Relationship between adipokines, inflammation, and vascular reactivity in lean controls and obese subjects with metabolic syndrome

Relationship between adipokines, inflammation, and vascular reactivity in lean controls and obese subjects with metabolic syndrome

PURPOSE: Metabolic syndrome is an important risk factor for cardiovascular disease. Adipokines interfere with insulin action and endothelial cell function. We investigated the relationship among adipokines, metabolic factors, inflammatory markers, and vascular reactivity in obese subjects with metabolic syndrome and lean controls. METHODS: Cross-sectional study of 19 obese subjects with metabolic syndrome and 8 lean volunteers evaluated as controls. Vascular reactivity was assessed by venous occlusion pletysmography measuring braquial forearm blood flow (FBF) and vascular resistance (VR) responses to intra-arterial infusions of endothelium-dependent (acetylcholine-Ach) and independent (sodium nitroprusside-SNP) vasodilators. Blood samples were obtained to evaluate C reactive protein (CRP), plasminogen activator inhibitor 1 (PAI-1), fibrinogen, adiponectin, resistin, and lipid profile. Patients were classified with regard to insulin resistance through the HOMA-IR index. RESULTS: PAI-1, CRP and fibrinogen were higher and adiponectin was lower in metabolic syndrome subjects compared to controls. Metabolic syndrome subjects had impaired vascular reactivity. Adiponectin and PAI-1 were associated with insulin, HOMA-IR, triglycerides, and HDLc; and resistin with CRP. Adiponectin was associated with VR after Ach in the pooled group and resistin with D FBF after Ach in the metabolic syndrome group. CONCLUSION: Metabolic syndrome subjects exhibited low levels of adiponectin and high levels of CRP, fibrinogen, and PAI-1. Adiponectin and PAI-1 correlated with insulin resistance markers. Adiponectin and resistin correlated with vascular reactivity parameters. An adipocyte-endothelium interaction might be an important mechanism of inflammation and vascular dysfunction.

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Main Authors: Bahia,Luciana, Aguiar,Luiz Guilherme, Villela,Nivaldo, Bottino,Daniel, Godoy-Matos,Amelio F., Geloneze,Bruno, Tambascia,Marcos, Bouskela,Eliete
Format: Digital revista
Language:English
Published: Faculdade de Medicina / USP 2006
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322006000500010
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spelling oai:scielo:S1807-593220060005000102006-10-19Relationship between adipokines, inflammation, and vascular reactivity in lean controls and obese subjects with metabolic syndromeBahia,LucianaAguiar,Luiz GuilhermeVillela,NivaldoBottino,DanielGodoy-Matos,Amelio F.Geloneze,BrunoTambascia,MarcosBouskela,Eliete metabolic syndrome Adipokines Vascular reactivity Inflammation markers Venous occlusion plethysmography PURPOSE: Metabolic syndrome is an important risk factor for cardiovascular disease. Adipokines interfere with insulin action and endothelial cell function. We investigated the relationship among adipokines, metabolic factors, inflammatory markers, and vascular reactivity in obese subjects with metabolic syndrome and lean controls. METHODS: Cross-sectional study of 19 obese subjects with metabolic syndrome and 8 lean volunteers evaluated as controls. Vascular reactivity was assessed by venous occlusion pletysmography measuring braquial forearm blood flow (FBF) and vascular resistance (VR) responses to intra-arterial infusions of endothelium-dependent (acetylcholine-Ach) and independent (sodium nitroprusside-SNP) vasodilators. Blood samples were obtained to evaluate C reactive protein (CRP), plasminogen activator inhibitor 1 (PAI-1), fibrinogen, adiponectin, resistin, and lipid profile. Patients were classified with regard to insulin resistance through the HOMA-IR index. RESULTS: PAI-1, CRP and fibrinogen were higher and adiponectin was lower in metabolic syndrome subjects compared to controls. Metabolic syndrome subjects had impaired vascular reactivity. Adiponectin and PAI-1 were associated with insulin, HOMA-IR, triglycerides, and HDLc; and resistin with CRP. Adiponectin was associated with VR after Ach in the pooled group and resistin with D FBF after Ach in the metabolic syndrome group. CONCLUSION: Metabolic syndrome subjects exhibited low levels of adiponectin and high levels of CRP, fibrinogen, and PAI-1. Adiponectin and PAI-1 correlated with insulin resistance markers. Adiponectin and resistin correlated with vascular reactivity parameters. An adipocyte-endothelium interaction might be an important mechanism of inflammation and vascular dysfunction.info:eu-repo/semantics/openAccessFaculdade de Medicina / USPClinics v.61 n.5 20062006-10-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322006000500010en10.1590/S1807-59322006000500010
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country Brasil
countrycode BR
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access En linea
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region America del Sur
libraryname SciELO
language English
format Digital
author Bahia,Luciana
Aguiar,Luiz Guilherme
Villela,Nivaldo
Bottino,Daniel
Godoy-Matos,Amelio F.
Geloneze,Bruno
Tambascia,Marcos
Bouskela,Eliete
spellingShingle Bahia,Luciana
Aguiar,Luiz Guilherme
Villela,Nivaldo
Bottino,Daniel
Godoy-Matos,Amelio F.
Geloneze,Bruno
Tambascia,Marcos
Bouskela,Eliete
Relationship between adipokines, inflammation, and vascular reactivity in lean controls and obese subjects with metabolic syndrome
author_facet Bahia,Luciana
Aguiar,Luiz Guilherme
Villela,Nivaldo
Bottino,Daniel
Godoy-Matos,Amelio F.
Geloneze,Bruno
Tambascia,Marcos
Bouskela,Eliete
author_sort Bahia,Luciana
title Relationship between adipokines, inflammation, and vascular reactivity in lean controls and obese subjects with metabolic syndrome
title_short Relationship between adipokines, inflammation, and vascular reactivity in lean controls and obese subjects with metabolic syndrome
title_full Relationship between adipokines, inflammation, and vascular reactivity in lean controls and obese subjects with metabolic syndrome
title_fullStr Relationship between adipokines, inflammation, and vascular reactivity in lean controls and obese subjects with metabolic syndrome
title_full_unstemmed Relationship between adipokines, inflammation, and vascular reactivity in lean controls and obese subjects with metabolic syndrome
title_sort relationship between adipokines, inflammation, and vascular reactivity in lean controls and obese subjects with metabolic syndrome
description PURPOSE: Metabolic syndrome is an important risk factor for cardiovascular disease. Adipokines interfere with insulin action and endothelial cell function. We investigated the relationship among adipokines, metabolic factors, inflammatory markers, and vascular reactivity in obese subjects with metabolic syndrome and lean controls. METHODS: Cross-sectional study of 19 obese subjects with metabolic syndrome and 8 lean volunteers evaluated as controls. Vascular reactivity was assessed by venous occlusion pletysmography measuring braquial forearm blood flow (FBF) and vascular resistance (VR) responses to intra-arterial infusions of endothelium-dependent (acetylcholine-Ach) and independent (sodium nitroprusside-SNP) vasodilators. Blood samples were obtained to evaluate C reactive protein (CRP), plasminogen activator inhibitor 1 (PAI-1), fibrinogen, adiponectin, resistin, and lipid profile. Patients were classified with regard to insulin resistance through the HOMA-IR index. RESULTS: PAI-1, CRP and fibrinogen were higher and adiponectin was lower in metabolic syndrome subjects compared to controls. Metabolic syndrome subjects had impaired vascular reactivity. Adiponectin and PAI-1 were associated with insulin, HOMA-IR, triglycerides, and HDLc; and resistin with CRP. Adiponectin was associated with VR after Ach in the pooled group and resistin with D FBF after Ach in the metabolic syndrome group. CONCLUSION: Metabolic syndrome subjects exhibited low levels of adiponectin and high levels of CRP, fibrinogen, and PAI-1. Adiponectin and PAI-1 correlated with insulin resistance markers. Adiponectin and resistin correlated with vascular reactivity parameters. An adipocyte-endothelium interaction might be an important mechanism of inflammation and vascular dysfunction.
publisher Faculdade de Medicina / USP
publishDate 2006
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322006000500010
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