Renal oxygen content is increased in healthy subjects after angiotensin-converting enzyme inhibition
OBJECTIVE: The association between renal hypoxia and the development of renal injury is well established. However, no adequate method currently exists to non-invasively measure functional changes in renal oxygenation in normal and injured patients. METHOD: R2* quantification was performed using renal blood oxygen level-dependent properties. Five healthy normotensive women (50±5.3 years) underwent magnetic resonance imaging in a 1.5T Signa Excite HDx scanner (GE Healthcare, Waukesha, WI). A multiple fast gradient-echo sequence was used to acquire R2*/T2* images (sixteen echoes from 2.1 ms/slice to 49.6 ms/slice in a single breath hold per location). The images were post-processed to generate R2* maps for quantification. Data were recorded before and at 30 minutes after the oral administration of an angiotensin II-converting enzyme inhibitor (captopril, 25 mg). The results were compared using an ANOVA for repeated measurements (mean + standard deviation) followed by the Tukey test. ClinicalTrials.gov: NCT01545479. RESULTS: A significant difference (p<0.001) in renal oxygenation (R2*) was observed in the cortex and medulla before and after captopril administration: right kidney, cortex = 11.08 ± 0.56ms, medulla = 17.21 ± 1.47ms and cortex = 10.30 ± 0.44ms, medulla = 16.06 ± 1.74ms, respectively; and left kidney, cortex= 11.79 ± 1.85ms, medulla = 17.03 ± 0.88ms and cortex = 10.89 ± 0.91ms, medulla = 16.43 ± 1.49ms, respectively. CONCLUSIONS: This result suggests that the technique efficiently measured alterations in renal blood oxygenation after angiotensin II-converting enzyme inhibition and that it may provide a new strategy for identifying the early stages of renal disease and perhaps new therapeutic targets.
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Faculdade de Medicina / USP
2012
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oai:scielo:S1807-593220120007000102012-08-09Renal oxygen content is increased in healthy subjects after angiotensin-converting enzyme inhibitionStein,AnnaGoldmeier,SilviaVoltolini,SarahSetogutti,EnioFeldman,CarlosFigueiredo,EduardoEick,RenatoIrigoyen,MariaRigatto,Katya BOLD Renal Oxygenation Healthy Subjects Captopril Renin-Angiotensin System OBJECTIVE: The association between renal hypoxia and the development of renal injury is well established. However, no adequate method currently exists to non-invasively measure functional changes in renal oxygenation in normal and injured patients. METHOD: R2* quantification was performed using renal blood oxygen level-dependent properties. Five healthy normotensive women (50±5.3 years) underwent magnetic resonance imaging in a 1.5T Signa Excite HDx scanner (GE Healthcare, Waukesha, WI). A multiple fast gradient-echo sequence was used to acquire R2*/T2* images (sixteen echoes from 2.1 ms/slice to 49.6 ms/slice in a single breath hold per location). The images were post-processed to generate R2* maps for quantification. Data were recorded before and at 30 minutes after the oral administration of an angiotensin II-converting enzyme inhibitor (captopril, 25 mg). The results were compared using an ANOVA for repeated measurements (mean + standard deviation) followed by the Tukey test. ClinicalTrials.gov: NCT01545479. RESULTS: A significant difference (p<0.001) in renal oxygenation (R2*) was observed in the cortex and medulla before and after captopril administration: right kidney, cortex = 11.08 ± 0.56ms, medulla = 17.21 ± 1.47ms and cortex = 10.30 ± 0.44ms, medulla = 16.06 ± 1.74ms, respectively; and left kidney, cortex= 11.79 ± 1.85ms, medulla = 17.03 ± 0.88ms and cortex = 10.89 ± 0.91ms, medulla = 16.43 ± 1.49ms, respectively. CONCLUSIONS: This result suggests that the technique efficiently measured alterations in renal blood oxygenation after angiotensin II-converting enzyme inhibition and that it may provide a new strategy for identifying the early stages of renal disease and perhaps new therapeutic targets.info:eu-repo/semantics/openAccessFaculdade de Medicina / USPClinics v.67 n.7 20122012-07-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322012000700010en10.6061/clinics/2012(07)10 |
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Stein,Anna Goldmeier,Silvia Voltolini,Sarah Setogutti,Enio Feldman,Carlos Figueiredo,Eduardo Eick,Renato Irigoyen,Maria Rigatto,Katya |
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Stein,Anna Goldmeier,Silvia Voltolini,Sarah Setogutti,Enio Feldman,Carlos Figueiredo,Eduardo Eick,Renato Irigoyen,Maria Rigatto,Katya Renal oxygen content is increased in healthy subjects after angiotensin-converting enzyme inhibition |
author_facet |
Stein,Anna Goldmeier,Silvia Voltolini,Sarah Setogutti,Enio Feldman,Carlos Figueiredo,Eduardo Eick,Renato Irigoyen,Maria Rigatto,Katya |
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Stein,Anna |
title |
Renal oxygen content is increased in healthy subjects after angiotensin-converting enzyme inhibition |
title_short |
Renal oxygen content is increased in healthy subjects after angiotensin-converting enzyme inhibition |
title_full |
Renal oxygen content is increased in healthy subjects after angiotensin-converting enzyme inhibition |
title_fullStr |
Renal oxygen content is increased in healthy subjects after angiotensin-converting enzyme inhibition |
title_full_unstemmed |
Renal oxygen content is increased in healthy subjects after angiotensin-converting enzyme inhibition |
title_sort |
renal oxygen content is increased in healthy subjects after angiotensin-converting enzyme inhibition |
description |
OBJECTIVE: The association between renal hypoxia and the development of renal injury is well established. However, no adequate method currently exists to non-invasively measure functional changes in renal oxygenation in normal and injured patients. METHOD: R2* quantification was performed using renal blood oxygen level-dependent properties. Five healthy normotensive women (50±5.3 years) underwent magnetic resonance imaging in a 1.5T Signa Excite HDx scanner (GE Healthcare, Waukesha, WI). A multiple fast gradient-echo sequence was used to acquire R2*/T2* images (sixteen echoes from 2.1 ms/slice to 49.6 ms/slice in a single breath hold per location). The images were post-processed to generate R2* maps for quantification. Data were recorded before and at 30 minutes after the oral administration of an angiotensin II-converting enzyme inhibitor (captopril, 25 mg). The results were compared using an ANOVA for repeated measurements (mean + standard deviation) followed by the Tukey test. ClinicalTrials.gov: NCT01545479. RESULTS: A significant difference (p<0.001) in renal oxygenation (R2*) was observed in the cortex and medulla before and after captopril administration: right kidney, cortex = 11.08 ± 0.56ms, medulla = 17.21 ± 1.47ms and cortex = 10.30 ± 0.44ms, medulla = 16.06 ± 1.74ms, respectively; and left kidney, cortex= 11.79 ± 1.85ms, medulla = 17.03 ± 0.88ms and cortex = 10.89 ± 0.91ms, medulla = 16.43 ± 1.49ms, respectively. CONCLUSIONS: This result suggests that the technique efficiently measured alterations in renal blood oxygenation after angiotensin II-converting enzyme inhibition and that it may provide a new strategy for identifying the early stages of renal disease and perhaps new therapeutic targets. |
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Faculdade de Medicina / USP |
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2012 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322012000700010 |
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