Synthesis and Hydrolysis Monitoring of Sasrin-like Resin Bound Imines by Fluorescence Spectroscopy
Merrifield resin was converted to various dialkyl-trihy-droxybenzaldehyde resins and then to different bound imine resins. Fluorescence spectroscopy was used to continuously monitor the intermediates performed on the resins. Using fluorescent label (dansyl chloride) information on the kinetics of the amine cleavage was obtained. This study demonstrated that direct measures of fluorescence intensity on single-resin beads can be an effective method of monitoring solid phase organic reactions.
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| Main Authors: | , , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
Sociedad Química de México A.C.
2006
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| Online Access: | http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1870-249X2006000400006 |
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| Summary: | Merrifield resin was converted to various dialkyl-trihy-droxybenzaldehyde resins and then to different bound imine resins. Fluorescence spectroscopy was used to continuously monitor the intermediates performed on the resins. Using fluorescent label (dansyl chloride) information on the kinetics of the amine cleavage was obtained. This study demonstrated that direct measures of fluorescence intensity on single-resin beads can be an effective method of monitoring solid phase organic reactions. |
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