Synthesis of Peptides Histamine H2 Receptors in Solid-Phase Assisted by Microwave

Synthesis of Peptides Histamine H2 Receptors in Solid-Phase Assisted by Microwave

The synthesis of histamine H2 receptors peptides was conducted using the methodology of solid phase assisted by microwaves. Microwaves can reduce the reaction times during the coupling and deprotection steps to obtain the desired peptide sequence. The coupling reaction was carried out with a mixture of N, N'-diisopropyl-carbodiimide (DIC) and N,N,N'N'-tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate (HBTU). The purity and yield are improved in peptide synthesis assisted by microwaves. Coupling reactions and deprotection on Rink resin were carried out in 5 min depending on amino acid and the length of the peptide chain.

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Main Authors: Reynoso-Soto,Edgar A., Rivero,Ignacio A.
Format: Digital revista
Language:English
Published: Sociedad Química de México A.C. 2010
Online Access:http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1870-249X2010000300006
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spelling oai:scielo:S1870-249X20100003000062011-02-22Synthesis of Peptides Histamine H2 Receptors in Solid-Phase Assisted by MicrowaveReynoso-Soto,Edgar A.Rivero,Ignacio A. Solid Phase Peptide Microwave The synthesis of histamine H2 receptors peptides was conducted using the methodology of solid phase assisted by microwaves. Microwaves can reduce the reaction times during the coupling and deprotection steps to obtain the desired peptide sequence. The coupling reaction was carried out with a mixture of N, N'-diisopropyl-carbodiimide (DIC) and N,N,N'N'-tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate (HBTU). The purity and yield are improved in peptide synthesis assisted by microwaves. Coupling reactions and deprotection on Rink resin were carried out in 5 min depending on amino acid and the length of the peptide chain.info:eu-repo/semantics/openAccessSociedad Química de México A.C.Journal of the Mexican Chemical Society v.54 n.3 20102010-09-01info:eu-repo/semantics/articletext/htmlhttp://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1870-249X2010000300006en
institution SCIELO
collection OJS
country México
countrycode MX
component Revista
access En linea
databasecode rev-scielo-mx
tag revista
region America del Norte
libraryname SciELO
language English
format Digital
author Reynoso-Soto,Edgar A.
Rivero,Ignacio A.
spellingShingle Reynoso-Soto,Edgar A.
Rivero,Ignacio A.
Synthesis of Peptides Histamine H2 Receptors in Solid-Phase Assisted by Microwave
author_facet Reynoso-Soto,Edgar A.
Rivero,Ignacio A.
author_sort Reynoso-Soto,Edgar A.
title Synthesis of Peptides Histamine H2 Receptors in Solid-Phase Assisted by Microwave
title_short Synthesis of Peptides Histamine H2 Receptors in Solid-Phase Assisted by Microwave
title_full Synthesis of Peptides Histamine H2 Receptors in Solid-Phase Assisted by Microwave
title_fullStr Synthesis of Peptides Histamine H2 Receptors in Solid-Phase Assisted by Microwave
title_full_unstemmed Synthesis of Peptides Histamine H2 Receptors in Solid-Phase Assisted by Microwave
title_sort synthesis of peptides histamine h2 receptors in solid-phase assisted by microwave
description The synthesis of histamine H2 receptors peptides was conducted using the methodology of solid phase assisted by microwaves. Microwaves can reduce the reaction times during the coupling and deprotection steps to obtain the desired peptide sequence. The coupling reaction was carried out with a mixture of N, N'-diisopropyl-carbodiimide (DIC) and N,N,N'N'-tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate (HBTU). The purity and yield are improved in peptide synthesis assisted by microwaves. Coupling reactions and deprotection on Rink resin were carried out in 5 min depending on amino acid and the length of the peptide chain.
publisher Sociedad Química de México A.C.
publishDate 2010
url http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1870-249X2010000300006
work_keys_str_mv AT reynososotoedgara synthesisofpeptideshistamineh2receptorsinsolidphaseassistedbymicrowave
AT riveroignacioa synthesisofpeptideshistamineh2receptorsinsolidphaseassistedbymicrowave
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