Longitudinal study of Cystatin C in healthy term newborns
OBJECTIVE: The purpose of this study was to determine the levels of Cystatin C in healthy term newborns in the first month of life. INTRODUCTION: Cystatin C may be a suitable marker for determining the glomerular filtration rate because it is not affected by maternal renal function. METHODS: Cohort study. Inclusion: term newborns with appropriate weight; mother without renal failure or drugs that could affect fetal glomerular filtration rate. Exclusion: malformations; hypertension or any condition that could affect glomerular filtration rate. Cystatin C (mg/L)and creatinine (rng/dl) were determined in the mother (Mo) and in the newborn at birth (Day-0), 3rd (Day-3), 7th(Day-7) and 28t>h(Day-28) days. Statistics: one way ANOVA and Pearson's correlation tests. Sample size of 20 subjects for a = 5% and a power test = 80% (p<0.05). RESULTS: Data from 21 newborns were obtained (mean + standard deviation): MoCystatin C=1.00 ± 0.20; Day-0 Cystatin C 1.70 ± 0.26; Day-3 Cystatin C = 1.51±0.20; Day-7 Cystatin C = 1.54 ± 0.10; Day-28 Cystatin C= 1.51±0.10. MoCystatin C was smaller than Day-0 Cystatin C (p<0.001), while MoCreatinine was not different from Day-0 Creatinine. Cystatin C only decreased from Day-0 to Day-3 (p = 0.004) but newborns Creatinine decreased along the time. Correlations were obtained between MoCystatin C and MoCreatinine (p = 0.012), as well as Day-3 (p = 0.047) and Day-28 (p = 0.022) Cystatin C and Creatinine values. CONCLUSION: Neonatal Cystatin C values were not affected by MoCystatin C and became stable from the 3rd day of life.
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2011
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oai:scielo:S1807-593220110002000062011-03-31Longitudinal study of Cystatin C in healthy term newbornsNovo,Ana Carolina de Albuquerque Cavalcanti FerreiraSadeck,Lilian dos Santos RodriguesOkay,Thelma SuelyLeone,Clea Rodrigues Serum Cystatin C Glomerular filtration rate Serum creatinine Reference values Infant newborn OBJECTIVE: The purpose of this study was to determine the levels of Cystatin C in healthy term newborns in the first month of life. INTRODUCTION: Cystatin C may be a suitable marker for determining the glomerular filtration rate because it is not affected by maternal renal function. METHODS: Cohort study. Inclusion: term newborns with appropriate weight; mother without renal failure or drugs that could affect fetal glomerular filtration rate. Exclusion: malformations; hypertension or any condition that could affect glomerular filtration rate. Cystatin C (mg/L)and creatinine (rng/dl) were determined in the mother (Mo) and in the newborn at birth (Day-0), 3rd (Day-3), 7th(Day-7) and 28t>h(Day-28) days. Statistics: one way ANOVA and Pearson's correlation tests. Sample size of 20 subjects for a = 5% and a power test = 80% (p<0.05). RESULTS: Data from 21 newborns were obtained (mean + standard deviation): MoCystatin C=1.00 ± 0.20; Day-0 Cystatin C 1.70 ± 0.26; Day-3 Cystatin C = 1.51±0.20; Day-7 Cystatin C = 1.54 ± 0.10; Day-28 Cystatin C= 1.51±0.10. MoCystatin C was smaller than Day-0 Cystatin C (p<0.001), while MoCreatinine was not different from Day-0 Creatinine. Cystatin C only decreased from Day-0 to Day-3 (p = 0.004) but newborns Creatinine decreased along the time. Correlations were obtained between MoCystatin C and MoCreatinine (p = 0.012), as well as Day-3 (p = 0.047) and Day-28 (p = 0.022) Cystatin C and Creatinine values. CONCLUSION: Neonatal Cystatin C values were not affected by MoCystatin C and became stable from the 3rd day of life.info:eu-repo/semantics/openAccessFaculdade de Medicina / USPClinics v.66 n.2 20112011-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011000200006en10.1590/S1807-59322011000200006 |
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Novo,Ana Carolina de Albuquerque Cavalcanti Ferreira Sadeck,Lilian dos Santos Rodrigues Okay,Thelma Suely Leone,Clea Rodrigues |
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Novo,Ana Carolina de Albuquerque Cavalcanti Ferreira Sadeck,Lilian dos Santos Rodrigues Okay,Thelma Suely Leone,Clea Rodrigues Longitudinal study of Cystatin C in healthy term newborns |
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Novo,Ana Carolina de Albuquerque Cavalcanti Ferreira Sadeck,Lilian dos Santos Rodrigues Okay,Thelma Suely Leone,Clea Rodrigues |
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Novo,Ana Carolina de Albuquerque Cavalcanti Ferreira |
title |
Longitudinal study of Cystatin C in healthy term newborns |
title_short |
Longitudinal study of Cystatin C in healthy term newborns |
title_full |
Longitudinal study of Cystatin C in healthy term newborns |
title_fullStr |
Longitudinal study of Cystatin C in healthy term newborns |
title_full_unstemmed |
Longitudinal study of Cystatin C in healthy term newborns |
title_sort |
longitudinal study of cystatin c in healthy term newborns |
description |
OBJECTIVE: The purpose of this study was to determine the levels of Cystatin C in healthy term newborns in the first month of life. INTRODUCTION: Cystatin C may be a suitable marker for determining the glomerular filtration rate because it is not affected by maternal renal function. METHODS: Cohort study. Inclusion: term newborns with appropriate weight; mother without renal failure or drugs that could affect fetal glomerular filtration rate. Exclusion: malformations; hypertension or any condition that could affect glomerular filtration rate. Cystatin C (mg/L)and creatinine (rng/dl) were determined in the mother (Mo) and in the newborn at birth (Day-0), 3rd (Day-3), 7th(Day-7) and 28t>h(Day-28) days. Statistics: one way ANOVA and Pearson's correlation tests. Sample size of 20 subjects for a = 5% and a power test = 80% (p<0.05). RESULTS: Data from 21 newborns were obtained (mean + standard deviation): MoCystatin C=1.00 ± 0.20; Day-0 Cystatin C 1.70 ± 0.26; Day-3 Cystatin C = 1.51±0.20; Day-7 Cystatin C = 1.54 ± 0.10; Day-28 Cystatin C= 1.51±0.10. MoCystatin C was smaller than Day-0 Cystatin C (p<0.001), while MoCreatinine was not different from Day-0 Creatinine. Cystatin C only decreased from Day-0 to Day-3 (p = 0.004) but newborns Creatinine decreased along the time. Correlations were obtained between MoCystatin C and MoCreatinine (p = 0.012), as well as Day-3 (p = 0.047) and Day-28 (p = 0.022) Cystatin C and Creatinine values. CONCLUSION: Neonatal Cystatin C values were not affected by MoCystatin C and became stable from the 3rd day of life. |
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Faculdade de Medicina / USP |
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2011 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011000200006 |
work_keys_str_mv |
AT novoanacarolinadealbuquerquecavalcantiferreira longitudinalstudyofcystatincinhealthytermnewborns AT sadeckliliandossantosrodrigues longitudinalstudyofcystatincinhealthytermnewborns AT okaythelmasuely longitudinalstudyofcystatincinhealthytermnewborns AT leoneclearodrigues longitudinalstudyofcystatincinhealthytermnewborns |
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