Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study
OBJECTIVE: In this study, the relationship between osteoporotic vertebral fractures and 9041 Guanine/Adenine and 3673 Guanine/Adenine polymorphisms related to the vitamin K epoxide reductase complex subunit-1 (VKORC1) gene in postmenopausal women with osteoporosis was investigated. METHOD: DNA was isolated from blood samples collected from 150 women with postmenopausal osteoporosis. Genotyping of the two polymorphic regions (9041 Guanine/Adenine and 3673 Guanine/Adenine) in VKORC1 was performed using polymerase chain reaction–restriction fragment length polymorphism analysis. The presence of radiographic fractures among the 150 patients was ascertained by using the Genant method. RESULT: At least one fracture was detected in 98 patients, and no fracture was observed in 52 patients on radiological images. We found no association between the 9041 Guanine/Adenine (p=0.283) and 3673 Guanine/Adenine (p=0.232) polymorphisms of the VKORC1 gene and the development of secondary postosteoporotic fractures in our study. CONCLUSION: There was no relationship between osteoporotic vertebral fracture and VKORC1 gene polymorphism in a postmenopausal Turkish population.
Main Authors: | , , , , , , , , , |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Faculdade de Medicina / USP
2019
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322019000100205 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
oai:scielo:S1807-59322019000100205 |
---|---|
record_format |
ojs |
spelling |
oai:scielo:S1807-593220190001002052019-03-11Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot studyOzgen,MerihCosan,Didem TurgutDoganer,FulyaSoyocak,AhuArmagan,OnurKuzgun,SelenAydogan,Ayse MerveGunes,Hasan VeysiDegirmenci,IrfanMutlu,Fezan Osteoporosis Polymorphism Vitamin K Epoxide Reductase Complex Subunit-1 Gene Vertebral Fracture OBJECTIVE: In this study, the relationship between osteoporotic vertebral fractures and 9041 Guanine/Adenine and 3673 Guanine/Adenine polymorphisms related to the vitamin K epoxide reductase complex subunit-1 (VKORC1) gene in postmenopausal women with osteoporosis was investigated. METHOD: DNA was isolated from blood samples collected from 150 women with postmenopausal osteoporosis. Genotyping of the two polymorphic regions (9041 Guanine/Adenine and 3673 Guanine/Adenine) in VKORC1 was performed using polymerase chain reaction–restriction fragment length polymorphism analysis. The presence of radiographic fractures among the 150 patients was ascertained by using the Genant method. RESULT: At least one fracture was detected in 98 patients, and no fracture was observed in 52 patients on radiological images. We found no association between the 9041 Guanine/Adenine (p=0.283) and 3673 Guanine/Adenine (p=0.232) polymorphisms of the VKORC1 gene and the development of secondary postosteoporotic fractures in our study. CONCLUSION: There was no relationship between osteoporotic vertebral fracture and VKORC1 gene polymorphism in a postmenopausal Turkish population.info:eu-repo/semantics/openAccessFaculdade de Medicina / USPClinics v.74 20192019-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322019000100205en10.6061/clinics/2019/e739 |
institution |
SCIELO |
collection |
OJS |
country |
Brasil |
countrycode |
BR |
component |
Revista |
access |
En linea |
databasecode |
rev-scielo-br |
tag |
revista |
region |
America del Sur |
libraryname |
SciELO |
language |
English |
format |
Digital |
author |
Ozgen,Merih Cosan,Didem Turgut Doganer,Fulya Soyocak,Ahu Armagan,Onur Kuzgun,Selen Aydogan,Ayse Merve Gunes,Hasan Veysi Degirmenci,Irfan Mutlu,Fezan |
spellingShingle |
Ozgen,Merih Cosan,Didem Turgut Doganer,Fulya Soyocak,Ahu Armagan,Onur Kuzgun,Selen Aydogan,Ayse Merve Gunes,Hasan Veysi Degirmenci,Irfan Mutlu,Fezan Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study |
author_facet |
Ozgen,Merih Cosan,Didem Turgut Doganer,Fulya Soyocak,Ahu Armagan,Onur Kuzgun,Selen Aydogan,Ayse Merve Gunes,Hasan Veysi Degirmenci,Irfan Mutlu,Fezan |
author_sort |
Ozgen,Merih |
title |
Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study |
title_short |
Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study |
title_full |
Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study |
title_fullStr |
Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study |
title_full_unstemmed |
Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study |
title_sort |
is there any association between osteoporotic vertebral fracture and vitamin k epoxide reductase complex subunit-1 polymorphism in turkish society? a pilot study |
description |
OBJECTIVE: In this study, the relationship between osteoporotic vertebral fractures and 9041 Guanine/Adenine and 3673 Guanine/Adenine polymorphisms related to the vitamin K epoxide reductase complex subunit-1 (VKORC1) gene in postmenopausal women with osteoporosis was investigated. METHOD: DNA was isolated from blood samples collected from 150 women with postmenopausal osteoporosis. Genotyping of the two polymorphic regions (9041 Guanine/Adenine and 3673 Guanine/Adenine) in VKORC1 was performed using polymerase chain reaction–restriction fragment length polymorphism analysis. The presence of radiographic fractures among the 150 patients was ascertained by using the Genant method. RESULT: At least one fracture was detected in 98 patients, and no fracture was observed in 52 patients on radiological images. We found no association between the 9041 Guanine/Adenine (p=0.283) and 3673 Guanine/Adenine (p=0.232) polymorphisms of the VKORC1 gene and the development of secondary postosteoporotic fractures in our study. CONCLUSION: There was no relationship between osteoporotic vertebral fracture and VKORC1 gene polymorphism in a postmenopausal Turkish population. |
publisher |
Faculdade de Medicina / USP |
publishDate |
2019 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322019000100205 |
work_keys_str_mv |
AT ozgenmerih isthereanyassociationbetweenosteoporoticvertebralfractureandvitaminkepoxidereductasecomplexsubunit1polymorphisminturkishsocietyapilotstudy AT cosandidemturgut isthereanyassociationbetweenosteoporoticvertebralfractureandvitaminkepoxidereductasecomplexsubunit1polymorphisminturkishsocietyapilotstudy AT doganerfulya isthereanyassociationbetweenosteoporoticvertebralfractureandvitaminkepoxidereductasecomplexsubunit1polymorphisminturkishsocietyapilotstudy AT soyocakahu isthereanyassociationbetweenosteoporoticvertebralfractureandvitaminkepoxidereductasecomplexsubunit1polymorphisminturkishsocietyapilotstudy AT armaganonur isthereanyassociationbetweenosteoporoticvertebralfractureandvitaminkepoxidereductasecomplexsubunit1polymorphisminturkishsocietyapilotstudy AT kuzgunselen isthereanyassociationbetweenosteoporoticvertebralfractureandvitaminkepoxidereductasecomplexsubunit1polymorphisminturkishsocietyapilotstudy AT aydoganaysemerve isthereanyassociationbetweenosteoporoticvertebralfractureandvitaminkepoxidereductasecomplexsubunit1polymorphisminturkishsocietyapilotstudy AT guneshasanveysi isthereanyassociationbetweenosteoporoticvertebralfractureandvitaminkepoxidereductasecomplexsubunit1polymorphisminturkishsocietyapilotstudy AT degirmenciirfan isthereanyassociationbetweenosteoporoticvertebralfractureandvitaminkepoxidereductasecomplexsubunit1polymorphisminturkishsocietyapilotstudy AT mutlufezan isthereanyassociationbetweenosteoporoticvertebralfractureandvitaminkepoxidereductasecomplexsubunit1polymorphisminturkishsocietyapilotstudy |
_version_ |
1756432326056738816 |