The lisinopril ligand acts as a monodentate feature via one carboxylate oxygen atom. Lisinopril and their complexes have been checked against some kinds of bacteria and fungi which gave a significant effect. The kinetic thermodynamic parameters such as: activation of E*, ΔH*, ΔS* and ΔG* were estimated using Coats and Redfern as well as Horowitz-Metzger equations.info:eu-repo/semantics/openAccessSociedad Química de México A.C.Journal of the Mexican Chemical Society v.58 n.2 20142014-06-01info:eu-repo/semantics/articletext/htmlhttp://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1870-249X2014000200009en |
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Zaky,M. El-Sayedl,Mohamed Y. El-Megharbel,Samy M. Abo Taleb,Sameh Refat,Moamen S. |
| spellingShingle |
Zaky,M. El-Sayedl,Mohamed Y. El-Megharbel,Samy M. Abo Taleb,Sameh Refat,Moamen S. Synthesis, Chemical Structure Elucidation and Biological Studies on the Effect of Some Vital Metal Ions on Lisinopril |
| author_facet |
Zaky,M. El-Sayedl,Mohamed Y. El-Megharbel,Samy M. Abo Taleb,Sameh Refat,Moamen S. |
| author_sort |
Zaky,M. |
| title |
Synthesis, Chemical Structure Elucidation and Biological Studies on the Effect of Some Vital Metal Ions on Lisinopril |
| title_short |
Synthesis, Chemical Structure Elucidation and Biological Studies on the Effect of Some Vital Metal Ions on Lisinopril |
| title_full |
Synthesis, Chemical Structure Elucidation and Biological Studies on the Effect of Some Vital Metal Ions on Lisinopril |
| title_fullStr |
Synthesis, Chemical Structure Elucidation and Biological Studies on the Effect of Some Vital Metal Ions on Lisinopril |
| title_full_unstemmed |
Synthesis, Chemical Structure Elucidation and Biological Studies on the Effect of Some Vital Metal Ions on Lisinopril |
| title_sort |
synthesis, chemical structure elucidation and biological studies on the effect of some vital metal ions on lisinopril |
| description |
Complexes of lisinopril as a pharmaceutical ligand with Ca(II), Mg(II), Zn(II), Fe(III) and VO(II), were synthesized and characterized by microanalysis, conductance, infrared and thermogravimetric (TGA/DTG and DTA) measurements. The lisinopril ligand acts as a monodentate feature via one carboxylate oxygen atom. Lisinopril and their complexes have been checked against some kinds of bacteria and fungi which gave a significant effect. The kinetic thermodynamic parameters such as: activation of E*, ΔH*, ΔS* and ΔG* were estimated using Coats and Redfern as well as Horowitz-Metzger equations. |
| publisher |
Sociedad Química de México A.C. |
| publishDate |
2014 |
| url |
http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1870-249X2014000200009 |
| work_keys_str_mv |
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| _version_ |
1756228499838861312 |