Prognostic impact of serum albumin levels on the recurrence of stage I non-small cell lung cancer
Objective: Patients with stage I non-small cell lung cancer who have undergone complete surgical resection harbor a 30% risk for tumor recurrence. Thus, the identification of factors that are predictive for tumor recurrence is urgently needed. The aim of this study was to test the prognostic value of serum albumin levels on tumor recurrence in patients with stage I non-small cell lung cancer. Methods: Stage I non-small cell lung cancer patients who underwent complete surgical resection of the primary tumor at Zhejiang Hospital were analyzed in this study. Serum albumin levels were measured before surgery and once again after surgery in 101 histologically diagnosed non-small cell lung cancer patients. Correlations between the pre- and post-operative serum albumin levels and various clinical demographics and recurrence-free survival rates were analyzed. Results: Patients with pre-operative hypoalbuminemia (<3.5 g/dl) had a significantly worse survival rate than patients with normal pre-operative serum albumin levels (≥3.5 g/dl) (p=0.008). Patients with post-operative hypoalbuminemia had a worse survival rate when compared with patients with normal post-operative serum albumin levels (p=0.001). Cox multivariate analysis identified pre-operative hypoalbuminemia, post-operative hypoalbuminemia and tumor size over 3 cm as independent negative prognostic factors for recurrence. Conclusion: Serum albumin levels appear to be a significant independent prognostic factor for tumor recurrence in patients with stage I non-small cell lung cancer who have undergone complete resection. Patient pre-treatment and post-treatment serum albumin levels provide an easy and early means of discrimination between patients with a higher risk for recurrence and patients with a low risk of recurrence.
Main Authors: | Jin,Ying, Zhao,Li, Peng,Fang |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Faculdade de Medicina / USP
2013
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322013000500686 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Identifying activating mutations in the EGFR gene: prognostic and therapeutic implications in non-small cell lung cancer
by: Lopes,Gabriel Lima, et al.
Published: (2015) -
Survival and prognostic factors in patients with Non-Small Cell Lung Cancer treated in private health care
by: Araujo,Luiz Henrique de Lima, et al.
Published: (2014) -
Postoperative transient elevation of serum cancer antigen 125 in non-small cell lung cancer patients
by: Ye,Yiwang
Published: (2021) -
Preoperative serum albumin as a prognostic factor in patients with upper urinary tract urothelial carcinoma
by: Ku,Ja Hyeon, et al.
Published: (2014) -
Pretreatment plasma fibrinogen level as a prognostic biomarker for patients with lung cancer
by: Zhang,Yi, et al.
Published: (2020)