Rosuvastatin prevents proteinuria and renal inflammation in nitric oxide-deficient rats
OBJECTIVE: The aim of the present study was to assess the effects of rosuvastatin on renal injury and inflammation in a model of nitric oxide deficiency. METHODS: Male Wistar rats were randomly divided into four groups (n = 10/group) and treated for 28 days with saline (CTRL); 30 mg/kg/day L-NAME (L-name); L-NAME and 20 mg/kg/day rosuvastatin (L-name+ROS-20); or L-NAME and 2 mg/kg/day rosuvastatin (L-name+ROS-2). Systolic blood pressure was measured by plethysmography in the central artery of the tail. The serum total cholesterol, triglycerides, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, creatinine, nitric oxide, interleukin-6, and tumor necrosis factor alpha levels were analyzed. Urine samples were taken to measure the albumin: urinary creatinine ratio. Kidneys were sectioned and stained with hematoxylin/eosin and Masson's trichrome. Immunohistochemical analysis of the renal tissue was performed to detect macrophage infiltration of the glomeruli. RESULTS: The systolic blood pressure was elevated in the L-name but not the L-name+rosuvastatin-20 and L-name+rosuvastatin-2 groups. The L-name group had a significantly reduced nitric oxide level and an increased interleukin-6 and tumor necrosis factor alpha level, albumin: urinary creatinine ratio and number of macrophages in the renal glomeruli. Rosuvastatin increased the nitric oxide level in the L-name+rosuvastatin-2 group and reduced the interleukin-6 and tumor necrosis factor alpha levels, glomerular macrophage number and albumin:urinary creatinine ratio in the L-name+rosuvastatin-20 and L-name+rosuvastatin-2 groups. CONCLUSION: Rosuvastatin treatment reduced glomerular damage due to improvement in the inflammatory pattern independent of the systolic blood pressure and serum lipid level. These effects may lead to improvements in the treatment of kidney disease.
Main Authors: | Girardi,Jose Marcos, Farias,Rogerio Estevan, Ferreira,Ana Paula, Raposo,Nadia Rezende Barbosa |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Faculdade de Medicina / USP
2011
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011000800025 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Administration of BAY 41-2272 prevents bladder dysfunction in nitric-oxide deficient rats
by: D'Ancona,Carlos Arturo Levi, et al.
Published: (2010) -
Nitric oxide and the resolution of inflammation: implications for atherosclerosis
by: Shaw,Catherine A, et al.
Published: (2005) -
NITRIC OXIDE INTERFERES WITH HYPOXIA SIGNALING DURING COLONIC INFLAMMATION
by: CARIA,Cintia Rabelo e Paiva, et al.
Published: (2014) -
Effect of ozone oxidative preconditioning on inflammation and oxidative stress injury in rat model of renal transplantation
by: Wang,Zhishun, et al.
Published: (2018) -
Effect of acute administration of sildenafil to rats with detrusor overactivity induced by chronic deficiency of nitric oxide
by: Reges,Ricardo, et al.
Published: (2013)