Secondary Ligand Effects on the Cytotoxicity of Several Casiopeína's Group II Compounds
The aim of this study is to identify the influence of the ligand aminoacidato on the antiproliferative activity against human tumor cell lines HeLa, HCT-15 and SKL-U through the analysis of a set of Cu(II) coordination compounds with general formula [Cu(4,7-dimethyl-1,10-phenanthroline)(N-O)]NO3where N-O represents several essential aminoacids. Results show that the hydrophobicity of the amino acid ligands increases the cellular uptake of copper (II) in HeLa tumor cell line, however, the increase of copper concentration inside the cell is not enough to produce significant changes in antiproliferative activity in this tumor cell line. Thus, the substituents on diimine ligand apparently play the stronger role to control the activity of these complexes. Also molecular structures of compounds 2 (Cas IIala) and 4 (Cas IInva) are presented.
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Sociedad Química de México A.C.
2012
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oai:scielo:S1870-249X20120001000142013-08-28Secondary Ligand Effects on the Cytotoxicity of Several Casiopeína's Group II CompoundsBravo-Gómez,María ElenaDávila-Manzanilla,SilviaFlood-Garibay,JessicaMuciño-Hernández,Miguel ÁngelMendoza,ÁngelGarcía Ramos,Juan CarlosMoreno-Esparza,RafaelRuiz-Azuara,Lena Copper mixed chelate aminoacids ligand effect inorganic anticancer compounds cytotoxicity intracellular distribution The aim of this study is to identify the influence of the ligand aminoacidato on the antiproliferative activity against human tumor cell lines HeLa, HCT-15 and SKL-U through the analysis of a set of Cu(II) coordination compounds with general formula [Cu(4,7-dimethyl-1,10-phenanthroline)(N-O)]NO3where N-O represents several essential aminoacids. Results show that the hydrophobicity of the amino acid ligands increases the cellular uptake of copper (II) in HeLa tumor cell line, however, the increase of copper concentration inside the cell is not enough to produce significant changes in antiproliferative activity in this tumor cell line. Thus, the substituents on diimine ligand apparently play the stronger role to control the activity of these complexes. Also molecular structures of compounds 2 (Cas IIala) and 4 (Cas IInva) are presented.info:eu-repo/semantics/openAccessSociedad Química de México A.C.Journal of the Mexican Chemical Society v.56 n.1 20122012-03-01info:eu-repo/semantics/articletext/htmlhttp://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1870-249X2012000100014en |
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Bravo-Gómez,María Elena Dávila-Manzanilla,Silvia Flood-Garibay,Jessica Muciño-Hernández,Miguel Ángel Mendoza,Ángel García Ramos,Juan Carlos Moreno-Esparza,Rafael Ruiz-Azuara,Lena |
| spellingShingle |
Bravo-Gómez,María Elena Dávila-Manzanilla,Silvia Flood-Garibay,Jessica Muciño-Hernández,Miguel Ángel Mendoza,Ángel García Ramos,Juan Carlos Moreno-Esparza,Rafael Ruiz-Azuara,Lena Secondary Ligand Effects on the Cytotoxicity of Several Casiopeína's Group II Compounds |
| author_facet |
Bravo-Gómez,María Elena Dávila-Manzanilla,Silvia Flood-Garibay,Jessica Muciño-Hernández,Miguel Ángel Mendoza,Ángel García Ramos,Juan Carlos Moreno-Esparza,Rafael Ruiz-Azuara,Lena |
| author_sort |
Bravo-Gómez,María Elena |
| title |
Secondary Ligand Effects on the Cytotoxicity of Several Casiopeína's Group II Compounds |
| title_short |
Secondary Ligand Effects on the Cytotoxicity of Several Casiopeína's Group II Compounds |
| title_full |
Secondary Ligand Effects on the Cytotoxicity of Several Casiopeína's Group II Compounds |
| title_fullStr |
Secondary Ligand Effects on the Cytotoxicity of Several Casiopeína's Group II Compounds |
| title_full_unstemmed |
Secondary Ligand Effects on the Cytotoxicity of Several Casiopeína's Group II Compounds |
| title_sort |
secondary ligand effects on the cytotoxicity of several casiopeína's group ii compounds |
| description |
The aim of this study is to identify the influence of the ligand aminoacidato on the antiproliferative activity against human tumor cell lines HeLa, HCT-15 and SKL-U through the analysis of a set of Cu(II) coordination compounds with general formula [Cu(4,7-dimethyl-1,10-phenanthroline)(N-O)]NO3where N-O represents several essential aminoacids. Results show that the hydrophobicity of the amino acid ligands increases the cellular uptake of copper (II) in HeLa tumor cell line, however, the increase of copper concentration inside the cell is not enough to produce significant changes in antiproliferative activity in this tumor cell line. Thus, the substituents on diimine ligand apparently play the stronger role to control the activity of these complexes. Also molecular structures of compounds 2 (Cas IIala) and 4 (Cas IInva) are presented. |
| publisher |
Sociedad Química de México A.C. |
| publishDate |
2012 |
| url |
http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1870-249X2012000100014 |
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